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公开(公告)号：US07919310B2
公开(公告)日：2011-04-05
申请号：US12019428
申请日：2008-01-24
IPC分类号： C12N15/74
CPC分类号： A61K48/005 , C12N2799/022
摘要： The present disclosure demonstrates the successful use of constitutive promoters operatively linked to genes encoding radiosensitizing or radioprotecting factors, administered to cells, tissues, or patients in conjunction with radiation exposure. Also disclosed are pharmacological preparations to be used to increase the levels of radiosensitizing compounds such as TNF-α, or radioprotective compounds such as MnSOD, in specified tissues or tumors of a subject.
摘要翻译： 本公开内容显示了与辐射照射联合施用于细胞，组织或患者的与编码放射增敏剂或放射防护因子的基因有效连接的组成型启动子的成功应用。 还公开了用于在受试者的特定组织或肿瘤中增加放射增敏化合物如TNF-α或放射防护化合物如MnSOD的药理学制剂。
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公开(公告)号：US06605712B1
公开(公告)日：2003-08-12
申请号：US07943812
申请日：1992-09-11
IPC分类号： C12N1511
CPC分类号： A61K41/0023 , A61K38/00 , A61K48/00 , C07K14/52 , C07K14/525 , C07K14/82 , C07K2319/00 , C07K2319/61 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/635 , C12N15/67 , C12N15/85 , C12N2830/001 , C12N2830/002 , C12N2830/008 , C12N2830/85 , G03G15/2025 , G03G2215/2083
摘要： The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
摘要翻译： 本发明提供了包含可编码至少一种多肽的编码区可操作地连接的辐射响应增强子 - 启动子的DNA分子。 编码区可以包含多肽的单个编码序列或编码转录因子的DNA结合，激活或抑制结构域的两个或多个编码序列。 还提供了使用这样的DNA分子调节多肽表达和抑制肿瘤生长的方法。
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公开(公告)号：US06486170B1
公开(公告)日：2002-11-26
申请号：US08248058
申请日：1994-05-24
IPC分类号： A61K3144
CPC分类号： A61K31/40 , A61K31/70 , A61K41/0019 , A61K41/0023 , A61K31/495 , A61K31/41 , A61K31/38 , A61K2300/00
摘要： A signaling pathway is identified that involves the activation of phospholipase A2 and protein kinase C in human cells, which in turn confers x-ray induction of the tumor necrosis factor &agr; (TNF) gene. Inhibition of phospholipase A2 abolishes radiation-mediated arachidonate production, as well as the subsequent activation of protein kinase C and TNF gene expression. These phospholipase A2 inhibitors may be used to ameliorate the adverse-effects of radiotherapy associated with TNF production.
摘要翻译： 识别出涉及人细胞中磷脂酶A2和蛋白激酶C的活化的信号通路，其进而赋予肿瘤坏死因子α（TNF）基因的x射线诱导。 磷脂酶A2的抑制消除辐射介导的花生四烯酸生产，以及随后激活蛋白激酶C和TNF基因表达。 这些磷脂酶A2抑制剂可用于改善与TNF产生相关的放射治疗的不良反应。
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14.发明申请USE OF THE COMBINATION COMPRISING TEMOZOLOMIDE AND TNF-ALPHA FOR TREATING GLIOBLASTOMA 审中-公开包含TEMOZOLOMIDE和TNF-ALPHA联合治疗GLIOBLASTOMA的应用公开(公告)号：US20110091375A1
公开(公告)日：2011-04-21
申请号：US12971953
申请日：2010-12-17
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K31/41 , A61K38/191 , A61K41/0038 , A61K2300/00
摘要： Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Also disclosed are methods of synergistically inhibiting growth of a glioma in a human cancer patient comprising administering temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Pharmaceutical combinations and therapeutic combinations suitable for use in the methods of the invention are also disclosed.
摘要翻译： 公开了协同抑制神经胶质瘤细胞生长的方法，包括使细胞与替莫唑胺和TNFα或与替莫唑胺，TNFα和辐射接触。 还公开了协同抑制人类癌症患者中神经胶质瘤生长的方法，包括给予替莫唑胺和TNFα，或与替莫唑胺，TNFα和辐射。 还公开了适用于本发明方法的药物组合和治疗组合。
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公开(公告)号：US07118862B2
公开(公告)日：2006-10-10
申请号：US10125003
申请日：2002-04-18
IPC分类号： C12Q1/68
CPC分类号： G01N33/5011 , C12Q1/30 , G01N33/5079 , G01N2510/00
摘要： The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such compounds can be useful to modulate the level of apoptosis in a cell. For example, compounds identified according to the methods described herein can be used to treat disorders characterized by excessive apoptosis, e.g., a neurological disorder, or insufficient apoptosis, e.g., cancer.
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公开(公告)号：US06426351B1
公开(公告)日：2002-07-30
申请号：US09637816
申请日：2000-08-11
IPC分类号： A61K3144
CPC分类号： A61K45/06 , A61K31/335
摘要： Chelerythrine is an effective inhibitor of solid tumor growth and is extremely cytotoxic in combination with chemotherapeutic agents that directly damage DNA.
摘要翻译： 白藜芦醇是实体肿瘤生长的有效抑制剂，与直接损伤DNA的化学治疗剂相结合是极细胞毒性的。
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公开(公告)号：US6156736A
公开(公告)日：2000-12-05
申请号：US102997
申请日：1998-06-22
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K41/00 , A61K48/00 , A61K51/00 , A61P9/08 , A61P9/10 , A61P35/00 , C07H21/04 , C07K14/52 , C07K14/525 , C07K14/82 , C12N5/10 , C12N15/63 , C12N15/67 , C12N15/85 , G03G15/20 , A01N43/04
CPC分类号： A61K41/0023 , A61K48/00 , C07K14/52 , C07K14/525 , C07K14/82 , C12N15/63 , C12N15/635 , C12N15/67 , C12N15/85 , G03G15/2025 , A61K38/00 , C07K2319/00 , C07K2319/61 , C07K2319/71 , C07K2319/81 , C12N2830/001 , C12N2830/002 , C12N2830/008 , C12N2830/85 , G03G2215/2083
摘要： The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.
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公开(公告)号：US5612318A
公开(公告)日：1997-03-18
申请号：US212308
申请日：1994-03-14
IPC分类号： A61K41/00 , A61K48/00 , A61K51/00 , A61P9/08 , A61P9/10 , A61P35/00 , C07K14/52 , C07K14/525 , C12N15/09 , C12N15/63 , C12N15/67 , C12N15/85
CPC分类号： A61K41/0023 , C07K14/52 , C07K14/525 , C12N15/63 , C12N15/67 , C12N15/85
摘要： This invention relates to genetic constructs which comprise an enhancer-promoter region which is responsive to radiation, and at least one structural gene whose expression is controlled by the enhancer-promoter. This invention also relates to methods of destroying, altering, or inactivating cells in target tissue by delivering the genetic constructs to the cells of the tissues and inducing expression of the structural gene or genes in the construct by exposing the tissues to ionizing radiation. This invention is useful for treating patients with cancer, clotting disorders, myocardial infarction, and other diseases for which target tissues can be identified and for which gene expression of the construct within the target tissues can alleviate the disease or disorder.
摘要翻译： 本发明涉及包含对辐射有响应的增强子 - 启动子区的遗传构建体和至少一个其表达受增强子启动子控制的结构基因。 本发明还涉及通过将遗传构建体递送至组织的细胞并通过将组织暴露于电离辐射来诱导构建体中的结构基因或基因的表达来破坏，改变或灭活靶组织中的细胞的方法。 本发明可用于治疗癌症患者，凝血障碍，心肌梗塞以及可识别靶组织的其它疾病，靶组织中构建体的基因表达可以缓解疾病或病症。
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公开(公告)号：US09790504B2
公开(公告)日：2017-10-17
申请号：US14893690
申请日：2014-05-21
IPC分类号： C12N15/113 , C07H21/02 , A61K48/00 , A61K31/506 , A61K31/519 , A61K31/713 , A61K45/06 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/506 , A61K31/519 , A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12N2320/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.
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20.发明申请COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS 审中-公开HEDGEHOG抑制剂，辐射和化学治疗剂的联合治疗公开(公告)号：US20110046211A1
公开(公告)日：2011-02-24
申请号：US12913459
申请日：2010-10-27
申请人： Ralph R. Weichselbaum , Zahra Shafaee , Wei Du
发明人： Ralph R. Weichselbaum , Zahra Shafaee , Wei Du
IPC分类号： A61K31/337 , A61P35/00 , C12N5/02
CPC分类号： A61K31/56 , A61K31/337 , A61K31/4355 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.
摘要翻译： 本发明涉及使用刺猬蛋白抑制剂与化疗和/或放射治疗的组合来抑制癌细胞增殖，细胞异常生长和肿瘤细胞生长的治疗组合和方法。 本发明还涉及通过共同施用治疗量的刺猬蛋白抑制剂同时或同时施用化学疗法和/或放射治疗在化疗或放射的哺乳动物癌症患者或辐射和化学疗法的组合中增强抗增殖作用的方法 依次进行化疗和/或放射治疗。
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