公开(公告)号：US20160096898A1

公开(公告)日：2016-04-07

申请号：US14864750

申请日：2015-09-24

Applicant: RINAT NEUROSCIENCE CORP. ,  Pfizer Inc.

Inventor： Hong LIANG ,  Yasmina Noubia ABDICHE ,  Javier Fernando CHAPARRO RIGGERS ,  Bruce Charles GOMES ,  Julie Jia Li HAWKINS ,  Jaume PONS ,  Xiayang QIU ,  Pavel STROP ,  Yuli WANG

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

Abstract translation: 本发明提供了与抗蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）结合的拮抗抗体，其抗原结合部分和适体。 还提供了针对肽的抗体，其中抗体结合PCSK9。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及使用这些抗体及其抗原结合部分来降低LDL-胆固醇水平和/或用于治疗和/或预防心血管疾病（包括治疗高胆固醇血症）的治疗方法。

公开(公告)号：US20130273069A1

公开(公告)日：2013-10-17

申请号：US13857063

申请日：2013-04-04

Applicant: Pfizer Inc. ,  Rinat Neuroscience Corp.

Inventor： Hong LIANG ,  Yasmina Noubia ABDICHE ,  Javier Fernando CHAPARRO RIGGERS ,  Bruce Charles GOMES ,  Julie Jia Li HAWKINS ,  Jaume PONS ,  Xiayang QIU ,  Pavel STROP ,  Yuli WANG

IPC: C07K16/40 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.

Abstract translation: 本发明提供了与抗蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）结合的拮抗抗体，其抗原结合部分和适体。 还提供了针对肽的抗体，其中抗体结合PCSK9。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及使用这些抗体及其抗原结合部分来降低LDL-胆固醇水平和/或用于治疗和/或预防心血管疾病（包括治疗高胆固醇血症）的治疗方法。

公开(公告)号：US20130164308A1

公开(公告)日：2013-06-27

申请号：US13719214

申请日：2012-12-18

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Davide Luciano FOLETTI ,  Javier Fernando CHAPARRO RIGGERS ,  Jacob Eli Gunn GLANVILLE ,  Lee Mary Beth SHAUGHNESSY ,  David Louis SHELTON ,  Pavel STROP ,  Wenwu ZHAI

IPC: C07K16/12 ,  A61K45/06 ,  A61K39/40

CPC classification number: C07K16/1271 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2300/00

Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.

Abstract translation: 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明进一步涉及使用这些抗体治疗和/或预防葡萄球菌疾病，包括例如肺炎，菌血症，败血症，眼睛感染和脓肿的治疗方法。

公开(公告)号：US20130122020A1

公开(公告)日：2013-05-16

申请号：US13670730

申请日：2012-11-07

Applicant: Rinat Neuroscience Corp.

Inventor： Shu-Hui LIU ,  Wei-Hsien HO ,  Pavel STROP ,  Magdalena Grazyna DORYWALSKA ,  Arvind RAJPAL ,  David Louis SHELTON ,  Thomas-Toan TRAN

IPC: C07K16/30

CPC classification number: C07K16/28 ,  A61K38/08 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3046 ,  C07K16/3069 ,  C07K16/3076 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

Abstract translation: 本发明提供特异性结合滋养层细胞表面抗原-2（Trop-2）的抗体。 本发明进一步提供了包含此类抗体的抗体缀合物，编码抗体的核酸，以及获得此类抗体的方法。 本发明还涉及这些抗体和Trop-2抗体缀合物用于治疗与Trop-2表达（例如癌症）如结肠，食管，胃，头颈部，肺， 卵巢癌或胰腺癌。

公开(公告)号：US20220332850A1

公开(公告)日：2022-10-20

申请号：US17846933

申请日：2022-06-22

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20190100603A1

公开(公告)日：2019-04-04

申请号：US16157951

申请日：2018-10-11

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglobulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

公开(公告)号：US20170058054A1

公开(公告)日：2017-03-02

申请号：US15351275

申请日：2016-11-14

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Weihsien HO ,  Jaume PONS ,  Arvind RAJPAL ,  Pavel STROP

IPC: C07K16/46 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/283 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/46 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.

Abstract translation: 本发明涉及工程化的异源多聚体蛋白质，更具体地，涉及用于产生和纯化异二聚体蛋白质的方法，例如双特异性抗体和包含免疫球蛋白样铰链序列的其它异二聚体蛋白质。 还提供了用于生产和纯化这些工程异二聚体蛋白的方法及其在诊断和治疗中的应用。