公开(公告)号：US5423739A

公开(公告)日：1995-06-13

申请号：US100071

申请日：1993-07-30

申请人： Joseph B. Phipps ,  Warren W. Howland ,  Allan H. Jevne ,  Carolann Holmblad

发明人： Joseph B. Phipps ,  Warren W. Howland ,  Allan H. Jevne ,  Carolann Holmblad

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/32 ,  A61L15/60 ,  A61N20060101 ,  A61N1/30 ,  C08L33/02 ,  C09J133/26

CPC分类号： C08L33/02 ,  A61K47/32 ,  A61K9/0009 ,  A61K9/7023 ,  A61L15/60 ,  A61N1/044 ,  A61N1/0448 ,  C09J133/26 ,  A61N1/0436 ,  A61N1/0444

摘要： An iontophoretic device having a two-layer active electrode element is disclosed. The active element is composed of overlapping skin contact hydrogel and carrier layers. The carrier layer contains dispersed or dissolved active agent. The active electrode element maintains the active agent in stable form and permits efficient transport of the active agent to the host. Also disclosed is an iontophoretic device having a single layer active electrode element. The single layer is a hydrogel as manufactured or substantially dry and capable of being hydrated before use. The skin contact hydrogel of the two-layer active electrode element preferably.

摘要翻译： 公开了一种具有双层有源电极元件的离子电渗疗法器件。 活性元素由重叠的皮肤接触水凝胶和载体层组成。 载体层含有分散或溶解的活性剂。 活性电极元件将活性剂维持在稳定的形式并且允许有效运输活性剂到主体上。 还公开了具有单层有源电极元件的离子电渗法。 单层是制造或基本上干燥并能够在使用前水合的水凝胶。 优选两层活性电极元件的皮肤接触水凝胶。

公开(公告)号：US20090105632A1

公开(公告)日：2009-04-23

申请号：US12246856

申请日：2008-10-07

申请人： Rama V. Padmanabhan ,  Joseph B. Phipps ,  Janardhanan Anand Subramony ,  Stephen S. Hwang

发明人： Rama V. Padmanabhan ,  Joseph B. Phipps ,  Janardhanan Anand Subramony ,  Stephen S. Hwang

IPC分类号： A61K31/437 ,  A61N1/30 ,  H01S4/00 ,  A61P25/16

CPC分类号： A61N1/30 ,  A61N1/0448 ,  Y10T29/49002

摘要： An electrotransport system for delivery of lisuride or a pharmaceutically acceptable salt thereof. The system has a donor electrode assembly, a counter electrode assembly, and a controller electrically connected to the donor electrode assembly and the counter electrode assembly. The donor electrode assembly has a donor reservoir that contains a lisuride salt. The controller is electrically connected to the donor and counter electrode assemblies and is operatable for controlling current for the electrotransport.

摘要翻译： 一种用于递送黎西汀或其药学上可接受的盐的电转运系统。 该系统具有供体电极组件，对电极组件和电连接到施主电极组件和对电极组件的控制器。 供体电极组件具有含有碘化物盐的供体储存器。 控制器电连接到供体和对电极组件，并且可操作用于控制电输送的电流。

公开(公告)号：US5622530A

公开(公告)日：1997-04-22

申请号：US451119

申请日：1995-05-26

申请人： Joseph B. Phipps

发明人： Joseph B. Phipps

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0448 ,  A61N1/0436 ,  A61N1/0444

摘要： Methods for conducting controlled environment electrotransport are described. The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected control over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for controlled environment electrotransport are also described. In general the apparatus comprises an electrotransport system including an active electrode reservoir having therein both a primary electrode arrangement and a secondary electrode arrangement, with a control arrangement for selected operation of both. The secondary electrode arrangement, being operated different from the primary electrode arrangement, is selected for operation to selectively enhance or otherwise modify ion presence in the active electrode reservoir, to achieve application of the general methods described. The apparatus may include a sensor means therein, for use as feedback to a control system during operation. Methods and systems involving diffusion type delivery are also described.

公开(公告)号：US5525356A

公开(公告)日：1996-06-11

申请号：US776251

申请日：1991-11-14

申请人： Allan H. Jevne ,  Carolann Holmblad ,  Joseph B. Phipps ,  Warren W. Howland

发明人： Allan H. Jevne ,  Carolann Holmblad ,  Joseph B. Phipps ,  Warren W. Howland

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/32 ,  A61L15/60 ,  A61N1/30 ,  C08L33/02 ,  C09J133/26 ,  A61K9/10

CPC分类号： A61K9/7061 ,  A61K47/32 ,  A61K9/0009 ,  A61K9/0014 ,  A61L15/60 ,  A61N1/0428 ,  C08L33/02 ,  C09J133/26 ,  Y10S514/944

摘要： A polymeric, amphoteric hydrogel for use in medical devices and medical devices using the hydrogel. The hydrogel has a first polymer repeating unit having a acid group and a second polymer repeating unit having a base group such that the acid groups and base groups are present in the hydrogel in amounts effective to provide a hydrogel with a strong, amphoteric, nonmobile ionic structure. For example, the hydrogel can be a copolymer of 2-acrylamido-2-methylpropane sulfonic acid and methacrylamido-propyl-trimethylammonium hydroxide. The hydrogel can be an adhesive used to adhere medical devices to the skin of a patient. It can be particularly useful in drug delivery applications such as in iontophoresis devices.

摘要翻译： PCT No.PCT / US91 / 02156 Sec。 371日期：1991年11月14日 102（e）1991年11月14日PCT PCT 1991年3月29日PCT。 出版物WO91 / 15250 PCT 日期1991年10月17日。一种用于医疗装置和使用该水凝胶的医疗装置的聚合物，两性水凝胶。 水凝胶具有具有酸性基团的第一聚合物重复单元和具有碱基的第二聚合物重复单元，使得酸基团和碱基以有效提供具有强，两性，非流动性离子的水凝胶的量存在于水凝胶中 结构体。 例如，水凝胶可以是2-丙烯酰胺基-2-甲基丙磺酸和甲基丙烯酰胺基 - 丙基 - 三甲基氢氧化铵的共聚物。 水凝胶可以是用于将医疗装置粘附到患者皮肤上的粘合剂。 它可以在药物递送应用中特别有用，例如在离子电渗装置中。

公开(公告)号：US5125894A

公开(公告)日：1992-06-30

申请号：US502232

申请日：1990-03-30

申请人： Joseph B. Phipps ,  Lyn C. Moodie

发明人： Joseph B. Phipps ,  Lyn C. Moodie

IPC分类号： A61N1/30

CPC分类号： A61N1/044 ,  A61N1/0448 ,  A61N1/0436 ,  A61N1/0444

摘要： Methods for conducting controlled environment electrotransport are described. The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected control over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for controlled environment electrotransport are also described. In general the apparatus comprises an electrotransport system including an active electrode reservoir having therein both a primary electrode arrangement and a secondary electrode arrangement, with a control arrangement for selected operation of both. The secondary electrode arrangement, being operated different from the primary electrode arrangement, is selected for operation to selectively enhance or otherwise modify ion presence in the active electrode reservoir, to achieve application of the general methods described. The apparatus may include a sensor means therein, for use as feedback to a control system during operation. Methods and systems involving diffusion type delivery are also described.

摘要翻译： 描述了控制环境电传输的方法。 该方法通常涉及在电运输系统中控制活性电极池的离子环境。 该控制可以用于例如维持恒定的外来离子存在，例如pH。 也可以以优选的方式施用，以便在存在外来离子的情况下保持对目标物种的输送速率的选择性控制。 还描述了可用于提供受控环境电传输的设备。 通常，该装置包括电传输系统，其包括其中具有主电极布置和次电极布置的有源电极储存器，具有用于两者的选择操作的控制装置。 选择与主电极装置不同的次级电极装置用于操作以选择性地增强或以其它方式改变活性电极储存器中的离子存在，以实现所述的一般方法的应用。 该装置可以包括其中的传感器装置，用于在操作期间用作对控制系统的反馈。 还描述了涉及扩散型输送的方法和系统。

公开(公告)号：US5057072A

公开(公告)日：1991-10-15

申请号：US616724

申请日：1990-11-21

申请人： Joseph B. Phipps

发明人： Joseph B. Phipps

IPC分类号： A61N1/30

CPC分类号： A61N1/0436

摘要： An improved iontophoresis electrode employing a current distributing member and a drug reservoir containing an ionic drug. The current distribution member is separated from the drug reservoir by means of a membrane or material selective for ions having a charge opposite to the charge of the ionic drug. The selective material is applied directly to the current distributing member.

摘要翻译： 使用电流分布构件的改进的离子电渗电极和含有离子药物的药物储存器。 电流分布构件通过对具有与离子药物的电荷相反的电荷的离子选择性的膜或材料与药物储存器分离。 选择性材料直接施加到电流分配构件。

公开(公告)号：US20100076368A1

公开(公告)日：2010-03-25

申请号：US12627230

申请日：2009-11-30

申请人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P. Haak ,  Joseph B. Phipps

发明人： Larry A. McNichols ,  John D. Badzinski ,  William N. Reining ,  Gary A. Lattin ,  Ronald P. Haak ,  Joseph B. Phipps

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.

摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。

公开(公告)号：US07660627B2

公开(公告)日：2010-02-09

申请号：US11334001

申请日：2006-01-18

申请人： Larry A. McNichols ,  Joseph B. Phipps ,  Gary A. Lattin ,  John D. Badzinski ,  Wiliam N. Reining ,  Ronald P. Haak

发明人： Larry A. McNichols ,  Joseph B. Phipps ,  Gary A. Lattin ,  John D. Badzinski ,  Wiliam N. Reining ,  Ronald P. Haak

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325

摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.

摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，包含该药剂的至少一个电极，用于产生用于递送药剂的电流（IL）的电源，电流产生和控制装置和 一种永久不可逆地禁用电流的禁用手段。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。

公开(公告)号：US6004309A

公开(公告)日：1999-12-21

申请号：US843561

申请日：1997-04-18

申请人： Joseph B. Phipps

发明人： Joseph B. Phipps

IPC分类号： A61N1/30 ,  A61M31/00

CPC分类号： A61N1/044 ,  A61N1/0448 ,  A61N1/0436 ,  A61N1/0444

摘要： Methods for conducting operation of an electrode arrangement are described. The methods generally concern use of an electrode reservoir containing both a first electrode and a secondary electrode. A system for practicing the methods is also provided.

摘要翻译： 描述了用于进行电极布置操作的方法。 该方法通常涉及使用包含第一电极和次级电极的电极储存器。 还提供了一种实践方法的系统。

公开(公告)号：US5573503A

公开(公告)日：1996-11-12

申请号：US55394

申请日：1993-04-30

申请人： Darrel F. Untereker ,  Joseph B. Phipps ,  Gary A. Lattin

发明人： Darrel F. Untereker ,  Joseph B. Phipps ,  Gary A. Lattin

IPC分类号： A61N1/30

CPC分类号： A61N1/30 ,  A61N1/0448 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0444

摘要： Improved methods of ionophoretic drug delivery are described. By the intentional selection of drug(s) with specific characteristics, of ionotophoresis device, components or both permits the efficiency of drug delivery is increased.