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公开(公告)号：US09073864B2
公开(公告)日：2015-07-07
申请号：US14389004
申请日：2013-03-28
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Minoru Sasaki , Hideki Furukawa , Kousuke Hidaka , Kyoko Toyofuku , Takatoshi Yogo , Toshiki Murata
IPC: C07D211/06 , A61K31/445 , C07D211/60 , C07D401/12 , C07D401/06 , C07D413/12 , C07D498/04 , C07D405/14
CPC classification number: C07D211/60 , C07D401/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D498/04
Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.
Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。
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公开(公告)号：US20140243310A1
公开(公告)日：2014-08-28
申请号：US14353622
申请日：2012-10-23
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC: C07D231/56 , C07D498/04 , C07D307/80 , C07D413/04 , C07D263/57 , C07D235/18
CPC classification number: C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US09133129B2
公开(公告)日：2015-09-15
申请号：US14353622
申请日：2012-10-23
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC: A61K31/437 , C07D471/04 , C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/4439 , C07D413/04 , C07D498/04 , C07D307/80 , C07D235/18 , C07D263/57 , C07D513/04
CPC classification number: C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US20150152052A1
公开(公告)日：2015-06-04
申请号：US14389004
申请日：2013-03-28
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Minoru Sasaki , Hideki Furukawa , Kousuke Hidaka , Kyoko Toyofuku , Takatoshi Yogo , Toshiki Murata
IPC: C07D211/60 , C07D405/14 , C07D413/12 , C07D498/04 , C07D401/12 , C07D401/06
CPC classification number: C07D211/60 , C07D401/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D498/04
Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.
Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。
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