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70 条记录 (耗时 0.04 秒)

    Multiple flow path device for oral delivery of discrete units
    15.
    发明授权
    Multiple flow path device for oral delivery of discrete units 失效
    用于口服分离单元的多流路装置

    公开(公告)号：US5910321A

    公开(公告)日：1999-06-08

    申请号：US949753

    申请日：1997-10-14

    申请人： Patrick S.-L. Wong ,  Nathan Roth ,  Vincent J. Ferrari

    发明人： Patrick S.-L. Wong ,  Nathan Roth ,  Vincent J. Ferrari

    IPC分类号： A47G21/18 ,  A61J7/00 ,  A61K9/00 ,  A61K9/24

    CPC分类号： A61J7/0038 ,  A47G21/183 ,  A61K9/0004

    摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.

    摘要翻译： 本发明涉及一种口服活性剂递送系统和用于将活性剂的离散单元递送给患者的方法。 具有第一和第二端的细长管状构件包括第一和第二流动路径。 所述流路中的任一个或两者包含活性剂。 液体被吸入构件的第一端，液体和活性剂被从构件的第二端引出并进入患者的口中。

    Solid formulations of therapeutic proteins for gastrointestinal delivery
    19.
    发明授权
    Solid formulations of therapeutic proteins for gastrointestinal delivery 失效
    用于胃肠道输送的治疗性蛋白质的固体制剂

    公开(公告)号：US5424289A

    公开(公告)日：1995-06-13

    申请号：US99884

    申请日：1993-07-30

    申请人： Heechung Yang ,  Vu A. Nguyen ,  Liang C. Dong ,  Patrick S.-L. Wong

    发明人： Heechung Yang ,  Vu A. Nguyen ,  Liang C. Dong ,  Patrick S.-L. Wong

    IPC分类号： A61K9/16 ,  A61K38/27 ,  A61K38/28 ,  A61K47/12 ,  A61K47/44 ,  A61K38/00

    CPC分类号： A61K38/27 ,  A61K38/28 ,  A61K47/12 ,  A61K47/44 ,  A61K9/1617

    摘要： The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.

    摘要翻译： 本发明涉及治疗性多肽的药物制剂以及水杨酸钠和油的渗透增强混合物，以在口服给药之后通过胃肠道壁，特别是结肠壁提供增强的多肽吸收 ，油的量为总制剂的约10重量％至约30重量％，优选约15重量％至约25重量％，水杨酸钠的量为约70重量％至约90重量％ ，优选约75重量％至约85重量％。 多肽可以是非冻干的。 药物制剂的特征在于固体，其提供用于处理和储存的方便和改进的形式，以及用于制备含有均匀成分混合物的口服剂型（例如丸剂，胶囊和递送容器）。