公开(公告)号：US07485420B2

公开(公告)日：2009-02-03

申请号：US10920119

申请日：2004-08-16

Applicant: Sanford D. Markowitz

Inventor： Sanford D. Markowitz

IPC: C12Q1/68

CPC classification number: G01N33/57419 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/154 ,  G01N33/5011

Abstract: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.

Abstract translation: 本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。 在波形蛋白相关性肿瘤如结肠瘤形成中观察到波形蛋白核苷酸序列的差异甲基化。

公开(公告)号：US08497084B2

公开(公告)日：2013-07-30

申请号：US12774641

申请日：2010-05-05

Applicant: Sanford D. Markowitz ,  Monica Bertagnolli

Inventor： Sanford D. Markowitz ,  Monica Bertagnolli

IPC: C12Q1/32

CPC classification number: A61K39/395 ,  A61K31/19 ,  A61K31/415 ,  A61K31/517 ,  A61K31/60 ,  A61K31/7088 ,  A61K38/02 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/57419 ,  G01N2333/902 ,  G01N2800/52

Abstract: The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the prevention of cancer, e.g., colon cancer, by increasing the levels or activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH). The disclosure also provides a method of identifying compounds that upregulate or reactivate 15-PGDH. The disclosure also provides a method of identifying an individual suitable for treatment with a non-steroidal anti-inflammatory agent in the treatment or prevention of colon cancer.

公开(公告)号：US08415100B2

公开(公告)日：2013-04-09

申请号：US13167670

申请日：2011-06-23

Applicant: Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

Inventor： Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C07H21/04 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.

Abstract translation: 本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。 已经观察到波形蛋白核苷酸序列的差异甲基化在波形蛋白相关瘤形成中，例如上，下胃肠道，胰腺和/或膀胱的瘤形成。

公开(公告)号：US20120094287A1

公开(公告)日：2012-04-19

申请号：US13167670

申请日：2011-06-23

Applicant: Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

Inventor： Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

IPC: C12Q1/68 ,  G01N33/566

CPC classification number: C12Q1/6886 ,  C07H21/04 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.

Abstract translation: 本申请描述了用于检测和治疗波形蛋白相关瘤形成的方法和组合物。 已经观察到波形蛋白核苷酸序列的差异甲基化在波形蛋白相关瘤形成中，例如上，下胃肠道，胰腺和/或膀胱的瘤形成。

公开(公告)号：US07741040B2

公开(公告)日：2010-06-22

申请号：US11484025

申请日：2006-07-07

Applicant: Sanford D. Markowitz

Inventor： Sanford D. Markowitz

IPC: C12Q1/68

CPC classification number: C12N15/8509 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/4702 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154

Abstract: In certain aspects, the invention provides isolated SLC5A8 (also referred to as Hui1) nucleic acid molecules, which encode novel sodium solute symporter members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLC5A8 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLC5A8 gene has been introduced or disrupted. The invention still further provides isolated SLC5A8 proteins, fusion proteins, antigenic peptides, and anti-SLC5A8 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. In other aspects, the invention provides methods and compositions for detecting and treating SLC5A8-associated cancer. Differential methylation of the SLC5A8 nucleotide sequences has been observed in SLC5A8-associated cancer, such as colon cancer, breast cancer, thyroid cancer, or stomach cancer.

Abstract translation: 在某些方面，本发明提供了分离的SLC5A8（也称为Hui1）核酸分子，其编码新的钠溶质对转体成员。 本发明还提供了反义核酸分子，含有SLC5A8核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏SLC5A8基因的非人转基因动物。 本发明还进一步提供了分离的SLC5A8蛋白，融合蛋白，抗原肽和抗SLC5A8抗体。 还提供了利用本发明组合物的诊断方法。 在其它方面，本发明提供了用于检测和治疗SLC5A8相关癌症的方法和组合物。 已经在SLC5A8相关癌症如结肠癌，乳腺癌，甲状腺癌或胃癌中观察到SLC5A8核苷酸序列的差异甲基化。

公开(公告)号：US07432050B2

公开(公告)日：2008-10-07

申请号：US10266103

申请日：2002-10-07

Applicant: Sanford D. Markowitz

Inventor： Sanford D. Markowitz

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC classification number: G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  G01N33/57419 ,  Y10T436/143333

Abstract: This application describes methods and compositions for detecting and treating HLTF-associated neoplasia. Differential methylation of the HLTF nucleotide sequences has been observed in HLTF-associated neoplasia such as colon neoplasia.

Abstract translation: 本申请描述了用于检测和治疗HLTF相关瘤形成的方法和组合物。 已经在HLTF相关瘤变如结肠瘤形成中观察到HLTF核苷酸序列的差异甲基化。

公开(公告)号：US20110165567A1

公开(公告)日：2011-07-07

申请号：US12870674

申请日：2010-08-27

Applicant: Sanford D. Markowitz ,  Helen Moinova ,  Lois Myeroff ,  Jean-Pierre Issa ,  Osamu Maeda

Inventor： Sanford D. Markowitz ,  Helen Moinova ,  Lois Myeroff ,  Jean-Pierre Issa ,  Osamu Maeda

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/02

CPC classification number: C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/57419 ,  G01N2500/10 ,  G01N2800/56

Abstract: This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.

Abstract translation: 本申请描述了用于检测和治疗C6Orf150相关瘤形成的方法和组合物。 在C6Orf150相关的肿瘤形成例如结肠瘤形成中观察到C6Orf150核苷酸序列的差异甲基化。

公开(公告)号：US20110027283A1

公开(公告)日：2011-02-03

申请号：US12676817

申请日：2008-09-05

Applicant: Sanford D. Markowitz ,  Joseph Willis ,  Dawn Dawson

Inventor： Sanford D. Markowitz ,  Joseph Willis ,  Dawn Dawson

IPC: A61K39/395 ,  G01N33/68 ,  G01N33/566 ,  G01N33/574 ,  A61K38/02 ,  A61K31/7105 ,  A61K31/713 ,  A61K31/711 ,  A61P35/00

CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57442 ,  G01N33/57446 ,  G01N33/57449 ,  G01N33/57488 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/046

Abstract: This disclosure provides methods and compositions for inhibiting immune responses. The disclosure also provides methods and compositions for inhibiting graft rejection and promoting or prolonging graft survival.

Abstract translation: 本公开提供了用于抑制免疫应答的方法和组合物。 本公开还提供了用于抑制移植物排斥和促进或延长移植物存活的方法和组合物。

公开(公告)号：US20090311726A1

公开(公告)日：2009-12-17

申请号：US12386176

申请日：2009-04-13

Applicant: Sanford D. Markowitz

Inventor： Sanford D. Markowitz

IPC: G01N33/53

CPC classification number: C07K14/4748 ,  G01N33/57419 ,  G01N2500/00

Abstract: The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.

Abstract translation: 本公开尤其提供了用于分类患者的肿瘤状态的分子标记，在诊断测试中使用分子标记的方法，与分子标记相关的核酸和氨基酸序列，用于检测分子标记的试剂和方法 用于在高度平行的基因表达数据中鉴定候选分子标记。

公开(公告)号：US07118912B2

公开(公告)日：2006-10-10

申请号：US10274177

申请日：2002-10-18

Applicant: Sanford D. Markowitz

Inventor： Sanford D. Markowitz

IPC: C12N5/20

CPC classification number: C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/57419

Abstract: The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data.