公开(公告)号：US06837280B2

公开(公告)日：2005-01-04

申请号：US10486914

申请日：2003-06-27

Applicant: Pierantonio Ragazzini ,  Elvio Gasperini ,  Roberto Trebbi ,  Enrico Zerbinati ,  Riccardo Rivalta ,  Nicola Gandolfi ,  Giorgio Tarozzi

Inventor： Pierantonio Ragazzini ,  Elvio Gasperini ,  Roberto Trebbi ,  Enrico Zerbinati ,  Riccardo Rivalta ,  Nicola Gandolfi ,  Giorgio Tarozzi

IPC: B65B3/12 ,  A61J3/07 ,  B65B1/38 ,  B65B3/28 ,  B65B3/32 ,  B65B1/04

CPC classification number: A61J3/074 ,  A61J2200/74 ,  B65B1/38 ,  B65B3/32

Abstract: A unit (6) for checking the dosing of pharmaceutical material (M) in a capsule filling machine (1) for the production of capsules (CF) of the type with a capsule lid (C) and a capsule body (F), the machine (1) comprising a fixed structure (15) fitted with a rotary drum (2) for supporting a plurality of capsules (CF) on its edge, opening each capsule (CF) by separating the capsule lid (C) from the capsule body (F), filling the capsule body (F) with a dose of material (M), then closing the capsule body (F) again with the relative capsule lid (C); the rotary drum (2) having a tank (5) containing the pharmaceutical material (M) and supporting a plurality of doser elements (3), each comprising at least one piston (8) sliding inside a hollow cylinder (4) to pick up and compress a dose (DS) of material (M) from the tank (5) and discharge it into a capsule body (F) of a capsule (CF). The unit (6) comprises sensor means (9) attached to each piston (8) for detecting a piston (8) thrust value (V; V1) on the dose (DS) and transmitter means (10) connected to the sensor means (9) for transmitting the value (V; V1) to a receiver element (11; 41) by the telemetric transmission of a relative signal (S; S1), said receiver element (11; 41) being fixed on the machine (1) in at least one zone (P1; P2) of the fixed structure (15). Power supply means (12, 14a) are also provided for cyclically activating the sensor means (9) and the transmitter means (10) during drum (2) rotation.

Abstract translation: 一种用于在用于制造具有胶囊盖（C）和胶囊主体（F）的胶囊（CF）的胶囊填充机（1）中用于检查药物材料（M）的剂量的单元（6）， 机器（1）包括装配有用于在其边缘上支撑多个胶囊（CF）的旋转鼓（2）的固定结构（15），通过将胶囊盖（C）与胶囊主体 （F），用一定量的材料（M）填充胶囊主体（F），然后用相对的胶囊盖（C）再次封闭胶囊主体（F）; 所述旋转鼓（2）具有容纳所述药物材料（M）并且支撑多个加药器元件（3）的罐（5），每个所述加药器元件（3）包括在中空圆柱体（4）内滑动的至少一个活塞（8） 并且从所述罐（5）压缩材料（M）的剂量（DS）并将其排出到胶囊（CF）的胶囊体（F）中。 单元（6）包括附接到每个活塞（8）的传感器装置（9），用于检测剂量（DS）上的活塞（8）推力值（V; V1）和连接到传感器装置的传送装置（10） 9），用于通过相对信号（S; S1）的遥测传输将值（V; V1）发送到接收器元件（11; 41），所述接收器元件（11; 41）固定在机器（1）上， 在所述固定结构（15）的至少一个区域（P1; P2）中。 还提供电源装置（12,14a），用于在鼓（2）旋转期间循环地启动传感器装置（9）和发射器装置（10）。

公开(公告)号：US07677016B2

公开(公告)日：2010-03-16

申请号：US10568506

申请日：2005-05-09

Applicant: Roberto Trebbi

Inventor： Roberto Trebbi

IPC: B65B47/00

CPC classification number: A61J3/074 ,  B65B1/366 ,  B65B1/48

Abstract: A capsule filling machine (100) for the production of hard gelatin capsules (C) of the type with lid (3) and body (2) containing a quantity (1) of pharmaceutical material comprises a rotary turret or carousel (15) which defines at least one capsule (C) handling line (L) and on which the following are positioned, one after the other: at least one station (6) for feeding empty capsules (C); at least one opening station (20) where the capsule bodies (2) are separated from the lids (3) to form two separate rows of capsule bodies (2) and lids (3); at least one station (7) for feeding and dosing the quantities (1) of pharmaceutical material to be filled into the capsule bodies (2); and at least one station (8) for closing the capsules (C) by placing a lid (3) over each respective body (2); the machine (100) also comprises means (9) for detecting and volumetrically checking the quantity (1) of pharmaceutical material filled into each capsule body (2), the detecting and checking means (9) comprise transducer means (5) for measuring the volume of said quantities (1) before they are filled into the capsule bodies (2).

Abstract translation: 用于生产具有盖（3）和包含数量（1）药物材料的盖子（3）和主体（2）的类型的硬明胶胶囊（C）的胶囊填充机（100）包括旋转转盘或转盘（15），其定义 至少一个胶囊（C）处理线（L），并且其上定位有下列物品：至少一个用于供给空胶囊（C）的工位（6）; 至少一个开口站（20），其中所述胶囊主体（2）与所述盖（3）分离以形成两个独立的胶囊体（2）和盖（3）排; 至少一个站（7），用于将要填充的药物材料的数量（1）进料和给药到胶囊体（2）中; 以及至少一个用于通过在每个相应的主体（2）上放置盖子（3）来关闭胶囊（C）的工位（8）。 机器（100）还包括用于检测和体积检查填充到每个胶囊主体（2）中的药物材料的量（1）的装置（9），检测和检查装置（9）包括用于测量 所述量（1）的体积在它们被装入胶囊体（2）之前。

公开(公告)号：US07012242B2

公开(公告)日：2006-03-14

申请号：US10487228

申请日：2003-06-27

Applicant: Giorgio Tarozzi ,  Riccardo Rivalta ,  Roberto Trebbi ,  Pierantonio Ragazzini

Inventor： Giorgio Tarozzi ,  Riccardo Rivalta ,  Roberto Trebbi ,  Pierantonio Ragazzini

IPC: B07C5/344 ,  G01V8/00

CPC classification number: G01N21/9508 ,  A61J3/074 ,  B07C5/3404 ,  B07C5/342 ,  B07C5/365

Abstract: In a method for optoelectronically inspecting pharmaceutical capsules (2) in a capsule filling machine (1), the pharmaceutical capsules (2) are fed in single file from a station (3) where the capsules (2) are made to a capsule (2) outfeed portion (8) of the machine (1) along a defined feed path (P) passing through an inspection station (13). In the inspection station (13), each pharmaceutical capsule (2) passes through an electromagnetic field created by coherent, polarised light radiation.

Abstract translation: 在胶囊填充机（1）中用于光电检测药物胶囊（2）的方法中，药物胶囊（2）以单个文件从胶囊（2）制成的胶囊（2） ）机器（1）的输出部分（8）沿着通过检查站（13）的限定的进给路径（P）。 在检查站（13）中，每个药物胶囊（2）通过由相干偏振光辐射产生的电磁场。

公开(公告)号：US20050007588A1

公开(公告)日：2005-01-13

申请号：US10487228

申请日：2003-06-27

Applicant: Giorgio Tarozzi ,  Riccardo Rivalta ,  Roberto Trebbi ,  Pierantonio Ragazzini

Inventor： Giorgio Tarozzi ,  Riccardo Rivalta ,  Roberto Trebbi ,  Pierantonio Ragazzini

IPC: G01F13/00 ,  A61J3/07 ,  B07C5/34 ,  B07C5/342 ,  B65B57/10 ,  G01N21/95 ,  G01N21/00

CPC classification number: G01N21/9508 ,  A61J3/074 ,  B07C5/3404 ,  B07C5/342 ,  B07C5/365

Abstract: In a method for optoelectronically inspecting pharmaceutical capsules (2) in a capsule filling machine (1), the pharmaceutical capsules (2) are fed in single file from a station (3) where the capsules (2) are made to a capsule (2) outfeed portion (8) of the machine (1) along a defined feed path (P) passing through an inspection station (13). In the inspection station (13), each pharmaceutical capsule (2) passes through an electromagnetic field created by coherent, polarised light radiation.

Abstract translation: 在胶囊填充机（1）中用于光电检测药物胶囊（2）的方法中，药物胶囊（2）以单个文件从胶囊（2）制成的胶囊（2） ）机器（1）的输出部分（8）沿着通过检查站（13）的限定的进给路径（P）。 在检查站（13）中，每个药物胶囊（2）通过由相干偏振光辐射产生的电磁场。

公开(公告)号：US09157784B2

公开(公告)日：2015-10-13

申请号：US13133699

申请日：2009-12-16

Applicant: Roberto Trebbi ,  Salvatore Fabrizio Consoli

Inventor： Roberto Trebbi ,  Salvatore Fabrizio Consoli

IPC: B65B1/04 ,  B65B31/00 ,  G01G17/00 ,  A61J3/07 ,  G01G7/06 ,  G01G9/00

CPC classification number: G01G17/00 ,  A61J3/074 ,  A61J2200/74 ,  G01G7/06 ,  G01G9/005

Abstract: A machine for dosing a plurality of products in capsules, or similar containers, includes a plurality of dosing units for filling the capsules with respective products and a turret arrangement that rotates intermittently and is arranged for housing and moving the capsules in sequence through the dosing units. The machine further includes a plurality of checking units, each of which is located downstream of a respective dosing unit for measuring a quantity of product dosed in the capsules by the respective dosing units.

Abstract translation: 用于对胶囊或类似容器中的多个产品进行计量的机器包括多个用于用相应产品填充胶囊的计量单元和一个间歇旋转的转台装置，并且被布置成依次通过配量单元容纳和移动胶囊 。 机器还包括多个检查单元，每个检查单元位于相应的给料单元的下游，用于测量通过相应的给料单元在胶囊中计量的产品的量。

公开(公告)号：US20080236106A1

公开(公告)日：2008-10-02

申请号：US10586874

申请日：2005-02-23

Applicant: Roberto Trebbi ,  Caterina Funaro

Inventor： Roberto Trebbi ,  Caterina Funaro

IPC: A61J3/07

CPC classification number: A61J3/072 ,  A61J3/074

Abstract: A capsule filling machine (4) for the production of hard gelatin capsules (C) of the type with lid (2) and body (1) containing pharmaceutical material, the machine (4) being of the type comprising a station (5) for feeding the capsule bodies (1) and lids (2); a dosing station (6) for filling a dose of the material into each capsule body (1); and a station (7) for closing the capsules (C) by placing each lid (2) over the respective body (1) so that their respective annular ends (2a, 1a) overlap. Between the dosing station (6) and the closing station (7) there is at least one intermediate operating station (8) for applying a sealing substance to the capsule lid and bodies in the vicinity of their ends (1a, 2a).

Abstract translation: 一种用于生产具有盖（2）和含有药物材料的主体（1）类型的硬明胶胶囊（C）的胶囊填充机（4），所述机器（4）是包括用于 喂食胶囊体（1）和盖子（2）; 用于将一定剂量的材料填充到每个胶囊主体（1）中的计量站（6）; 以及用于通过将每个盖子（2）放置在相应的主体（1）上以使它们各自的环形端部（2a，1a）重叠的方式来封闭胶囊（C）的工位（7）。 在配量站（6）和关闭站（7）之间有至少一个中间操作站（8），用于将密封物质施加到胶囊盖和其末端（1a，2a）附近的主体。

公开(公告)号：US20080145287A1

公开(公告)日：2008-06-19

申请号：US11795717

申请日：2006-02-02

Applicant: Roberto Trebbi ,  Elvio Gasperini ,  Vittoriano Marcheschi ,  Patrizia Nanni ,  Laura Marcheschi ,  Chiara Marcheschi

Inventor： Roberto Trebbi ,  Elvio Gasperini ,  Vittoriano Marcheschi ,  Patrizia Nanni ,  Laura Marcheschi ,  Chiara Marcheschi

IPC: B01J19/00

CPC classification number: B01J2/16

Abstract: A system (1) for the treatment of powdered material, in particular pharmaceutical powders, comprising, with the possibility of suitable connection between them using pipe means (4), at least a first operating unit (2) designed for mixing the powdered material with other substances to obtain a predetermined mixture, and at least a second operating unit (3) designed for subjecting the mixture to a fluid bed type treatment. The first unit (2) is supported in such a way that it is mobile relative to the second unit (3); there being means (8, 7, 13) for supporting and moving the first unit (2), for moving the first unit (2) alternatively in a predetermined direction (F) relative to the second unit (3), between a first and a second operating position (A, B).

Abstract translation: 一种用于处理粉末材料，特别是药物粉末的系统（1），其包括可能使用管道装置（4）在它们之间适当连接的至少第一操作单元（2），所述第一操作单元（2）被设计用于将粉末材料与 其他物质以获得预定的混合物，以及至少第二操作单元（3），其设计用于使混合物进行流化床型处理。 第一单元（2）以相对于第二单元（3）移动的方式被支撑; 存在用于支撑和移动第一单元（2）的装置（8,7,13），用于相对于第二单元（3）在预定方向（F）上交替地移动第一单元（2），第一单元 第二操作位置（A，B）。

公开(公告)号：US20070184143A1

公开(公告)日：2007-08-09

申请号：US11578969

申请日：2006-02-02

Applicant: Fabriano Ferrini ,  Roberto Trebbi

Inventor： Fabriano Ferrini ,  Roberto Trebbi

IPC: B30B11/08

CPC classification number: B30B15/32 ,  B30B11/08

Abstract: A tablet press machine (1) comprises a covering structure (100) enclosing in a delimited space a rotary turret (T) for the production of tablets (C); hopper means (2) for containing pharmaceutical material (M) in powder or granular form to be pressed; rotary disc means (3, 5, 6) equipped with matrices (4) designed to contain defined quantities or doses of the pharmaceutical material (M) fed to them by the hopper means (2); reciprocating punch means (7; 7a, 7b) for compressing the doses inside the matrices (4); at least a first and a second station (Z1, Z2) for completing the tablets (C) formed in respective first and second forming lines (A1, A2); the first and second completing stations (Z1, Z2) are positioned at a defined angular interval from each other on the turret (T); the machine (1) further comprises a single outfeed station (Z3) outside the structure (100) where the tablets (C) are made by the first and second forming lines (A1, A2); and conveyor means (8) coupled with the turret (T) and defining a channel for feeding the tablets (C) formed in the first line (A1) and completed in the first completing station (Z1) to the outfeed station (Z3) along a path (P) running parallel to and alongside the second line (A2).

Abstract translation: 一种压片机（1）包括一封闭结构（100），该覆盖结构（100）包围在限定空间中，用于生产片剂（C）的旋转转塔（T）; 用于容纳待压制的粉末或颗粒形式的药物材料（M）的料斗装置（2） 旋转盘装置（3,5,6）装备有设计成容纳通过料斗装置（2）供给给它们的限定数量或剂量的药物材料（M）的基质（4）; 用于压缩基质（4）内的剂量的往复冲击装置（7; 7a，7b）; 至少第一和第二工位（Z 1，Z 2），用于完成在相应的第一和第二成形线（A 1，A 2）中形成的片剂（C）; 第一和第二完成站（Z 1，Z 2）在转台（T）上彼此定义成角度间隔; 机器（1）还包括在结构（100）外部的单个出料站（Z 3），其中片剂（C）由第一和第二成形线（A 1，A 2）制成; 和传送装置（8），其与所述转台（T）联接并且限定用于将形成在所述第一线路（A 1）中的并且在所述第一完成站点（Z 1）中完成的所述片剂（C）馈送到所述出口站 3）沿着平行于并与第二线（A 2）并行的路径（P）。

公开(公告)号：US20060147573A1

公开(公告)日：2006-07-06

申请号：US10546272

申请日：2005-01-06

Applicant: Sauro Rossi ,  Roberto Trebbi

Inventor： Sauro Rossi ,  Roberto Trebbi

IPC: B30B11/10

CPC classification number: B30B11/08

Abstract: A tablet press (1) of the type with a rotary turret (3) for the production of tablets comprises a hopper (2) containing the pharmaceutical product in powder or granular form to be compressed; a rotary disc (4) equipped with matrices (5) designed to contain defined quantities of the pharmaceutical product fed to them by the hopper (2); reciprocating punches (8, 9) for compressing the powdered product and constituting a plurality of compressing operating stations (10); at least one set (A) f operating stations (10a) having a modified structure to inhibit operation, each modified structure station (10a) comprising barrier means (11) designed to be fitted at the matrices (5) in such a way as to prevent the passage of the product from the hopper (2) to the matrices (5), and opposing elastic means (12) designed to be coupled to, and act in conjunction with, the reciprocating punches (8, 9) and with the barrier means (11) in order to simulate the presence of powdered product.

Abstract translation: 具有用于制备片剂的旋转转台（3）的类型的压片机（1）包括含有要压缩的粉末或颗粒形式的药物产品的料斗（2） 装备有矩阵（5）的旋转盘（4），其设计成容纳由料斗（2）供给到其中的限定量的药物产品; 用于压缩粉末产品并构成多个压缩操作站（10）的往复冲头（8,9）; 至少一组（A）f操作站（10a）具有修改的结构以禁止操作，每个修改的结构站（10a）包括被设计为安装在矩阵（5）处的阻挡装置（11） 防止产品从料斗（2）通过到基质（5）和相对的弹性装置（12），该弹性装置被设计成与往复式冲头（8,9）结合并与其结合 意味着（11），以模拟粉状产品的存在。

公开(公告)号：US20060124053A1

公开(公告)日：2006-06-15

申请号：US10542954

申请日：2004-02-03

Applicant: Roberto Trebbi

Inventor： Roberto Trebbi

IPC: A01J27/02

CPC classification number: B05B13/0257 ,  A23G3/26 ,  A61J3/005 ,  B01J2/006 ,  B01J2/12

Abstract: A machine (100) for the treatment of pharmaceutical products (P) comprises a pan (2) that revolves about an axis of rotation (X) and a dispensing unit (3) designed to disperse a coating material inside the pan (2) over a mass (M) of the products (P) located in the pan (2). The pan (2) has an opening (7) for feeding the products to be treated (P) into the pan (2), and an opening (8) for feeding the products (PT) already treated with the coating material out of the pan (2), the infeed opening (7) and the outfeed opening (8) being separate and independent of each other. A portion (K) of the inside surface of the pan (2) is equipped with at least one helical flow regulating fin (4, 5, 6) designed to facilitate inflow (F3) of the products to be treated (P) into the pan (2) during the feeding of the products (P) into the pan (2) through the infeed opening (7) when the pan (2) itself revolves in a first direction of rotation (F1), and to cause outflow (F4) of the treated products (PT) from the pan (2) during the outfeed of the treated products (PT) from the pan (2) through the outfeed opening (8) when the pan (2) itself revolves in a second direction of rotation (F2), opposite to the first direction of rotation (F1).

Abstract translation: 用于治疗药物（P）的机器（100）包括围绕旋转轴线（X）旋转的盘（2）和设计成将覆盖材料分散在盘（2）内部的涂覆材料的分配单元（3） 位于锅（2）中的产品（P）的质量（M）。 盘（2）具有用于将待处理产品（P）进给到锅（2）中的开口（7），以及用于将已经用涂层材料处理的产品（PT）进给的开口（8） 平底锅（2），进料口（7）和出料口（8）彼此分离和独立。 盘（2）的内表面的一部分（K）配备有至少一个螺旋流量调节翅片（4,5,6），其设计成便于待处理产品（P）的流入（F 3）进入 在锅（2）本身沿第一旋转方向（F 1）旋转时，通过进料口（7）将产品（P）进给到盘（2）期间的锅（2） （2）在从锅（2）通过出料口（8）出来时从处理过的产品（PT）中的处理产品（PT）的出口（F 4） 第二旋转方向（F 2），与第一旋转方向（F 1）相反。