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    Methods and reagents for diagnosing rheumatoid arthrtis
    11.
    发明授权
    Methods and reagents for diagnosing rheumatoid arthrtis 有权
    用于诊断类风湿关节炎的方法和试剂

    公开(公告)号：US09528998B2

    公开(公告)日：2016-12-27

    申请号：US13086528

    申请日：2011-04-14

    申请人： Toru Yoshimura ,  Ryotaro Chiba

    发明人： Toru Yoshimura ,  Ryotaro Chiba

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6863 ,  G01N33/6803 ,  G01N33/6854 ,  G01N2800/102

    摘要： Methods for diagnosing rheumatoid arthritis (RA) are disclosed, using measurement of the CCL8 protein level in a test sample from a subject. Testing for CCL8 as an indicator of RA can be combined with testing for other indicators of RA, including clinical assessments, imaging or other RA markers such as Rheumatoid factor (RF). CCL8 testing can be used for discriminating RA from other diseases or conditions, evaluating the severity of RA. Related diagnostic reagents, kits, pharmaceutical compositions, and methods for identifying a candidate substance as a therapeutic agent for treating rheumatoid arthritis are also described.

    摘要翻译： 公开了用于诊断受试者的测试样品中CCL8蛋白质水平的方法来诊断类风湿性关节炎（RA）。 测试CCL8作为RA的指标可以与RA的其他指标的测试结合，包括临床评估，成像或其他RA标志物，如类风湿因子（RF）。 CCL8检测可用于区分RA与其他疾病或病症，评估RA的严重程度。 还描述了用于鉴定作为治疗类风湿性关节炎的治疗剂的候选物质的相关诊断试剂，试剂盒，药物组合物和方法。

    IMMUNOASSAY METHODS AND REAGENTS FOR DECREASING NONSPECIFIC BINDING
    12.
    发明申请
    IMMUNOASSAY METHODS AND REAGENTS FOR DECREASING NONSPECIFIC BINDING 审中-公开
    用于减少非特异性结合的免疫测定方法和试剂

    公开(公告)号：US20130130275A1

    公开(公告)日：2013-05-23

    申请号：US13472683

    申请日：2012-05-16

    申请人： Toru Yoshimura ,  Eisaku Yoshida ,  Ryotaro Chiba

    发明人： Toru Yoshimura ,  Eisaku Yoshida ,  Ryotaro Chiba

    IPC分类号： G01N33/86

    CPC分类号： G01N33/86

    摘要： Methods and kits for reducing non-specific binding in an immunoassay for PIVKA-II in a test sample are described, in which the test sample is reacted with an anti-prothrombin antibody in the presence of one or more of the following additives: skim milk, saponin, CaCl2, MgCl2, and a sulfobetaine zwitterionic detergent.

    摘要翻译： 描述了在测试样品中用于降低PIVKA-II的免疫测定中的非特异性结合的方法和试剂盒，其中所述测试样品在一种或多种以下添加剂存在下与抗凝血酶原抗体反应：脱脂乳 ，皂角苷，CaCl 2，MgCl 2和磺基甜菜碱两性离子洗涤剂。

    IMMUNOASSAY METHOD FOR PRO-GASTRIN-RELEASING PEPTIDE
    14.
    发明申请
    IMMUNOASSAY METHOD FOR PRO-GASTRIN-RELEASING PEPTIDE 审中-公开
    免疫抑制肽的免疫测定方法

    公开(公告)号：US20100136711A1

    公开(公告)日：2010-06-03

    申请号：US12518610

    申请日：2007-12-11

    申请人： Toru Yoshimura ,  Kenju Fujita ,  Barry L. Dowell

    发明人： Toru Yoshimura ,  Kenju Fujita ,  Barry L. Dowell

    IPC分类号： G01N33/53 ,  C07C317/02

    CPC分类号： G01N33/5306 ,  G01N33/57423 ,  G01N33/86 ,  G01N2333/5758

    摘要： To provide a more convenient and more accurate method of assaying ProGRP by improving the stability of ProGRP which is known to be unstable in a biological sample.By using a blood sample in a condition in which a blood coagulation factor is not activated is used as a sample, the degradation of ProGRP is suppressed, whereby it is possible to store a sample for a long period of time and to improve the accuracy of an assay.

    摘要翻译： 通过提高已知在生物样品中不稳定的ProGRP的稳定性来提供更方便和更准确的测定ProGRP的方法。 通过使用血液凝固因子未活化的状态下的血液样品作为样品，可以抑制ProGRP的降解，能够长时间存储样品，提高准确度 一个测定。

    HOMOCYSTEINE IMMUNOASSAY
    17.
    发明申请
    HOMOCYSTEINE IMMUNOASSAY 审中-公开
    免疫组织化学

    公开(公告)号：US20100022029A1

    公开(公告)日：2010-01-28

    申请号：US12575131

    申请日：2009-10-07

    申请人： Toru Yoshimura

    发明人： Toru Yoshimura

    IPC分类号： G01N33/566 ,  C07K16/00

    CPC分类号： G01N33/6815 ,  G01N33/5306

    摘要： In immunoassays such as homocysteine immunoassays, it is known that the measured values can be dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily and efficiently suppressed or eliminated, and also provides a kit used for such a method. The influence of the immunoreaction inhibiting substances is suppressed or eliminated when the analyte (e.g., homocysteine) contained in the biological sample is reacted with the antibody in the presence of extrinsic polyanion.

    摘要翻译： 在诸如同型半胱氨酸免疫测定的免疫测定中，已知由于存在于生物样品中的物质对免疫反应的影响，测量值可以分散。 本发明提供了容易且有效地抑制或消除免疫反应抑制物质的影响的方法，并且还提供了用于这种方法的试剂盒。 当外来聚阴离子存在下，当生物样品中包含的分析物（例如同型半胱氨酸）与抗体反应时，抑制或消除免疫反应抑制物质的影响。