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    Zinc-containing sustained-release composition, its preparation, and method for producing the same
    11.
    发明申请
    Zinc-containing sustained-release composition, its preparation, and method for producing the same 失效
    含锌缓释组合物及其制备方法及其制备方法

    公开(公告)号：US20060210629A1

    公开(公告)日：2006-09-21

    申请号：US10555191

    申请日：2004-04-01

    申请人： Michio Kimura ,  Tomoko Eto ,  Yutaka Mizushima

    发明人： Michio Kimura ,  Tomoko Eto ,  Yutaka Mizushima

    IPC分类号： A61K39/395 ,  A61K38/21 ,  A61K38/19 ,  A61K38/18 ,  A61K9/22 ,  A61K33/32

    CPC分类号： C07K16/241 ,  A61K9/0019 ,  A61K9/10 ,  A61K33/30 ,  A61K38/193 ,  A61K38/212 ,  A61K38/27 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

    摘要： With a simple and high-yield production method, a zinc-containing sustained-release composition capable of stabilizing a physiologically active protein or peptide, typically G-CSF by precipitation and retaining drug efficacy for several days in a living body owing to its sustained releasability is provided. Concretely, a zinc-containing sustained-release composition produced by forming a precipitate by mixing a physiologically active protein or peptide, a water-soluble zinc salt, a water-soluble carbonate and/or a water soluble phosphate aqueous solution. The zinc-containing sustained-release composition may be administered as a zinc-containing sustained preparation by adding a pharmaceutically acceptable additive as is necessary.

    摘要翻译： 通过简单且高产量的生产方法，能够通过沉淀稳定生理活性蛋白质或肽，通常为G-CSF的锌含量缓释组合物，由于其具有持续的释放性，在活体中保持药物疗效几天 被提供。 具体地说，通过混合生理活性蛋白质或肽，水溶性锌盐，水溶性碳酸盐和/或水溶性磷酸盐水溶液形成沉淀物而制备的含锌缓释组合物。 含锌持续释放组合物可以通过根据需要添加药学上可接受的添加剂作为含锌缓释制剂施用。

    Process for preparing halogenated benzene derivatives
    12.
    发明授权
    Process for preparing halogenated benzene derivatives 失效
    卤代苯衍生物的制备方法

    公开(公告)号：US4962245A

    公开(公告)日：1990-10-09

    申请号：US313074

    申请日：1989-02-21

    申请人： Takashi Kanai ,  Michio Kimura ,  Yoshio Noguchi

    发明人： Takashi Kanai ,  Michio Kimura ,  Yoshio Noguchi

    IPC分类号： C07C17/38 ,  C07C17/389 ,  C07C25/02

    CPC分类号： C07C25/02 ,  C07C17/38 ,  C07C17/389

    摘要： By a process for preparing halogenated benzene derivatives comprising distilling or stripping a mixture of the isomers of a halogenated benzene derivative containing a hydrogen halide to remove the hydrogen halide from the isomeric mixture of the halogenated benzene derivative and then contacting with a zeolite adsorbent for selectivity separating the desired isomer of the halogenated benzene derivative, it is possible to prevent from degrading the zeolite adsorbent. And it is possible to separate selectively industrially an desired isomer of the halogenated benzene derivative for a long time without reduction of productivity and to separate selectively the desired isomer in high purity.

    Image forming apparatus
    13.
    发明授权
    Image forming apparatus 有权
    图像形成装置

    公开(公告)号：US08798487B2

    公开(公告)日：2014-08-05

    申请号：US13348062

    申请日：2012-01-11

    申请人： Tomoharu Asano ,  Takaaki Ikegami ,  Michio Kimura

    发明人： Tomoharu Asano ,  Takaaki Ikegami ,  Michio Kimura

    IPC分类号： G03G15/00

    CPC分类号： G03G15/5037 ,  G03G15/553 ,  G03G21/1671

    摘要： An image forming apparatus having an image bearing member, a charger to charge the surface of the image bearing member, an irradiator to irradiate the image bearing member to form the latent image, a developing device to develop the latent electrostatic image with toner to obtain a visible image, a transfer device to transfer the visible image to a transfer medium by a transfer bias applied to a transfer area between the image bearing member and the transfer member, and a voltage detector to measure a first surface voltage and a second surface voltage under different conditions, and a life expectancy identification device to identify whether or when the expected working life of the image bearing member has come to the end based on a comparison of the first surface voltage and the second surface voltage.

    摘要翻译： 一种具有图像承载部件的图像形成装置，对图像承载部件的表面充电的充电器，用于照射图像承载部件以形成潜像的照射器，用调色剂显影静电潜像的显影装置， 可见图像，通过施加到图像承载部件和转印部件之间的转印区域的转印偏压将可见图像转印到转印介质的转印装置，以及电压检测器，用于测量第一表面电压和第二表面电压 不同的条件，以及预期寿命识别装置，用于基于第一表面电压和第二表面电压的比较来确定图像承载部件的预期使用寿命是否或何时已经到了最后。

    Protein having an affinity for a heparin-binding growth factor
    18.
    发明授权
    Protein having an affinity for a heparin-binding growth factor 失效
    对肝素结合生长因子具有亲和力的蛋白质

    公开(公告)号：US5650495A

    公开(公告)日：1997-07-22

    申请号：US549752

    申请日：1996-03-05

    申请人： Michio Kimura ,  Kazuyuki Doi

    发明人： Michio Kimura ,  Kazuyuki Doi

    IPC分类号： A61K38/22 ,  A61P25/00 ,  A61P43/00 ,  C07K1/20 ,  C07K1/22 ,  C07K14/47 ,  C07K14/475 ,  C07K14/51

    CPC分类号： C07K14/475 ,  C07K14/4702 ,  Y10S930/12

    摘要： An isolated protein having the amino terminal sequence of SEQ ID No. 1 and having a molecular weight of about 200 KDa is described. This animal brain-derived protein binds to OSF-1 (HBGF-8), which is a heparin-binding growth factor that has neuronal differentiation-enhancing activity, and a proliferative action on osteoblasts.

    摘要翻译： PCT No.PCT / JP94 / 00832 Sec。 371日期：1996年3月5日 102（e）1996年3月5日PCT PCT 1994年5月25日PCT公布。 公开号WO94 / 28022 日期1994年12月8日描述了具有SEQ ID No.1的氨基末端序列并具有约200KDa分子量的分离的蛋白质。 这种动物脑源性蛋白与OSF-1（HBGF-8）结合，其是具有神经元分化增强活性的肝素结合生长因子和对成骨细胞的增殖作用。

    System and method for securely affixing an element to a structure
    20.
    发明授权
    System and method for securely affixing an element to a structure 失效
    用于将元件牢固地固定到结构体的系统和方法

    公开(公告)号：US4894269A

    公开(公告)日：1990-01-16

    申请号：US127811

    申请日：1987-12-03

    申请人： Michio Kimura

    发明人： Michio Kimura

    IPC分类号： E04B1/41 ,  F16B13/14

    CPC分类号： E04B1/41 ,  F16B13/143 ,  Y10T428/15 ,  Y10T428/249997

    摘要： A system for securely offixing to a structure at a recess therein comprises a container body filled with a main component and sealed with a cap formed in part by solidifying a hardening agent and an inorganic material with a solidifying agent. The cap may be formed by confining a hardening agent in a film or coated film of plastics. The container body is further subjected to flaw or strain working or otherwise formed to be weakened so as to break into small pieces when subjected to a force by the element. The main component and the hardening agent then react, within the recess, to securely affix the element to the structure. In another aspect of the invention, a method is provided for retaining the first component in its frangible container with a cap comprising the reactive or hardening agent for placement in a recess of the structure for forcible breakage of the container, a reaction and secure affixation by the reaction product.

    摘要翻译： 用于在其凹部处牢固地混合到结构体的系统包括填充有主要部件的容器主体，并且通过用固化剂固化硬化剂和无机材料部分地形成的帽密封。 帽可以通过将硬化剂限制在塑料的膜或涂膜中而形成。 容器主体进一步经受缺陷或应变加工或以其它方式形成为被削弱，以便当受到元件的力的影响时，该容器本体将被破碎成小块。 主要部件和硬化剂然后在凹槽内反应以将元件牢固地固定到结构上。 在本发明的另一方面，提供了一种用于将第一组分保持在其易碎容器中的方法，其具有包含反应性或硬化剂的帽，用于放置在结构的凹部中用于强制破坏容器，反应和固定的固定 反应产物。