公开(公告)号：US20140107175A1

公开(公告)日：2014-04-17

申请号：US14062626

申请日：2013-10-24

Applicant: SUNOVION PHARMACEUTICALS INC.

Inventor： Liming SHAO ,  Fengjiang Wang ,  Scott C. Malcolm ,  Michael C. Hewitt

IPC: C07D209/52

CPC classification number: C07D209/44 ,  A61K31/4035 ,  C07D209/08 ,  C07D209/52

Abstract: Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit re-uptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.

Abstract translation: 本文提供的是双环化合物及其合成方法。 本文提供的化合物可用于治疗，预防和/或管理各种神经障碍。 本文提供的化合物抑制内源性单胺如多巴胺，5-羟色胺和去甲肾上腺素（例如，从突触裂缝）的再摄取并调节一种或多种单胺转运蛋白。 还提供了含有这些化合物的药物制剂。

公开(公告)号：US20190125722A1

公开(公告)日：2019-05-02

申请号：US16117450

申请日：2018-08-30

Applicant: Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

Inventor： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC: A61K31/381 ,  C07D495/20 ,  C07D495/04 ,  C07D333/78 ,  C07D333/76 ,  A61K31/435 ,  C07D277/60 ,  A61K45/06 ,  A61K31/55 ,  C07D333/54

Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20160083399A1

公开(公告)日：2016-03-24

申请号：US14950834

申请日：2015-11-24

Applicant: PGI Drug Discovery LLC ,  Sunovion Pharmaceuticals, Inc.

Inventor： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC: C07D495/04

CPC classification number: A61K31/381 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20

Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20140256712A1

公开(公告)日：2014-09-11

申请号：US14205859

申请日：2014-03-12

Applicant: Psychogenics Inc. ,  Sunovion Pharmaceuticals Inc.

Inventor： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC: C07D495/20 ,  C07D495/04

CPC classification number: A61K31/381 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20

Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Abstract translation: 本文提供多环化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。