公开(公告)号：US20100204243A1

公开(公告)日：2010-08-12

申请号：US11918080

申请日：2005-04-11

Applicant: Gopal Krishan Khuller ,  Rajesh Pandey ,  Sadhna Sharma ,  Jitendra Nath Verma

Inventor： Gopal Krishan Khuller ,  Rajesh Pandey ,  Sadhna Sharma ,  Jitendra Nath Verma

IPC: A61K31/496 ,  A61P31/06

CPC classification number: A61K9/5153 ,  A61K9/5192

Abstract: A process for the preparation of Poly DL-lactide-co-glycolide nanoparticles having antitubercular drugs encapsulated therein comprising: (i) preparation of an aqueous solution of stable water soluble drugs in DW/NS/PBS (ii) preparation of unstable drugs in DW/NS/PBS (iii) preparation of a polymer and hydrophobic drug solution in an organic solvent, (iv) mixing separately the solutions of steps (i) and (ii) with that of step (iii) and sonicating under cold conditions, (v) adding the above emulsion to aqueous PVA and resonicating under cold conditions, (vi) stirring the emulsion 0nd centrifuging the same (vii) washing the said particles, reconstituting the same and lyophilizing.

Abstract translation: 制备其中包含抗结核药物的聚DL-丙交酯 - 共 - 乙交酯纳米颗粒的方法，其包括：（i）在DW / NS / PBS中制备稳定的水溶性药物的水溶液（ii）在DW中制备不稳定药物 / iii / PBS（iii）在有机溶剂中制备聚合物和疏水性药物溶液，（iv）将步骤（i）和（ii）的溶液与步骤（iii）的溶液分开混合并在冷条件下进行超声处理（ v）将上述乳液加入PVA水溶液中，并在冷条件下重新进行，（vi）搅拌乳液，然后离心分离（vii）洗涤所述颗粒，重构并冻干。

公开(公告)号：US20090030444A1

公开(公告)日：2009-01-29

申请号：US12220388

申请日：2008-07-23

Applicant: Rajesh Pandey ,  Charles R. Shambaugh, JR.

Inventor： Rajesh Pandey ,  Charles R. Shambaugh, JR.

IPC: A61B17/00

CPC classification number: A61B17/32 ,  A61B2017/00243 ,  A61B2017/0046 ,  A61B2017/00469 ,  A61B2017/320056

Abstract: A tunneling device for creating a pathway in subcutaneous tissue of a person's body. The tunneling device includes a member having two ends, where each of the ends defines an insertion surface that facilitates the insertion of the ends into the subcutaneous tissue of the person's body. The tunneling device includes an interchangeable handle connectable to each of the ends. The handle defines a grasping surface and an opening. The opening is configured to receive either of the ends. The grasping surface enables a user to securely hold the handle with one hand to forcibly move the member through the subcutaneous tissue of the person's body to create the pathway in the subcutaneous tissue, and pull a cable of an implant device through the created pathway.

Abstract translation: 用于在人体的皮下组织中产生通路的隧道装置。 隧道装置包括具有两个端部的构件，其中每个端部限定有助于将端部插入人体的皮下组织的插入表面。 隧道装置包括可连接到每个端部的可互换手柄。 手柄限定抓握表面和开口。 开口配置为接收任一端。 抓握表面使得使用者能够用一只手来牢固地握住手柄，以强制地将构件移动通过人体的皮下组织，以在皮下组织中形成通路，并且通过所产生的路径拉动植入装置的电缆。

公开(公告)号：US20070173879A1

公开(公告)日：2007-07-26

申请号：US11337708

申请日：2006-01-23

Applicant: Rajesh Pandey

Inventor： Rajesh Pandey

IPC: A61B17/00

CPC classification number: A61B17/320016 ,  A61B17/00008 ,  A61B17/06109 ,  A61B17/3415 ,  A61B2017/0046 ,  A61B2017/320044 ,  A61B2017/320056

Abstract: A tunneling device for creating a pathway in subcutaneous tissue of a person's body. The tunneling device includes a member having two ends, where each of the ends defines an insertion surface that facilitates the insertion of the ends into the subcutaneous tissue of the person's body. The tunneling device includes an interchangeable handle connectable to each of the ends. The handle defines a grasping surface and an opening. The opening is configured to receive either of the ends. The grasping surface enables a user to securely hold the handle with one hand to forcibly move the member through the subcutaneous tissue of the person's body to create the pathway in the subcutaneous tissue, and pull a cable of an implant device through the created pathway.

Abstract translation: 用于在人体的皮下组织中产生通路的隧道装置。 隧道装置包括具有两个端部的构件，其中每个端部限定有助于将端部插入人体的皮下组织的插入表面。 隧道装置包括可连接到每个端部的可互换手柄。 手柄限定抓握表面和开口。 开口配置为接收任一端。 抓握表面使得使用者能够用一只手来牢固地握住手柄，以强制地将构件移动通过人体的皮下组织，以在皮下组织中产生通路，并通过所产生的通路拉动植入装置的电缆。

公开(公告)号：US10368899B2

公开(公告)日：2019-08-06

申请号：US11332016

申请日：2006-01-13

Applicant: Rajesh Pandey

Inventor： Rajesh Pandey

IPC: A61B17/3205 ,  A61B17/11 ,  A61B17/00

Abstract: A tool for coring a hole in a patient's body. A housing includes a first opening and a second opening and has an axis extending therebetween. A shaft is movably positioned along the axis. A blade assembly is attached to one end of the shaft. The blade assembly comprises a cup having an open end and a closed end and a cutting edge formed around the open end. An interface is attached to the housing, which is shaped and dimensioned to communicate with a connector used to connect a medical device to a the patient's body.

公开(公告)号：US10357274B2

公开(公告)日：2019-07-23

申请号：US12087715

申请日：2007-01-12

Applicant: Rajesh Pandey ,  Charles R. Shambaugh, Jr.

Inventor： Rajesh Pandey ,  Charles R. Shambaugh, Jr.

IPC: A61B17/3205 ,  A61B17/11 ,  A61B17/00

Abstract: A tool for coring a hole in a portion of a patient's body. A cylindrical sheath includes a hollow bore open at both ends. A shaft is axially movable back and forth within the bore. A blade assembly is attached to one end of the shaft. The blade assembly comprises a hollow open cup portion having a closed end and a cutting edge formed around the margin of the open end. An interface is attached to the sheath which is shaped and dimensioned to communicate with a connector used to connect a medical device to a patient's body.

公开(公告)号：US20140024909A1

公开(公告)日：2014-01-23

申请号：US13984437

申请日：2012-02-24

Applicant: Kamal Vij ,  Parag V. Karmarkar ,  Rajesh Pandey ,  Peter Piferi

Inventor： Kamal Vij ,  Parag V. Karmarkar ,  Rajesh Pandey ,  Peter Piferi

IPC: A61M25/01 ,  A61B5/00 ,  A61B18/18 ,  A61M5/00 ,  A61B5/04 ,  A61B18/14

CPC classification number: A61B5/04 ,  A61B5/055 ,  A61B5/062 ,  A61B5/4836 ,  A61B5/6852 ,  A61B18/02 ,  A61B18/06 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/24 ,  A61B2018/00011 ,  A61B2018/1861 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61B2218/002 ,  A61M5/00 ,  A61M25/0127 ,  A61N7/022

Abstract: An MRI-compatible catheter reduces localized heating due to MR scanner-induced currents and includes a shaft having opposite distal and proximal end portions. One or more RF tracking coils are positioned adjacent the distal end portion and each includes a conductive lead that electrically connects the RF tracking coil to an MRI scanner. Each lead includes a series of back and forth segments along its length. The catheter includes one or more sensing electrodes at the shaft distal end portion, each electrically connected to a resistor having high impedance. A sheath surrounds a portion of the elongated shaft and includes at least one RF shield coaxially disposed therewithin. Each RF shield includes elongated inner and outer conductors and an elongated dielectric layer of MRI compatible material sandwiched between the inner and outer conductors. The inner and outer conductors are electrically connected at one end and electrically isolated at an opposite end.

Abstract translation: MRI兼容导管由于MR扫描器感应电流而减少了局部加热，并且包括具有相对的远端和近端部分的轴。 一个或多个RF跟踪线圈定位成与远端部分相邻，并且每个包括将RF跟踪线圈电连接到MRI扫描器的导电引线。 每个引线包括沿其长度的一系列前后段。 导管包括在轴远端部分处的一个或多个感测电极，每个感测电极电连接到具有高阻抗的电阻器。 护套围绕细长轴的一部分并且包括同轴地设置在其中的至少一个RF护罩。 每个RF屏蔽包括细长的内部和外部导体以及夹在内部和外部导体之间的兼容MRI的材料的细长电介质层。 内导体和外导体在一端电连接并在相对端电隔离。