公开(公告)号：US10787462B2

公开(公告)日：2020-09-29

申请号：US15769201

申请日：2016-10-21

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Takatoshi Yogo ,  Masato Yoshikawa ,  Morihisa Saitoh ,  Taisuke Katoh ,  Tomohiro Seki ,  Yoshihisa Nakada

IPC: C07D519/00 ,  C07D487/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61P31/12 ,  A61P13/12 ,  A61P1/16 ,  A61P25/00

Abstract: The present invention provides a heterocyclic compound having an RIP1 kinase inhibitory action, which is useful for the prophylaxis or treatment of Gaucher's disease, Niemann-Pick disease, inflammatory bowel disease, multiple sclerosis, chronic kidney disease, acute kidney injury, acute hepatic failure, autoimmune hepatitis, hepatitis B, hepatitis C, alcohol steatohepatitis, non-alcohol steatohepatitis and the like.The present invention relates to a compound represented by the following formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09073864B2

公开(公告)日：2015-07-07

申请号：US14389004

申请日：2013-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Minoru Sasaki ,  Hideki Furukawa ,  Kousuke Hidaka ,  Kyoko Toyofuku ,  Takatoshi Yogo ,  Toshiki Murata

IPC: C07D211/06 ,  A61K31/445 ,  C07D211/60 ,  C07D401/12 ,  C07D401/06 ,  C07D413/12 ,  C07D498/04 ,  C07D405/14

CPC classification number: C07D211/60 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04

Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。