公开(公告)号：US07183765B2

公开(公告)日：2007-02-27

申请号：US10879222

申请日：2004-06-28

申请人： Michael McElfresh ,  Matthew Lucas ,  Joseph P. Silveira ,  Scott E. Groves

发明人： Michael McElfresh ,  Matthew Lucas ,  Joseph P. Silveira ,  Scott E. Groves

IPC分类号： G01R33/032 ,  G01B7/14

CPC分类号： G01D5/145 ,  G01D5/266 ,  G01D5/35303

摘要： A micro-position sensor and sensing system using the Faraday Effect. The sensor uses a permanent magnet to provide a magnetic field, and a magneto-optic material positioned in the magnetic field for rotating the plane of polarization of polarized light transmitted through the magneto-optic material. The magnet is independently movable relative to the magneto-optic material so as to rotate the plane of polarization of the polarized light as a function of the relative position of the magnet. In this manner, the position of the magnet relative to the magneto-optic material may be determined from the rotated polarized light. The sensing system also includes a light source, such as a laser or LED, for producing polarized light, and an optical fiber which is connected to the light source and to the magneto-optic material at a sensing end of the optical fiber. Processing electronics, such as a polarimeter, are also provided for determining the Faraday rotation of the plane of polarization of the back-reflected polarized light to determine the position of the magnet relative to the sensing end of the optical fiber.

摘要翻译： 使用法拉第效应的微位置传感器和感测系统。 传感器使用永久磁铁提供磁场，以及位于磁场中的磁光材料，用于旋转透过磁光材料的偏振光的偏振平面。 磁体可相对于磁光材料独立地移动，以便作为磁体的相对位置的函数旋转偏振光的偏振平面。 以这种方式，可以从旋转的偏振光确定磁体相对于磁光材料的位置。 感测系统还包括用于产生偏振光的光源，例如激光器或LED，以及在光纤的感测端连接到光源和磁光材料的光纤。 还提供诸如旋光仪的处理电子设备，用于确定背反射偏振光的偏振平面的法拉第旋转，以确定磁体相对于光纤的感测端的位置。

公开(公告)号：US20060117022A1

公开(公告)日：2006-06-01

申请号：US11260794

申请日：2005-10-27

申请人： Matthew Lucas

发明人： Matthew Lucas

IPC分类号： G06F17/30

CPC分类号： G06F16/2358

摘要： A communication method comprises generating a notification that includes a content portion and a notification availability indicator; transmitting the notification from a server to a client; and receiving the notification at the client. In one embodiment, the notification availability indicator includes a time value, indicating the likely time before another notification will be transmitted.

摘要翻译： 通信方法包括生成包括内容部分和通知可用性指示符的通知; 将所述通知从服务器发送到客户端; 并在客户端收到通知。 在一个实施例中，通知可用性指示符包括指示在另一通知被发送之前的可能时间的时间值。

公开(公告)号：US20110296413A1

公开(公告)日：2011-12-01

申请号：US13116657

申请日：2011-05-26

申请人： Stephen Wood ,  Samuel William Bailey ,  Matthew Lucas

发明人： Stephen Wood ,  Samuel William Bailey ,  Matthew Lucas

IPC分类号： G06F9/455 ,  G06F17/30

CPC分类号： G06F9/45533 ,  G06F8/656 ,  G06F9/45504 ,  G06F9/45508 ,  G06F9/45558 ,  G06F17/30073 ,  G06F17/30528 ,  G06F2009/45575 ,  G06F2009/45583 ,  H04L63/102 ,  H04L63/104

摘要： Techniques and systems for modifying a virtual machine functionality. Archive files each including at least a class files are received. The archive files are stored within the virtual machine. The virtual machine runs on a host system and neither the virtual machine nor the host system are restarted in response to the receiving or storing of the archive files. Files of the host system are scanned to find class files that are not included in a class path for the virtual machine. The class files are copied to a class path for the virtual machine. Neither the virtual machine nor the host system are restarted in response to the copying of the class files. The classes corresponding to the class files are registered in the virtual machine in response to the copying of the class files to the class path. Neither the virtual machine nor the host system are restarted in response to the registration of the classes.

摘要翻译： 用于修改虚拟机功能的技术和系统。 接收至少包含类文件的归档文件。 归档文件存储在虚拟机中。 虚拟机在主机系统上运行，并且虚拟机和主机系统都不会重新启动，以响应接收或存储归档文件。 扫描主机系统的文件以查找不包含在虚拟机的类路径中的类文件。 类文件被复制到虚拟机的类路径。 响应于类文件的复制，虚拟机和主机系统都不重新启动。 响应于将类文件复制到类路径，对应于类文件的类被注册在虚拟机中。 响应于类的注册，虚拟机和主机系统都不重新启动。

公开(公告)号：US20100305096A1

公开(公告)日：2010-12-02

申请号：US12787613

申请日：2010-05-26

申请人： Georgette Castanedo ,  Bryan Chan ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

发明人： Georgette Castanedo ,  Bryan Chan ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

IPC分类号： A61K31/5377 ,  C07D495/04 ,  C07D471/04 ,  C07D473/16 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61P35/00 ,  A61P37/00 ,  A61P9/00 ,  A61P31/12 ,  A61P29/00 ,  A61P3/00 ,  A61P5/00 ,  A61P25/00

CPC分类号： C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式（I）和（Ib）化合物，其中（i）X1为N，X 2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，或（iv）X1为CR7， X 2为O，包括立体异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗由脂质激酶如炎症，免疫学和癌症介导的病症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20100305084A1

公开(公告)日：2010-12-02

申请号：US12787608

申请日：2010-05-26

申请人： Georgette Castanedo ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

发明人： Georgette Castanedo ,  David Goldstein ,  Rama Kondru ,  Matthew Lucas ,  Wylie Palmer ,  Stephen Price ,  Brian Safina ,  Pascal Pierre Alexandre Savy ,  Eileen Mary Seward ,  Daniel P. Sutherlin ,  Zachary K. Sweeney

IPC分类号： A61K31/5377 ,  C07D513/04 ,  C07D498/10 ,  A61K31/5386 ,  A61K31/555 ,  A61P37/00 ,  A61P35/00 ,  A61P9/00 ,  A61P31/12 ,  A61P29/00 ,  A61P3/00 ,  A61P5/00 ,  A61P25/00

CPC分类号： C07D495/04 ,  C07D487/04 ,  C07D513/04

摘要： Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, (iv) X1 is CR7 and X2 is O, or (v) X1 is CR7 and X2 is NR2, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

摘要翻译： 式（I）和（Ib）化合物，其中（i）X1为N，X2为S，（ii）X1为CR7，X2为S，（iii）X1为N，X2为NR2，（iv）X1为CR7和X2 是O，或（v）X1是CR7，X2是NR2，包括立体异构体，互变异构体，代谢物和药学上可接受的盐可用于抑制PI3K的δ同种型，以及用于治疗脂质激酶介导的疾病，例如炎症，免疫学 ，和癌症。 公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：US20050029436A1

公开(公告)日：2005-02-10

申请号：US10879222

申请日：2004-06-28

申请人： Michael McElfresh ,  Matthew Lucas ,  Joseph Silveira

发明人： Michael McElfresh ,  Matthew Lucas ,  Joseph Silveira

IPC分类号： G01D5/14 ,  G01D5/26 ,  G01D5/353 ,  G02F1/01

CPC分类号： G01D5/145 ,  G01D5/266 ,  G01D5/35303

摘要： A micro-position sensor and sensing system using the Faraday Effect. The sensor uses a permanent magnet to provide a magnetic field, and a magneto-optic material positioned in the magnetic field for rotating the plane of polarization of polarized light transmitted through the magneto-optic material. The magnet is independently movable relative to the magneto-optic material so as to rotate the plane of polarization of the polarized light as a function of the relative position of the magnet. In this manner, the position of the magnet relative to the magneto-optic material may be determined from the rotated polarized light. The sensing system also includes a light source, such as a laser or LED, for producing polarized light, and an optical fiber which is connected to the light source and to the magneto-optic material at a sensing end of the optical fiber. Processing electronics, such as a polarimeter, are also provided for determining the Faraday rotation of the plane of polarization of the back-reflected polarized light to determine the position of the magnet relative to the sensing end of the optical fiber.

摘要翻译： 使用法拉第效应的微位置传感器和感测系统。 传感器使用永久磁铁提供磁场，以及位于磁场中的磁光材料，用于旋转透过磁光材料的偏振光的偏振平面。 磁体可相对于磁光材料独立地移动，以便作为磁体的相对位置的函数旋转偏振光的偏振平面。 以这种方式，可以从旋转的偏振光确定磁体相对于磁光材料的位置。 感测系统还包括用于产生偏振光的光源，例如激光器或LED，以及在光纤的感测端连接到光源和磁光材料的光纤。 还提供诸如旋光仪的处理电子设备，用于确定背反射偏振光的偏振平面的法拉第旋转，以确定磁体相对于光纤的感测端的位置。