公开(公告)号：US20140242588A1

公开(公告)日：2014-08-28

申请号：US14350052

申请日：2012-10-05

Applicant: SEQUENOM, INC.

Inventor： Dirk Johannes Van Den Boom ,  Charles R. Cantor ,  Sung Kyun Kim ,  Zeljko Dzakula ,  Cosmin Deciu

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6827 ,  G16B20/00 ,  G16B30/00 ,  G16B40/00 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract translation: 本文提供的技术部分地涉及遗传变异的非侵入性评估的方法，过程和装置。

公开(公告)号：US20200232016A1

公开(公告)日：2020-07-23

申请号：US16715270

申请日：2019-12-16

Applicant: Sequenom, Inc.

Inventor： Charles R. Cantor

IPC: C12Q1/6818 ,  C12Q1/6816

Abstract: Provided herein are compositions and methods for analysis of nucleic acids, including, methods and compositions for genotyping, haplotyping, sequencing and performing other genetic and epigenetic analyses on nucleic acids, for example. In some embodiments, methods and compositions suitable for whole-genome sequencing on single molecules of nucleic acid are provided. In some embodiments, analysis of single molecules of nucleic acid are performed in conjunction with nanopores and/or nanopore devices.

公开(公告)号：US20200216885A1

公开(公告)日：2020-07-09

申请号：US16703357

申请日：2019-12-04

Applicant: SEQUENOM, INC.

Inventor： Charles R. Cantor

IPC: C12Q1/6837

Abstract: Described herein are products and processes for nucleic acid quantification, which are in part useful for detecting and determining the nucleotide sequence of rare nucleic acids (i.e., low copy number nucleic acids) in a sample. Such products and processes are useful for reducing the dynamic range among different nucleic acid species.

公开(公告)号：US10144966B2

公开(公告)日：2018-12-04

申请号：US14687790

申请日：2015-04-15

Applicant: SEQUENOM, INC.

Inventor： Charles R. Cantor

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6876 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6844

Abstract: Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that facilitates sequence analysis. The solid supports and methods provided herein minimize the number of steps required by published sequence analysis methodologies, and thereby offer improved sequence analysis efficiency.