公开(公告)号：US09346776B2

公开(公告)日：2016-05-24

申请号：US14619489

申请日：2015-02-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zenichi Ikeda ,  Minoru Sasaki ,  Keiko Kakegawa ,  Fumiaki Kikuchi ,  Yoichi Nishikawa

IPC: C07D307/81

CPC classification number: C07D307/81

Abstract: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

Abstract translation: 提供具有肠肽酶抑制作用的稠合杂环化合物和该化合物作为治疗或预防肥胖症，糖尿病等的药物的用途。 具体地，提供由下式（I）表示的化合物：其中每个符号如本文所定义，或其盐，并且使用该化合物作为治疗或预防肥胖，糖尿病等的药物。

公开(公告)号：US20150152052A1

公开(公告)日：2015-06-04

申请号：US14389004

申请日：2013-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Minoru Sasaki ,  Hideki Furukawa ,  Kousuke Hidaka ,  Kyoko Toyofuku ,  Takatoshi Yogo ,  Toshiki Murata

IPC: C07D211/60 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04 ,  C07D401/12 ,  C07D401/06

CPC classification number: C07D211/60 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04

Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。

公开(公告)号：US20150225354A1

公开(公告)日：2015-08-13

申请号：US14619464

申请日：2015-02-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Zenichi Ikeda ,  Minoru Sasaki ,  Keiko Kakegawa ,  Fumiaki Kikuchi ,  Yoichi Nishikawa

IPC: C07D261/04 ,  C07D413/10

CPC classification number: C07D261/04 ,  C07D413/10

Abstract: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

Abstract translation: 提供具有肠肽酶抑制作用的稠合杂环化合物和该化合物作为治疗或预防肥胖症，糖尿病等的药物的用途。 具体地，提供由下式（I）表示的化合物：其中每个符号如本文所定义，或其盐，并且使用该化合物作为治疗或预防肥胖，糖尿病等的药物。