公开(公告)号：US20140256712A1

公开(公告)日：2014-09-11

申请号：US14205859

申请日：2014-03-12

申请人： Psychogenics Inc. ,  Sunovion Pharmaceuticals Inc.

发明人： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC分类号： C07D495/20 ,  C07D495/04

CPC分类号： A61K31/381 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20

摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

摘要翻译： 本文提供多环化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。

公开(公告)号：US20180118727A1

公开(公告)日：2018-05-03

申请号：US15851836

申请日：2017-12-22

申请人： Sunovion Pharmaceuticals Inc.

发明人： John Emmerson CAMPBELL ,  Una CAMPBELL ,  Taleen G. HANANIA ,  Liming SHAO

IPC分类号： C07D409/04 ,  C07D491/048 ,  C07D495/04 ,  C07D405/04 ,  C07D409/14

CPC分类号： C07D409/04 ,  C07D405/04 ,  C07D409/14 ,  C07D491/048 ,  C07D495/04

摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20200277286A1

公开(公告)日：2020-09-03

申请号：US16722048

申请日：2019-12-20

申请人： Sunovion Pharmaceuticals Inc.

发明人： John Emmerson CAMPBELL ,  Una CAMPBELL ,  Taleen G. HANANIA ,  Liming SHAO

IPC分类号： C07D409/04 ,  C07D409/14 ,  C07D491/048 ,  C07D495/04 ,  C07D405/04

摘要： Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20220387382A1

公开(公告)日：2022-12-08

申请号：US17574702

申请日：2022-01-13

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC分类号： A61K31/381 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06

摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20210267938A1

公开(公告)日：2021-09-02

申请号：US16952401

申请日：2020-11-19

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC分类号： A61K31/381 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06

摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20200323819A1

公开(公告)日：2020-10-15

申请号：US16791118

申请日：2020-02-14

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC分类号： A61K31/381 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06

摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20190125722A1

公开(公告)日：2019-05-02

申请号：US16117450

申请日：2018-08-30

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC分类号： A61K31/381 ,  C07D495/20 ,  C07D495/04 ,  C07D333/78 ,  C07D333/76 ,  A61K31/435 ,  C07D277/60 ,  A61K45/06 ,  A61K31/55 ,  C07D333/54

摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

公开(公告)号：US20160083399A1

公开(公告)日：2016-03-24

申请号：US14950834

申请日：2015-11-24

申请人： PGI Drug Discovery LLC ,  Sunovion Pharmaceuticals, Inc.

发明人： Liming SHAO ,  John Emmerson CAMPBELL ,  Michael Charles HEWITT ,  Una CAMPBELL ,  Taleen G. HANANIA

IPC分类号： C07D495/04

CPC分类号： A61K31/381 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06 ,  C07D277/60 ,  C07D333/54 ,  C07D333/76 ,  C07D333/78 ,  C07D495/04 ,  C07D495/20

摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.