公开(公告)号：US20150191486A1

公开(公告)日：2015-07-09

申请号：US14665237

申请日：2015-03-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takanobu KUROITA ,  Yasuhiro IMAEDA ,  Kouichi IWANAGA ,  Naohiro TAYA ,  Hidekazu TOKUHARA ,  YOSHIYUKI FUKASE

IPC: C07D495/04 ,  C07D487/08 ,  C07D405/14 ,  C07D401/12 ,  C07D471/04

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D401/14 ,  C07D405/14 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D495/04

Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

Abstract translation: 由式表示的化合物，其中各符号如说明书中所定义，其前药具有优异的肾素抑制活性，可用作预防或治疗高血压，高血压等各种器官损害的药剂。

公开(公告)号：US20200270243A1

公开(公告)日：2020-08-27

申请号：US16753613

申请日：2018-10-04

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinji NAKAMURA ,  Satoshi MIKAMI ,  Tomoaki HASUI ,  Tohru YAMASHITA ,  Shinji MORIMOTO ,  Hidekazu TOKUHARA ,  Norio OYABU ,  Masami YAMADA ,  Atsuko OCHIDA ,  Kazuaki TAKAMI ,  Xin LIU

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04 ,  A61K9/20

Abstract: The present invention aims to provide a heterocyclic compound having an AMPA receptor potentiator effect, which is expected to be useful as an agent for the prophylaxis or treatment of depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like.The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20170144973A1

公开(公告)日：2017-05-25

申请号：US15321609

申请日：2015-06-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26 ,  C07D491/056 ,  C07D491/048 ,  C07F7/08 ,  C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20160176873A1

公开(公告)日：2016-06-23

申请号：US15055156

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D471/04

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.

公开(公告)号：US20160176822A1

公开(公告)日：2016-06-23

申请号：US15055197

申请日：2016-02-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Mitsunori KONO ,  Atsuko OCHIDA ,  Takashi IMADA ,  Hidekazu TOKUHARA ,  Yoshihide TOMATA ,  Naoki ISHII ,  Michiko TAWADA ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC: C07D217/26

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: The present invention provides a heterocyclic compound having a RORγt inhibitory action.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.