公开(公告)号：US20070254892A1

公开(公告)日：2007-11-01

申请号：US11789548

申请日：2007-04-25

申请人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/519 ,  C07D487/02

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar 1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环 - 低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳族基团; R 2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R 3是氢原子或低级烷基; R 4是氢原子，卤素原子，羟基，低级烷基或-N（R 1）1个基团）的基团， SUP>; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US07834019B2

公开(公告)日：2010-11-16

申请号：US11789548

申请日：2007-04-25

申请人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/519 ,  A61K31/497 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US20080081811A1

公开(公告)日：2008-04-03

申请号：US11596735

申请日：2005-05-19

申请人： Yoshikazu Iwasawa ,  Jun Shibata ,  Tadashi Shimamura ,  Hideki Kurihara ,  Takashi Mita ,  Nobuhiko Kawanishi ,  Takashi Hashihayata ,  Mikako Kawamura ,  Takeshi Sagara ,  Sachie Arai ,  Hiroshi Hirai

发明人： Yoshikazu Iwasawa ,  Jun Shibata ,  Tadashi Shimamura ,  Hideki Kurihara ,  Takashi Mita ,  Nobuhiko Kawanishi ,  Takashi Hashihayata ,  Mikako Kawamura ,  Takeshi Sagara ,  Sachie Arai ,  Hiroshi Hirai

IPC分类号： A61K31/496 ,  A61K31/497 ,  A61K31/505 ,  A61K31/5377 ,  A61P35/00 ,  C07D239/32 ,  C07D403/14 ,  C07D413/14

CPC分类号： C07D417/14 ,  C07D417/12 ,  C07D491/08

摘要： The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 本发明涉及由式[I]表示的化合物：其中X是O，S，NH或CH 2; Y 1，Y 2，Y 3，Y 4和Y 5， 其可以相同或不同，各自为CH或N; 然而，Y 1，Y 2，Y 3，Y 4和Y 3中的至少一个， 5 是N; Z 1和Z 2可以相同或不同，各自为CH或N; n为1〜3的整数， R 1是C 3 -C 8环烷基，C 6 -C 10环烷基，C 6 -C 15环烷基， 芳基，脂族杂环或芳族杂环，或双环脂族饱和烃基; R 2和R 3可以相同或不同，分别为氢原子，低级烷基，低级烯基，C 3， C 1 -C 8环烷基，C 6 -C 10芳基，芳族杂环等; 和R 4是氢原子，低级烷基，C 3 -C 6环烷基等，或药学上可接受的 盐或酯，以及对Cdk4和/或Cdk6的选择性抑制剂或含有该化合物或其药学上可接受的盐或酯的抗癌剂。

公开(公告)号：US5409588A

公开(公告)日：1995-04-25

申请号：US83158

申请日：1993-06-25

申请人： Naofumi Mushiake ,  Takayuki Wani ,  Hiroshi Kato ,  Takeshi Sagara ,  Fumihiro Sasaki

发明人： Naofumi Mushiake ,  Takayuki Wani ,  Hiroshi Kato ,  Takeshi Sagara ,  Fumihiro Sasaki

IPC分类号： H01M2/16 ,  C25C7/04

CPC分类号： H01M2/1653 ,  Y10T428/249981 ,  Y10T428/31544 ,  Y10T428/31913

摘要： A porous composite material for diaphragms for high-output electrochemical cells such as lithium cells. The material is a layered structure of fluoropolymer and polyolefin that provides a shut-down capability that safeguards against dangerous failure of the cell, such as a rupture or fire that may result from a short-circuit or other high-rate electric discharge.

摘要翻译： 用于高输出电化学电池如锂电池的隔膜的多孔复合材料。 该材料是氟聚合物和聚烯烃的分层结构，其提供关闭能力，以防止电池的危险故障，例如可能由短路或其他高速率放电引起的断裂或火灾。

公开(公告)号：US20110183975A1

公开(公告)日：2011-07-28

申请号：US13122666

申请日：2009-09-28

申请人： Yasuhiro Goto ,  Takeshi Sagara ,  Weiming Fan ,  Thomas F. N. Hacell ,  Matthew G. Jenks ,  Michael J. Malaska ,  Joseph A. Moore, III ,  Gilles Ouvry ,  Bharathi Pandi ,  Michael R. Peel ,  Kimberty M. Steward

发明人： Yasuhiro Goto ,  Takeshi Sagara ,  Weiming Fan ,  Thomas F. N. Hacell ,  Matthew G. Jenks ,  Michael J. Malaska ,  Joseph A. Moore, III ,  Gilles Ouvry ,  Bharathi Pandi ,  Michael R. Peel ,  Kimberty M. Steward

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to a compound of formula I: wherein: R1 is C1-6 alkyl, C3-8 cycloalkyl, aryl, heterocyclyl, or —COR1x, where the C1-6 alkyl, C3-8 cycloalkyl, aryl, and heterocyclyl may be substituted; and R1x is C3-8 cycloalkyl, aryl, or heterocyclyl, any of which may be substituted; R2, R3, R4, R5, R6, and R7 are each independently hydrogen, halogen, C1-6 alkyl, or aryl, where the C1-6 alkyl or aryl may be substituted; R8 is hydrogen, C1-6 alkyl, aryl, or heterocyclyl, any of which may be substituted; or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 本发明涉及式I化合物：其中：R 1是C 1-6烷基，C 3-8环烷基，芳基，杂环基或-COR 1 x，其中C 1-6烷基，C 3-8环烷基，芳基和杂环基可以 被替代 并且R1x是C3-8环烷基，芳基或杂环基，其中任何一个可以被取代; R 2，R 3，R 4，R 5，R 6和R 7各自独立地为氢，卤素，C 1-6烷基或芳基，其中C 1-6烷基或芳基可以被取代; R8是氢，C1-6烷基，芳基或杂环基，其中任何一个可以被取代; 或其药学上可接受的盐或酯。

公开(公告)号：US20100213916A1

公开(公告)日：2010-08-26

申请号：US12096528

申请日：2006-12-05

申请人： Hirofumi Komori ,  Takeshi Sagara

发明人： Hirofumi Komori ,  Takeshi Sagara

IPC分类号： G05F1/10 ,  H03C3/06

CPC分类号： H03C3/095 ,  H04H20/48

摘要： An input signal is input via a first resistor to an inverting input terminal of an operational amplifier. A second resistor is provided on a feedback path between an output terminal and the inverting input terminal of the operational amplifier. A control voltage Vcnt output from the operational amplifier is input to a VCO. A frequency divider frequency-divides an output signal Sout of the VCO. A phase comparator compares an output signal from the frequency divider with a reference clock signal and outputs a voltage according to a phase difference. A loop filter removes a high-frequency component of an output voltage Vcp of the phase comparator and outputs the voltage to a non-inverting input terminal of the operational amplifier.

摘要翻译： 输入信号通过第一电阻输入到运算放大器的反相输入端。 第二电阻器设置在运算放大器的输出端子和反相输入端子之间的反馈路径上。 从运算放大器输出的控制电压Vcnt被输入到VCO。 分频器对VCO的输出信号Sout进行分频。 相位比较器将来自分频器的输出信号与参考时钟信号进行比较，并根据相位差输出电压。 环路滤波器去除相位比较器的输出电压Vcp的高频分量，并将该电压输出到运算放大器的非反相输入端。

公开(公告)号：US20100063024A1

公开(公告)日：2010-03-11

申请号：US12226707

申请日：2007-04-25

申请人： Toshihiro Sakamoto ,  Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Toshihiro Sakamoto ,  Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/397 ,  C07D487/04 ,  C07D413/14 ,  C07D417/14 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US20080103178A1

公开(公告)日：2008-05-01

申请号：US11974130

申请日：2007-10-11

申请人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

发明人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

IPC分类号： A61K31/454 ,  A61P25/00

CPC分类号： C07D403/04

摘要： The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphatic carbocyclic group. These compounds act as nociceptin receptor antagonist, and are useful, for example, as relievers against tolerance to narcotic analgesic, dependence on narcotic analgesic or addiction; analgesic enhancers; antiobestic or appetite suppressors; treating or prophylactic agents for cognitive impairment and dementia/amnesia; agents for treating developmental cognitive abnormality; remedy for schizophrenia; agents for treating neurodegenerative diseases; anti-depressant or treating agents for affective disorder; treating or prophylactic agents for diabetes insipidus; treating or prophylactic agents for polyuria; and remedy for hypotension and the like.

摘要翻译： 本发明提供由式（I）表示的化合物，其中R代表二羟基取代的C 1 -C 6烷基，Cy代表任选地 取代的C 6 -C 10 - 二环或三环脂族碳环基团。 这些化合物作为伤害感受肽受体拮抗剂起作用，例如可用作对麻醉止痛药的耐受性，对麻醉性镇痛药或成瘾的依赖; 镇痛增强剂; 抗生素或食欲抑制剂; 认知障碍和痴呆/遗忘症的治疗或预防剂; 治疗发育性认知异常的药剂; 精神分裂症补救措施 治疗神经变性疾病的药剂; 用于情感障碍的抗抑郁药或治疗剂; 尿崩症的治疗或预防剂; 多尿症的治疗或预防剂; 并补救低血压等。

公开(公告)号：US07300947B2

公开(公告)日：2007-11-27

申请号：US11484203

申请日：2006-07-11

申请人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

发明人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

IPC分类号： A01N43/40 ,  A01N43/52 ,  A61K31/445 ,  A61K31/415 ,  C07D211/32 ,  C07D403/02

CPC分类号： C07D403/04

摘要： The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphatic carbocyclic group. These compounds act as nociceptin receptor antagonist, and are useful, for example, as relievers against tolerance to narcotic analgesic, dependence on narcotic analgesic or addiction; analgesic enhancers; antiobestic or appetite suppressors; treating or prophylactic agents for cognitive impairment and dementia/amnesia; agents for treating developmental cognitive abnormality; remedy for schizophrenia; agents for treating neurodegenerative diseases; anti-depressant or treating agents for affective disorder; treating or prophylactic agents for diabetes insipidus; treating or prophylactic agents for polyuria; and remedy for hypotension and the like.

公开(公告)号：US20070237333A1

公开(公告)日：2007-10-11

申请号：US11786196

申请日：2007-04-11

申请人： Takeshi Sagara

发明人： Takeshi Sagara

IPC分类号： H04H5/00

CPC分类号： H04H20/48

摘要： The FM transmitter converts an input audio signal to a stereo composite signal, frequency-modulates the stereo composite signal and outputs the obtained signal. A stereo modulator stereo-modulates the output signal of the filter circuit, and converts the signal to the stereo composite signal. A frequency modulator frequency-modulates based on the stereo composite signal output from the stereo modulator. The filter circuit includes a pre-emphasis circuit, a low pass filter and the like, for example. At least one part of the filter circuit, that is, the low pass filter or the pre-emphasis circuit is configured with a switched capacitor filter.

摘要翻译： FM发射机将输入音频信号转换为立体声复合信号，对立体声复合信号进行频率调制并输出获得的信号。 立体声调制器对滤波器电路的输出信号进行立体声调制，并将该信号转换为立体声复合信号。 频率调制器基于从立体声调制器输出的立体声复合信号进行频率调制。 滤波电路例如包括预加重电路，低通滤波器等。 滤波器电路的至少一部分，即低通滤波器或预加重电路配置有开关电容滤波器。