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公开(公告)号：US20140134171A1
公开(公告)日：2014-05-15
申请号：US14056116
申请日：2013-10-17
Applicant: Tariq Ghayur , Junjian Liu , Sharmila Manoj , Susan E. Brophy
Inventor： Tariq Ghayur , Junjian Liu , Sharmila Manoj , Susan E. Brophy
CPC classification number: C07K16/468 , A61K45/06 , C07K16/00 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/515 , C07K2317/64 , C07K2317/732 , C07K2317/92
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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2.发明授权Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making 失效可溶性FMS样酪氨酸激酶-1（sFLT-1）抗体及相关组成，试剂盒，使用方法，材料及制备方法公开(公告)号：US08349325B2
公开(公告)日：2013-01-08
申请号：US12643847
申请日：2009-12-21
Applicant: Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner, legal representative , Zhiguang Yu
Inventor： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Zhiguang Yu
IPC: A61K39/395 , C07K16/18 , C07K16/28
CPC classification number: C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92
Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
Abstract translation: 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。
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公开(公告)号：US20130217145A1
公开(公告)日：2013-08-22
申请号：US13604967
申请日：2012-09-06
Applicant: Toru Yoshimura , Sharmila Manoj , Bailin Tu , Barry L. Dowell , Gangamani Beligere , Qiaoqiao Ruan , Anthony S. Muehoff
Inventor： Toru Yoshimura , Sharmila Manoj , Bailin Tu , Barry L. Dowell , Gangamani Beligere , Qiaoqiao Ruan , Anthony S. Muehoff
IPC: C07K16/18 , G01N33/566
CPC classification number: C07K16/18 , C07K16/40 , C07K2317/92 , G01N33/566 , G01N33/57438
Abstract: The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.
Abstract translation: 本发明涉及结合PIVKA II的抗体或结合蛋白，可用于例如肝细胞癌（HCC），肝癌和相关病症的诊断，治疗和预防。
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4.发明申请SOLUBLE FMS-LIKE TYROSINE KINASE-1 (sFLT-1) ANTIBODY AND RELATED COMPOSITION, KIT, METHODS OF USING, AND MATERIALS AND METHOD FOR MAKING 失效可溶性FMS-样酪氨酸激酶-1（sFLT-1）抗体及相关组合物，试剂盒，使用方法，材料和制备方法公开(公告)号：US20100266575A1
公开(公告)日：2010-10-21
申请号：US12643847
申请日：2009-12-21
Applicant: Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
Inventor： Susan E. Brophy , Saul A. Datwyler , David J. Hawksworth , Don C. Laird , Sharmila Manoj , Dominick L. Pucci , Bryan C. Tieman , Joan Tyner , Lowell J. Tyner , Zhiguang Yu
IPC: A61K39/395 , C07K16/40 , G01N33/573 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , A61P9/12
CPC classification number: C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/92
Abstract: An isolated antibody that specifically binds to sFlt-1 or a fragment thereof having (i) a variable heavy domain region comprising the amino acid sequence of SEQ ID NO: 2, (ii) a variable light domain region comprising the amino acid sequence of SEQ ID NO: 4, or (iii) both (i) and (ii), a pharmaceutical composition and a kit comprising such an antibody, a method of making such an antibody, a method of determining the presence, amount or concentration of sFlt-1 or a fragment thereof in a test sample, a method of treating a patient in therapeutic or prophylactic need of an antagonist of sFlt-1, an isolated nucleic acid comprising a nucleotide sequence encoding the amino acid sequence of (i) SEQ ID NO: 2, (ii) SEQ ID NO: 4, or (iii) both (i) and (ii), optionally as part of a vector, and a host cell comprising and expressing such a nucleic acid.
Abstract translation: 特异性结合sFlt-1或其片段的分离的抗体，其具有（i）包含SEQ ID NO：2的氨基酸序列的可变重结构域，（ii）包含SEQ ID NO：2的氨基酸序列的可变轻区域区域 SEQ ID NO：4，或（iii）（i）和（ii）两者，药物组合物和包含这种抗体的试剂盒，制备这种抗体的方法，确定sFlt- 1或其片段，治疗或预防性地需要sFlt-1拮抗剂的方法，分离的核酸，其包含编码（i）SEQ ID NO：1的氨基酸序列的核苷酸序列， 2，（ii）SEQ ID NO：4或（iii）（i）和（ii），任选地作为载体的一部分，以及包含并表达这种核酸的宿主细胞。
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公开(公告)号：US08586714B2
公开(公告)日：2013-11-19
申请号：US12873926
申请日：2010-09-01
Applicant: Tariq Ghayur , Junjian Liu , Sharmila Manoj , Susan E. Brophy
Inventor： Tariq Ghayur , Junjian Liu , Sharmila Manoj , Susan E. Brophy
IPC: C07K16/46 , C07K16/28 , C07K16/44 , C07K16/00 , A61K39/395
CPC classification number: C07K16/468 , A61K45/06 , C07K16/00 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/515 , C07K2317/64 , C07K2317/732 , C07K2317/92
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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Patent Agency Ranking
公开(公告)号：US08741287B2
公开(公告)日：2014-06-03
申请号：US12485114
申请日：2009-06-16
Applicant: Susan E. Brophy , Lianli Chi , Saul A Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Zhiguang Yu , Robert N. Ziemann , Lowell J. Tyner
Inventor： Susan E. Brophy , Lianli Chi , Saul A Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Zhiguang Yu , Robert N. Ziemann
IPC: A61K39/395 , C12Q3/00 , G01N33/53
CPC classification number: C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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公开(公告)号：US20140024050A1
公开(公告)日：2014-01-23
申请号：US13767457
申请日：2013-02-14
Applicant: TORU YOSHIMURA , Sharmila Manoj , Bailin Tu , Anthony S. Muerhoff
Inventor： TORU YOSHIMURA , Sharmila Manoj , Bailin Tu , Anthony S. Muerhoff
IPC: C07K16/18 , G01N33/574
CPC classification number: C07K16/18 , C07K16/303 , C07K16/40 , C07K2317/34 , C07K2317/92 , G01N33/57438 , G01N33/57488
Abstract: The present invention relates to antibodies or binding proteins which bind to PIVKA II and may be used, for example, in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.
Abstract translation: 本发明涉及结合PIVKA II的抗体或结合蛋白，可用于例如肝细胞癌（HCC），肝癌和相关病症的诊断，治疗和预防。
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公开(公告)号：US20060051368A1
公开(公告)日：2006-03-09
申请号：US11187652
申请日：2005-07-22
Applicant: Patricia Spear , Sharmila Manoj , Cheryl Jogger , Dawn Myscofski , Miri Yoon
Inventor： Patricia Spear , Sharmila Manoj , Cheryl Jogger , Dawn Myscofski , Miri Yoon
IPC: A61K39/12 , C07H21/04 , C07K14/035 , C12N15/86
CPC classification number: C07K14/005 , A61K2039/525 , C12N2710/16622
Abstract: The present invention relates to compositions and methods related to mutant herpes simplex virus nucleic acid and proteins that find use in analyzing, diagnosing, and regulating viral infection.
Abstract translation: 本发明涉及可用于分析，诊断和调节病毒感染的突变单纯疱疹病毒核酸和蛋白质相关的组合物和方法。
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公开(公告)号：US20110091372A1
公开(公告)日：2011-04-21
申请号：US12873926
申请日：2010-09-01
Applicant: Tariq Ghayur , Junjian Liu , Sharmila Manoj , Susan E. Brophy
Inventor： Tariq Ghayur , Junjian Liu , Sharmila Manoj , Susan E. Brophy
IPC: A61K51/00 , C07K16/00 , C12N9/96 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , C12N1/11 , C12N1/15 , C12N1/19 , C12P21/00 , A61K39/395 , A61P19/02 , A61P35/00 , A61P25/28 , A61P9/10 , A61P31/12 , A61P5/50 , A61P37/06 , A61P17/06
CPC classification number: C07K16/468 , A61K45/06 , C07K16/00 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/515 , C07K2317/64 , C07K2317/732 , C07K2317/92
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20100015637A1
公开(公告)日：2010-01-21
申请号：US12485114
申请日：2009-06-16
Applicant: Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
Inventor： Susan E. Brophy , Lianli Chi , Saul A. Datwyler , David J. Hawksworth , Don M. Laird , Sharmila Manoj , Mary S. Pinkus , Dominick L. Pucci , Carol S. Ramsay , David C. Sogin , Bailin Tu , Joan D. Tyner , Lowell J Tyner , Zhiguang Yu , Robert N. Ziemann
CPC classification number: C07K16/22 , C07K14/475 , C07K2317/92 , G01N33/74 , G01N2333/475
Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.
Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。
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