公开(公告)号：US20190277811A1

公开(公告)日：2019-09-12

申请号：US16334214

申请日：2017-09-19

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  OAKLAND UNIVERSITY

发明人： Xudong FAN ,  Zhizheng ZHANG ,  Xiangqun ZENG

IPC分类号： G01N29/44 ,  G01N29/02 ,  G01N21/45 ,  G01N29/036 ,  G01N29/22 ,  G01N21/552

摘要： A multi-modal biosensor system includes a vibrating plate orientated along a plane. An actuator is interfaced with the vibrating plate and operable to vibrate the vibrating plate along the plane. The actuator includes two electrodes rigidly affixed to the vibrating plate. An optical support structure is rigidly affixed to the vibrating plate, and provides an outwardly facing surface to receive a measurement sample. A light source is configured to project light onto the outwardly facing surface of the optical support structure. A light detector is configured to capture light reflected from the outwardly facing surface of the optical support structure. A controller interfaces with the two electrodes and the light detector. The controller operates to detect changes in the vibrating motion of the vibrating plate concurrently with detecting changes in the light captured by the light detector.

公开(公告)号：US20160290955A1

公开(公告)日：2016-10-06

申请号：US15037809

申请日：2014-12-04

申请人： The Regents of The University of Michigan

发明人： Zhaohui ZHONG ,  Girish KULKARNI ,  Karthik REDDY ,  Xudong FAN

IPC分类号： G01N27/414 ,  B01D53/02

CPC分类号： G01N27/4141 ,  B01D53/025 ,  B01D2257/2064 ,  B01D2257/556 ,  B01D2257/70 ,  B01D2257/7022 ,  B01D2257/7027 ,  B82Y30/00 ,  G01N27/4146 ,  G01N27/4148

摘要： An improved sensing method is provided for rapid analyte detection. The method includes: applying an AC excitation signal to the channel region of the transistor; applying an AC drive signal to the transistor; delivering an analyte of interest to a channel region of a transistor; and monitoring a mixing current of the excitation signal and the drive signal through the transistor, where a change in the mixing current is indicative of the concentration of the analyte of interest.

摘要翻译： 提供了一种改进的感测方法用于快速分析物检测。 该方法包括：将AC激励信号施加到晶体管的沟道区; 将AC驱动信号施加到晶体管; 将感兴趣的分析物传送到晶体管的沟道区域; 以及通过晶体管监测激发信号和驱动信号的混合电流，其中混合电流的变化指示感兴趣的分析物的浓度。