公开(公告)号：US20150152052A1

公开(公告)日：2015-06-04

申请号：US14389004

申请日：2013-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Minoru Sasaki ,  Hideki Furukawa ,  Kousuke Hidaka ,  Kyoko Toyofuku ,  Takatoshi Yogo ,  Toshiki Murata

IPC: C07D211/60 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04 ,  C07D401/12 ,  C07D401/06

CPC classification number: C07D211/60 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04

Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。

公开(公告)号：US09073864B2

公开(公告)日：2015-07-07

申请号：US14389004

申请日：2013-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Minoru Sasaki ,  Hideki Furukawa ,  Kousuke Hidaka ,  Kyoko Toyofuku ,  Takatoshi Yogo ,  Toshiki Murata

IPC: C07D211/06 ,  A61K31/445 ,  C07D211/60 ,  C07D401/12 ,  C07D401/06 ,  C07D413/12 ,  C07D498/04 ,  C07D405/14

CPC classification number: C07D211/60 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04

Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。