公开(公告)号：US20210233609A1

公开(公告)日：2021-07-29

申请号：US17226580

申请日：2021-04-09

Applicant: SEQUENOM, INC.

Inventor： Lin TANG ,  Cosmin DECIU

IPC: G16B20/00 ,  C12Q1/6869 ,  C12Q1/6874

Abstract: Provided in part herein are methods and processes that can be used for non-invasive assessment of a genetic variation which can lead to diagnosis of a particular medical condition or conditions. Such methods and processes can, for example, identify dissimiliarities or similarities for one or more features between a subject data set and a reference data set, generate a multidimensional matrix, reduce the matrix into a representation and classify the representation into one or more groups. Methods and processes described herein are applicable to data in biotechnology and other fields.

公开(公告)号：US20210174894A1

公开(公告)日：2021-06-10

申请号：US17109723

申请日：2020-12-02

Applicant: SEQUENOM, INC.

Inventor： Zeljko DZAKULA ,  Cosmin DECIU ,  Chen ZHAO

IPC: G16B20/00 ,  G16B40/00 ,  G16B30/00 ,  G06F17/18

Abstract: A method and system for analyzing circulating cell-free nucleic acids from a pregnant female with reduced bias. Counts of sequence reads mapped to portions of a reference genome are obtained. A regression model is generated that models the relationship between the counts and the GC content. The read counts are normalized according to the regression model to remove the GC bias. The normalized counts are used for further analysis, such as the detection of fetal aneuploidy.

公开(公告)号：US20170351811A1

公开(公告)日：2017-12-07

申请号：US15329016

申请日：2015-07-29

Applicant: SEQUENOM, INC.

Inventor： Chen ZHAO ,  Cosmin DECIU ,  Dirk Johannes VAN DEN BOOM

IPC: G06F19/24 ,  C12Q1/68

CPC classification number: G16B40/00 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/156 ,  G16B20/00 ,  G16B30/00

Abstract: Methods for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information, in particular length of fragments in circulating cell-free nucleic acids and compares the number of counts from fragments with different length.

公开(公告)号：US20150005176A1

公开(公告)日：2015-01-01

申请号：US14311070

申请日：2014-06-20

Applicant: SEQUENOM, INC.

Inventor： Sung K. KIM ,  Gregory HANNUM ,  Jennifer GEIS ,  Cosmin DECIU

IPC: G06F19/22 ,  G06F19/00

CPC classification number: G16B30/00 ,  C12Q1/6816 ,  C12Q1/6869 ,  C12Q1/6872 ,  G06F19/34 ,  G16B20/00 ,  C12Q2537/165

Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of genetic variations.

Abstract translation: 本文提供了用于遗传变异的非侵入性评估的方法，过程，系统，机器和装置。

公开(公告)号：US20130309666A1

公开(公告)日：2013-11-21

申请号：US13779638

申请日：2013-02-27

Applicant: Sequenom, Inc.

Inventor： Cosmin DECIU ,  Zeljko Dzakula

IPC: G06F19/22

CPC classification number: G16B30/00 ,  G16B20/00 ,  G16B25/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20130150253A1

公开(公告)日：2013-06-13

申请号：US13754817

申请日：2013-01-30

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Mathias EHRICH ,  Dirk J. Van Den Boom ,  Zeljko Dzakula

IPC: C12Q1/68

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract translation: 本文提供了用于遗传变异的非侵入性评估的方法，过程和装置。

公开(公告)号：US20240161866A1

公开(公告)日：2024-05-16

申请号：US18459747

申请日：2023-09-01

Applicant: SEQUENOM, INC.

Inventor： Chen ZHAO ,  Cosmin DECIU ,  Dirk Johannes VAN DEN BOOM

IPC: G16B20/10 ,  C12Q1/6883 ,  G16B20/00 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10 ,  G16B40/00

CPC classification number: G16B20/10 ,  C12Q1/6883 ,  G16B20/00 ,  G16B20/20 ,  G16B30/00 ,  G16B30/10 ,  G16B40/00 ,  C12Q2600/112 ,  C12Q2600/156

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of nucleic acid fragment length information.

公开(公告)号：US20230112134A1

公开(公告)日：2023-04-13

申请号：US18080620

申请日：2022-12-13

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Zeljko Jovan DZAKULA ,  Mathias EHRICH ,  Sung Kyun KIM

IPC: C12Q1/6827 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20230070843A1

公开(公告)日：2023-03-09

申请号：US17933938

申请日：2022-09-21

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Zeljko DZAKULA

IPC: C12Q1/683 ,  G16B20/00 ,  C12Q1/6827 ,  G16B20/10 ,  G16B30/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20210238669A1

公开(公告)日：2021-08-05

申请号：US17226529

申请日：2021-04-09

Applicant: SEQUENOM, INC.

Inventor： Dirk Johannes VAN DEN BOOM ,  Charles R. CANTOR ,  Sung Kyun KIM ,  Zeljko DZAKULA ,  Cosmin DECIU

IPC: C12Q1/6869 ,  G16B20/00 ,  C12Q1/6827

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.