公开(公告)号：US5665779A

公开(公告)日：1997-09-09

申请号：US256121

申请日：1994-06-24

申请人： Shinichi Kondo ,  Yoko Ikeda ,  Masa Hamada ,  Tomio Takeuchi ,  Hiroo Hoshino

发明人： Shinichi Kondo ,  Yoko Ikeda ,  Masa Hamada ,  Tomio Takeuchi ,  Hiroo Hoshino

IPC分类号： A61K31/16 ,  A61P31/12 ,  A61P31/18

CPC分类号： A61K31/16

摘要： D-.beta.-Lysylmethanediamine represented by the formula (I) ##STR1## or a salt or a hydrate thereof has now been found to have an activity of inhibiting the infection with AIDS virus (a virus causative of acquired human immunodeficiency syndrome), mamely HIV. A pharmaceutical composition comprising the above compound or a salt or hydrate thereof as active ingredient is provided and expectable as one of remedial agents for treating AIDS which is now thought to be difficult to cure.

摘要翻译： PCT No.PCT / JP92 / 01703 Sec。 371日期：1994年6月24日 102（e）日期1994年6月24日PCT提交1992年12月25日PCT公布。 公开号WO93 / 12776 日期：1993年7月8日现已发现由式（I）表示的β-L-亚磺酰基二胺或其盐或其水合物具有抑制艾滋病病毒感染的活性 获得性免疫缺陷综合征），艾滋病毒感染。 提供包含上述化合物或其盐或水合物作为活性成分的药物组合物，作为治疗目前认为难以治愈的AIDS的补救剂之一。

公开(公告)号：US5120717A

公开(公告)日：1992-06-09

申请号：US394539

申请日：1989-08-16

申请人： Tomio Takeuchi ,  Shinichi Kondo ,  Hiroo Hoshino

发明人： Tomio Takeuchi ,  Shinichi Kondo ,  Hiroo Hoshino

IPC分类号： C07H15/24 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/12 ,  A61P31/18 ,  C07H15/244

CPC分类号： A61K31/70 ,  C07H15/244 ,  Y10S514/934

摘要： Pharmaceutical compositions containing at least one of benanomicins A and B and their salts are now provided, which are useful to inhibit the infection of human T-cells with HIV, namely a virus causative of acquired human immunodeficiency syndrome (AIDS). Thus, benanomicins A and B as well as their salts are useful as antiviral agent against HIV.

公开(公告)号：US5093323A

公开(公告)日：1992-03-03

申请号：US459352

申请日：1989-12-29

申请人： Tomio Takeuchi ,  Shinichi Kondo ,  Shuichi Gomi ,  Hiroo Hoshino

发明人： Tomio Takeuchi ,  Shinichi Kondo ,  Shuichi Gomi ,  Hiroo Hoshino

IPC分类号： C07H15/24 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/12 ,  C07H15/244 ,  C07H15/256

CPC分类号： C07H15/244

摘要： As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus causative of acquired human immunodeficiency syndrome. N-acetylbenanomicin B may be prepared by acetylation of 4"-amino group of benanomicin B which is fermentatively produced by a new microorganism, MH193-16F4 strain of actinomycetes.