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公开(公告)号：US06303635B1
公开(公告)日：2001-10-16
申请号：US09384214
申请日：1999-08-27
IPC分类号： A61K31445
CPC分类号： C07D211/70 , A61K31/451 , A61K31/4545
摘要： A thrombolytic drug containing cyproheptadine, a compound of the following formula or a salt thereof as the active ingredient is provided. This thrombolytic drug has a function of accelerating the release of a tissue plasminogen activator (t-PA), while exerting no effect on the release of type-1 plasminogen activator inhibitor (PAI-1) which deactivates t-PA or reducing the release thereof. wherein n represents an integer of 2 or 3, Y represents a hydrogen atom or halogen atom, and X represents a formyl group, acetyl group or hydrogen atom.
摘要翻译： 提供含有赛庚啶的溶栓药物，下式的化合物或其盐作为活性成分。 该溶栓药物具有促进组织纤溶酶原激活物（t-PA）释放的功能，而对t-PA失活或减少其释放的1型纤溶酶原激活物抑制剂（PAI-1）的释放没有影响 其中n表示2或3的整数，Y表示氢原子或卤素原子，X表示甲酰基，乙酰基或氢原子。
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12.发明授权公开(公告)号：US06262076B1
公开(公告)日：2001-07-17
申请号：US09493252
申请日：2000-01-28
IPC分类号： A61K31445
CPC分类号： A61K31/445 , Y10S514/866
摘要： Disclosed is a pharmaceutical composition for use in the treatment of diabetic neuropathy, which comprises a piperidine derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein n is an integer of 2 of 3, Y is a hydrogen atom or halogen atom, and X is a formyl group, acetyl group or hydrogen atom.
摘要翻译： 公开了用于治疗糖尿病性神经病的药物组合物，其包含由以下通式（1）表示的哌啶衍生物或其药学上可接受的盐作为有效成分：其中n为3的整数，Y为 是氢原子或卤原子，X是甲酰基，乙酰基或氢原子。
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13.发明授权公开(公告)号：US06280731B1
公开(公告)日：2001-08-28
申请号：US09299016
申请日：1999-04-26
IPC分类号： A61K39395
摘要： A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.
摘要翻译： 具有与人血管性血友病因子的反应性的单克隆抗体，其具有抑制人血小板的RIPA（瑞斯托菌素诱导的血小板聚集），BIPA（博来敏素诱导的血小板聚集）和SIPA（剪切应力诱导的血小板聚集）的作用， 并且在药物有效剂量中不表现出血作用以显示抗血栓形成作用，用作抗血栓形成剂的活性成分。
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公开(公告)号：US5229400A
公开(公告)日：1993-07-20
申请号：US770892
申请日：1991-10-04
IPC分类号： C07D211/22 , C07D211/32 , C07D211/70 , C07D295/192 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/04 , C07D521/00
CPC分类号： C07D295/192 , C07D211/22 , C07D211/32 , C07D211/70 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/04
摘要： A piperidine derivative of general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein ##STR2## is any of several specified aromatic-containing groups; X is selected from one of several hetero atom-containing groups or C.sub.2 alkylene or a cyano-containing group; and Q is phenyl, cyclohexyl, piperidinyl, tetrahydropyranyl, pyridyl, pyrrolyl, N-methylpyrrolyl, thienyl, furyl, 1-hexyl, or cyano; from 1 to 3 hydrogen atoms in Q may be independently substituted by alkyl of from 1 to 3 carbon atoms, perfluoroalkyl of from 1 to 3 carbon atoms, acylamino of from 1 to 6 carbon atoms, perfluoroacylamino of from 1 to 3 carbon atoms, alkoxy of from 1 to 3 carbon atoms, alkanesulfonylamino of from 1 to 3 carbon atoms, perfluoroalkanesulfonylamino of from 1 to 3 carbon atoms, acetoxy of from 1 to 3 carbon atoms, aminocarbonyl, aminosulfonyl, fluoro, chloro, cyano, hydroxy, nitro, amino, imidazolylmethyl, cinnamoylamino, p-fluorobenzoyl, cyanomethyl, cyanoethyl, methoxyacetoxy, alkoxycarbonyl of from 1 to 3 carbon atoms; 1 is an integer of from 0 to 1; m is an integer of from 0 to 1; n is an integer of from 0 to 6.The derivatives are useful as antiarrhythmic agents.
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