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    BIOLOGICAL DETECTOR AND METHOD
    1.
    发明申请
    BIOLOGICAL DETECTOR AND METHOD 有权
    生物检测和方法

    公开(公告)号：US20140295486A1

    公开(公告)日：2014-10-02

    申请号：US14226572

    申请日：2014-03-26

    Applicant: STC.UNM

    Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

    IPC: G01R33/32

    CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

    Abstract translation: 生物检测器包括用于接收含有一个或多个待纳入检测体的磁性纳米颗粒标记的生物体的流体的导管，以及一个用于建立其中设置导管的低磁场的永磁体或电磁体。 微线圈靠近导管设置，以允许通过NMR光谱法检测流体中是否存在一个或多个磁性标记的生物体的频率。

    Biological detector and method
    4.
    发明授权
    Biological detector and method 有权
    生物检测仪及方法

    公开(公告)号：US08698494B2

    公开(公告)日：2014-04-15

    申请号：US13776580

    申请日：2013-02-25

    Applicant: STC.UNM

    Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

    IPC: G01V3/00

    CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

    Abstract translation: 生物检测器包括用于接收含有一个或多个待纳入检测体的磁性纳米颗粒标记的生物体的流体的导管，以及一个用于建立其中设置导管的低磁场的永磁体或电磁体。 微线圈靠近导管设置，以允许通过NMR光谱法检测流体中是否存在一个或多个磁性标记的生物体的频率。

    Fractional anisotropy in MRI as an indicator of reversible pathology
    6.
    发明授权
    Fractional anisotropy in MRI as an indicator of reversible pathology 有权

    公开(公告)号：US10827946B2

    公开(公告)日：2020-11-10

    申请号：US15756221

    申请日：2016-08-31

    Applicant: STC.UNM

    Inventor： Shihoko Kimura-Ohba ,  Laurel Sillerud

    IPC: A61B5/055 ,  A61B6/03 ,  G06T7/48 ,  A61B5/00 ,  G06T7/00 ,  G01R33/563

    Abstract: The present invention concerns a method for determining whether brain regions of interest having reversible or irreversible pathology. The method includes acquiring over a predetermined period of time a plurality of magnetic resonance imaging (MRI) images for each brain region of interest; analyzing the MRI images to obtain quantitative measurements of the fractional anisotropy (FA) for each brain region of interest and determining that brain regions of interest have reversible pathology when the measured FA increases and then decreases over the predetermined period of time.

    Physical removal of biological agents detected by a magnecytometer
    7.
    发明授权
    Physical removal of biological agents detected by a magnecytometer 有权
    物理去除由磁力计检测的生物制剂

    公开(公告)号：US09110068B2

    公开(公告)日：2015-08-18

    申请号：US14298148

    申请日：2014-06-06

    Applicant: STC.UNM

    Inventor： Laurel Sillerud

    IPC: G01N33/53 ,  G01N33/574 ,  G01N33/543 ,  A61M1/34

    CPC classification number: G01N33/57438 ,  A61M1/3486 ,  G01N24/08 ,  G01N33/54306 ,  G01N33/54326 ,  G01N33/54373 ,  G01N33/57488 ,  G01R33/281 ,  G01R33/302 ,  G01R33/448 ,  G01R33/465 ,  Y02A50/58

    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal. The system and method also include a container having a binding agent therein that has an affinity for the analyte or foreign agent that is used to remove the foreign agent from a patient's blood or plasma. Blood or plasma is shunted through the container to remove or reduce the foreign agent by extracorporeal circulation.

    Abstract translation: 用于分析具有NMR信号的液体样品的系统和方法，所述液体具有响应于分析物存在的磁场。 包括具有适于容纳液体并对液体施加磁场的测试部分的NMR装置。 复合物由具有与分析物结合的场梯度的共轭物构成，其在测试部分中具有足够的量级以猝灭液体的NMR信号，由此通过不存在NMR信号来确定复合物的存在。 该系统和方法还包括其中具有粘合剂的容器，其对于用于从患者血液或血浆中除去外来试剂的分析物或外来物质具有亲和力。 血液或血浆通过容器分流，以通过体外循环除去或减少外来物质。

    Magnecytometer for the detection of one or more analytes
    8.
    发明授权
    Magnecytometer for the detection of one or more analytes 有权
    用于检测一种或多种分析物的Magnecytometer

    公开(公告)号：US09110067B2

    公开(公告)日：2015-08-18

    申请号：US14213301

    申请日：2014-03-14

    Applicant: STC.UNM

    Inventor： Laurel Sillerud

    IPC: G01N24/08 ,  G01N33/574 ,  G01N33/543 ,  G01R33/30

    CPC classification number: G01N33/57438 ,  G01N24/08 ,  G01N33/54306 ,  G01N33/574 ,  G01R33/307

    Abstract: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid. A complex comprised of a conjugate having a field gradient bound to the analyte that is of sufficient magnitude to quench the NMR signal of the liquid when in the test section whereby the presence of the complex is determined by the absence of the NMR signal.

    Abstract translation: 用于分析具有NMR信号的液体样品的系统和方法，所述液体具有响应于分析物存在的磁场。 包括具有适于容纳液体并对液体施加磁场的测试部分的NMR装置。 复合物由具有与分析物结合的场梯度的共轭物构成，其在测试部分中具有足够的量级以猝灭液体的NMR信号，由此通过不存在NMR信号来确定复合物的存在。

    BIOLOGICAL DETECTOR AND METHOD
    9.
    发明申请
    BIOLOGICAL DETECTOR AND METHOD 有权
    生物检测和方法

    公开(公告)号：US20130169276A1

    公开(公告)日：2013-07-04

    申请号：US13776580

    申请日：2013-02-25

    Applicant: STC.UNM

    Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

    IPC: G01R33/30 ,  G01R33/465

    CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

    Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

    Abstract translation: 生物检测器包括用于接收含有一个或多个待纳入检测体的磁性纳米颗粒标记的生物体的流体的导管，以及一个用于建立其中设置导管的低磁场的永磁体或电磁体。 微线圈靠近导管设置，以允许通过NMR光谱法检测流体中是否存在一个或多个磁性标记的生物体的频率。

    Quantitative [Fe]-MRI (femri) of anti-PSMA-conjugated SPIONs based on PSMA expression levels
    10.
    发明授权
    Quantitative [Fe]-MRI (femri) of anti-PSMA-conjugated SPIONs based on PSMA expression levels 有权

    公开(公告)号：US10466326B2

    公开(公告)日：2019-11-05

    申请号：US15574431

    申请日：2016-05-13

    Applicant: STC.UNM

    Inventor： Laurel Sillerud

    IPC: G01R33/56 ,  G01R33/465 ,  B82Y15/00 ,  G06T7/00

    Abstract: A method of measuring the concentration of a magnetic material in an object using magnetic resonance imaging comprising administering magnetic material to the object; obtaining a set of T1-weighted and T2-weighted images of the object in order to determine a background magnetic resonance imaging signal intensity and measurements of the background nuclear magnetic relaxation times (T1, T2) of the object without magnetic material; and obtaining a set of T1-weighted and T2-weighted magnetic resonance images of the object with magnetic materials added; measuring effect of magnetic material on the relaxation times; and converting the T1-weighted and T2-weighted images into a set of contrast images which are subtracted from each other to yield a contrast difference image proportional to the concentration of the magnetic material.

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