公开(公告)号：US5902578A

公开(公告)日：1999-05-11

申请号：US621384

申请日：1996-03-25

申请人： Margaret Ione Halpin-Dohnalek ,  Milo Duane Hilty ,  Douglas Gene Bynum

发明人： Margaret Ione Halpin-Dohnalek ,  Milo Duane Hilty ,  Douglas Gene Bynum

IPC分类号： A23L29/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  C12N1/20

CPC分类号： A61K35/747 ,  A23L29/065 ,  A61K35/745

摘要： A novel method for the prevention of infectious diarrhea or diarrhea caused by antibiotic therapy is disclosed. The method comprises the steps of 1) mixing a powder comprising viable cultures of the probiotic organisms Lactobacillus reuteri, Lactobacillus acidophilus and Bifidobacieriurn infantis with a liquid; and 2) enterally administering the mixture to a mammal or a human. In a preferred embodiment at least 10.sup.6 CFU (colony forming units) of each probiotic organism is consumed per day. The invention also relates to pills or capsules containing the probiotic system (Lactobacillus reuteri, Lactobacillus acidophilus and Bifidobacterium infantis) in a freeze dried or lyophilized form. The invention also relates to a novel powdered nutritional formula for the prevention of diarrhea that comprises protein, fat, carbohydrates and the microorganisms Lactobacillus reuteri, Lactobacillus acidophilis and Bifidobacterium infantis. In a preferred embodiment the powdered nutritional formula is a nutritionally complete infant formula. A large clinical study has shown that the probiotic system according to the invention when provided in a non-fermented form is efficacious in the prevention of diarrhea. Also disclosed is a method for manufacturing the formula of the invention.

摘要翻译： 公开了一种预防由抗生素治疗引起的感染性腹泻或腹泻的新方法。 该方法包括以下步骤：1）将含有益生菌乳酸乳杆菌，嗜酸乳酸杆菌和双歧杆菌的生物培养物与液体混合; 和2）将所述混合物肠内施用于哺乳动物或人。 在优选的实施方案中，每天每消耗益生菌生物体的至少106CFU（集落形成单位）。 本发明还涉及以冷冻干燥或冻干形式含有益生菌体系（嗜酸乳杆菌，嗜酸乳杆菌和婴儿双歧杆菌）的丸剂或胶囊。 本发明还涉及一种用于预防腹泻的新型粉状营养配方，其包含蛋白质，脂肪，碳水化合物和微生物乳酸乳杆菌，嗜酸乳杆菌和婴儿双歧杆菌。 在优选的实施方案中，粉状营养配方是营养完全的婴儿配方食品。 大量的临床研究表明，当以非发酵形式提供时，根据本发明的益生菌系统在预防腹泻方面是有效的。 还公开了制造本发明的配方的方法。

公开(公告)号：US5827526A

公开(公告)日：1998-10-27

申请号：US653084

申请日：1996-06-12

申请人： Margaret Ione Halpin Dohnalek ,  Karin Margaret Ostrom ,  Milo Duane Hilty

发明人： Margaret Ione Halpin Dohnalek ,  Karin Margaret Ostrom ,  Milo Duane Hilty

IPC分类号： A61K31/702 ,  A23C9/13 ,  A23G3/34 ,  A23L2/52 ,  A23L29/244 ,  A61K31/715 ,  A61K31/733 ,  A61P1/12 ,  A61K9/68

CPC分类号： A61K31/715 ,  A23C9/1307 ,  A23G3/346 ,  A23L2/52 ,  A23L29/244 ,  A61K31/702 ,  A61K31/733 ,  A23G2200/06 ,  Y10S514/867

摘要： A method is provided for reducing the duration of diarrhea and recurrent episodes of diarrhea in humans by enterally administering indigestible oligosaccharides prophylactically. More specifically, the present invention relates to a method using indigestible oligosaccharides or fructooligosaccharides (FOS) to reduce the duration and recurrence of diarrhea in a human wherein between 0.5 grams and 5 grams of at least one FOS selected from the group consisting of 1-kestose, nystose, and 1.sup.F -.beta.-fructofuranosyl nystose is administered to said human per day. The indigestible oligosaccharides can be produced through enzymatic synthesis, chemical techniques or isolated from plant materials and are administered in the form of a nutritional product, candy, tablets, chewing gum, lozenges, milk, yogurts, fermented products and the like.

摘要翻译： 提供一种通过预防肠内施用难消化的寡糖来减少人体腹泻和腹泻复发的持续时间的方法。 更具体地，本发明涉及使用难消化的寡糖或低聚果糖（FOS）来减少人的腹泻持续时间和复发的方法，其中0.5克和5克之间的至少一种FOS选自1-睾丸 ，蔗糖，和1F-β-呋喃果糖基蔗糖，每天给予所述人。 不可消化的寡糖可以通过酶合成，化学技术或从植物材料中分离而产生，并以营养产品，糖果，片剂，口香糖，锭剂，牛奶，酸奶，发酵产品等的形式施用。