公开(公告)号：US20190309351A1

公开(公告)日：2019-10-10

申请号：US16395658

申请日：2019-04-26

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Zeljko Jovan DZAKULA ,  Mathias EHRICH ,  Sung Kyun KIM

IPC: C12Q1/6827 ,  G16B20/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20130189684A1

公开(公告)日：2013-07-25

申请号：US13797377

申请日：2013-03-12

Applicant: SEQUENOM, INC.

Inventor： Mathias EHRICH ,  Taylor JENSEN

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/154

Abstract: The technology relates in part to selection, quantification and use of particular nucleic acid markers. In some embodiments, such markers are particular epigenetic markers, and sometimes each marker is a particular methylation state of a nucleic acid locus.

Abstract translation: 该技术部分涉及特定核酸标记的选择，定量和使用。 在一些实施方案中，这样的标记是特定的表观遗传标记，并且有时每个标记是核酸基因座的特定甲基化状态。

公开(公告)号：US20130085681A1

公开(公告)日：2013-04-04

申请号：US13669136

申请日：2012-11-05

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Zeljko DZAKULA ,  Mathias EHRICH ,  Sung Kyun KIM

IPC: G06F19/18

CPC classification number: C12Q1/6827 ,  G06F19/18 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20240371468A1

公开(公告)日：2024-11-07

申请号：US18436637

申请日：2024-02-08

Applicant: SEQUENOM, INC.

Inventor： Sung KIM ,  Taylor Jacob JENSEN ,  Mathias EHRICH

IPC: G16B20/20 ,  G16B20/00 ,  G16B20/10 ,  G16B30/00 ,  G16B30/10 ,  G16B30/20

Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of chromosome alterations.

公开(公告)号：US20220403468A1

公开(公告)日：2022-12-22

申请号：US17342055

申请日：2021-06-08

Applicant: SEQUENOM, INC.

Inventor： Taylor Jacob JENSEN ,  Mathias EHRICH

IPC: C12Q1/6883 ,  C12Q1/6811

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20220098644A1

公开(公告)日：2022-03-31

申请号：US17502842

申请日：2021-10-15

Applicant: SEQUENOM, INC.

Inventor： Mathias EHRICH ,  Guy DEL MISTRO ,  Cosmin DECIU ,  Yong Qing CHEN ,  Ron Michael McCULLOUGH ,  Roger Chan TIM

IPC: C12Q1/686 ,  G16B25/00 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B25/20

Abstract: Provided are methods for identifying the presence or absence of a chromosome abnormality by which a cell-free sample nucleic acid from a subject is analyzed. In certain embodiments, provided are methods for identifying the presence or absence of a fetal chromosome abnormality in a nucleic acid from cell-free maternal blood.

公开(公告)号：US20160292356A1

公开(公告)日：2016-10-06

申请号：US15026939

申请日：2014-10-03

Applicant: SEQUENOM, INC.

Inventor： Sung KIM ,  Taylor Jacob JENSEN ,  Mathias EHRICH

IPC: G06F19/22

CPC classification number: G16B30/00 ,  G16B20/00

Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of chromosome alterations.

Abstract translation: 本文提供了用于非侵入性评估染色体改变的方法，过程，系统，机器和装置。

公开(公告)号：US20130150253A1

公开(公告)日：2013-06-13

申请号：US13754817

申请日：2013-01-30

Applicant: SEQUENOM, INC.

Inventor： Cosmin DECIU ,  Mathias EHRICH ,  Dirk J. Van Den Boom ,  Zeljko Dzakula

IPC: C12Q1/68

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract translation: 本文提供了用于遗传变异的非侵入性评估的方法，过程和装置。

公开(公告)号：US20200058372A1

公开(公告)日：2020-02-20

申请号：US16544316

申请日：2019-08-19

Applicant: SEQUENOM, INC.

Inventor： Sung KIM ,  Taylor Jacob JENSEN ,  Mathias EHRICH

IPC: G16B30/00 ,  G16B20/00

Abstract: Provided herein are methods, processes, systems, machines and apparatuses for non-invasive assessment of chromosome alterations.

公开(公告)号：US20170314071A1

公开(公告)日：2017-11-02

申请号：US15428659

申请日：2017-02-09

Applicant: SEQUENOM, INC.

Inventor： Mathias EHRICH ,  Anders Olof Herman NYGREN ,  Tyler Jacob JENSEN

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6888 ,  C12Q2600/16 ,  C12Q2537/164 ,  C12Q2522/101 ,  C12Q2565/501

Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.