公开(公告)号：US20100155668A1

公开(公告)日：2010-06-24

申请号：US12714284

申请日：2010-02-26

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： C09K11/02

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

公开(公告)号：US08080405B2

公开(公告)日：2011-12-20

申请号：US12406651

申请日：2009-03-18

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： C12M1/00 ,  C12Q1/68

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

公开(公告)号：US08071359B2

公开(公告)日：2011-12-06

申请号：US11566998

申请日：2006-12-05

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： C12M1/00 ,  C12Q1/68

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

公开(公告)号：US20090253211A1

公开(公告)日：2009-10-08

申请号：US12408466

申请日：2009-03-20

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： G01N33/50

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

公开(公告)号：US08639449B2

公开(公告)日：2014-01-28

申请号：US13097430

申请日：2011-04-29

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： G01N33/48 ,  G01N33/50

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。

公开(公告)号：US08071361B2

公开(公告)日：2011-12-06

申请号：US12714284

申请日：2010-02-26

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： C12M1/00 ,  C12Q1/68

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

公开(公告)号：US20060177945A1

公开(公告)日：2006-08-10

申请号：US11370656

申请日：2006-03-07

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： G01N33/551

CPC分类号： C12Q1/6816 ,  B82Y15/00 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  Y10T428/2982 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T436/24 ,  C12Q2563/107

摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) an affinity molecule linked to the semiconductor nanocrystal. The semiconductor nanocrystal is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Exposure of the semiconductor nanocrystal to excitation energy will excite the semiconductor nanocrystal causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.

摘要翻译： 描述能够连接到亲和分子的半导体纳米晶体化合物。 化合物包括（1）当被电磁辐射源或粒子束激发时能够发射电磁辐射和/或吸收能量和/或散射或衍射电磁辐射的半导体纳米晶体; 和（2）与半导体纳米晶体连接的亲和分子。 半导体纳米晶体与亲和分子连接以形成能够与可检测物质结合的半导体纳米晶体探针。 将半导体纳米晶体暴露于激发能将激发导致电磁辐射发射的半导体纳米晶体。 进一步描述的是分别制造发光半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并使用探针来确定材料中可检测物质的存在。

公开(公告)号：US08071360B2

公开(公告)日：2011-12-06

申请号：US12408466

申请日：2009-03-20

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： C12M1/00 ,  C12Q1/68

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。

公开(公告)号：US20110275169A1

公开(公告)日：2011-11-10

申请号：US13097430

申请日：2011-04-29

申请人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

发明人： Shimon Weiss ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： H01L21/66 ,  H01L21/20 ,  B82Y99/00

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。

公开(公告)号：US20090191567A1

公开(公告)日：2009-07-30

申请号：US12406651

申请日：2009-03-18

申请人： SHIMON WEISS ,  Marcel Bruchez ,  Paul Alivisatos

发明人： SHIMON WEISS ,  Marcel Bruchez ,  Paul Alivisatos

IPC分类号： C12Q1/68 ,  C09K11/08

CPC分类号： H01L33/0062 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  C09K11/89 ,  C09K11/892 ,  C12Q1/6816 ,  C12Q2563/107 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54373 ,  G01N33/588 ,  H01L33/0083 ,  Y10T436/141111 ,  Y10T436/142222

摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

摘要翻译： 描述了半导体纳米晶体化合物和探针。 该化合物能够连接至一个或多个亲和分子。 化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分 和能够连接到一个或多个亲和分子的第二部分。 一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供 第二节能量。 还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。