公开(公告)号：US20230414536A1

公开(公告)日：2023-12-28

申请号：US18212500

申请日：2023-06-21

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman

IPC: A61K31/137 ,  A61P29/00 ,  A61P31/14 ,  A61K47/26

CPC classification number: A61K31/137 ,  A61P29/00 ,  A61P31/14 ,  A61K47/26

Abstract: The present disclosure provides methods for treating Post-Acute Sequelae of Severe Acute Respiratory Syndrome (SARS)-CoV-2 infection (PASC) or one or more symptoms associated with said PASC, comprising administering to a subject in need or at risk thereof a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

公开(公告)号：US20230149348A1

公开(公告)日：2023-05-18

申请号：US18075386

申请日：2022-12-05

Applicant: TONIX PHARMACEUTICALS HOLDING CORP

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

CPC classification number: A61K31/397 ,  A61K31/135 ,  A61K45/06 ,  C07C211/32 ,  C07D205/04

Abstract: The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US20220016268A1

公开(公告)日：2022-01-20

申请号：US17378642

申请日：2021-07-16

Applicant: TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMA LIMITED

Inventor： Seth Lederman ,  Siobhan J. Fogarty

IPC: A61K49/00 ,  C07K14/005

Abstract: The present disclosure provides methods for detecting cell-mediated immunity to SARS-CoV-2 in a subject, methods for detecting a cell-mediated immune response against SARS-CoV-2 in a subject and methods for determining if a vaccine against SARS-CoV-2 elicits a cell-mediated immune response in a subject, comprising administering to the skin of the subject one or more peptides.

公开(公告)号：US20200230104A1

公开(公告)日：2020-07-23

申请号：US16630832

申请日：2018-07-13

Applicant: Tonix Pharmaceuticals Holding Corp.

Inventor： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC: A61K31/397 ,  C07C211/32 ,  C07D205/04 ,  A61K45/06 ,  A61K31/135

Abstract: The present invention relates to cyclobenzaprine analogs useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.