公开(公告)号：US20180249926A1

公开(公告)日：2018-09-06

申请号：US15756221

申请日：2016-08-31

Applicant: STC.UNM

Inventor： Shihoko Kimura-Ohba ,  Laurel Sillerud

IPC: A61B5/055 ,  A61B5/00

Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.

公开(公告)号：US09958516B2

公开(公告)日：2018-05-01

申请号：US14226572

申请日：2014-03-26

Applicant: STC.UNM ,  ABQMR, Inc. ,  Sandia Corporation

Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

IPC: G01R33/32 ,  G01R33/30 ,  G01R33/34 ,  G01R33/341 ,  G01R33/465 ,  G01N24/08 ,  G01N33/543 ,  G01N33/553 ,  B82Y15/00 ,  G01R33/28 ,  G01R33/56

CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.