公开(公告)号：US4889858A

公开(公告)日：1989-12-26

申请号：US180104

申请日：1988-02-17

申请人： Hitoshi Uno ,  Mikio Kurokawa ,  Fuminori Sato ,  Shunsuke Naruto ,  Yoshinobu Masuda

发明人： Hitoshi Uno ,  Mikio Kurokawa ,  Fuminori Sato ,  Shunsuke Naruto ,  Yoshinobu Masuda

IPC分类号： C07D313/12 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D401/12 ,  C07D313/12 ,  C07D409/12

摘要： The present invention relates to compounds represented by the general formula (I): ##STR1## wherein R.sub.1 is H or methoxy, R.sub.2 is H, methoxy, OH or F, R.sub.3 is H or F, R.sub.4 is H or F at 7-, 8- or 9-position, and .circle.Ar is a benzene, thiophene or pyridine ring, provided that (i) at least two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H, (ii) R.sub.2 or R.sub.3 is F when R.sub.4 is F, (iii) R.sub.1, R.sub.3 and R.sub.4 are H when R.sub.2 is methoxy or OH, (iv) R.sub.2 and R.sub.3 are not simultaneously F, and (v) R.sub.2 and R.sub.3 are H or F, and both R.sub.1 and R.sub.4 are H when .circle.Ar is a thiophene or pyridine ring, or a physiologically acceptable acid addition salt thereof. The compounds of the present invention have an excellent protective effect against cerebral anoxia and some of them have also an inhibitory effect on lipid peroxidation of mitochondrial membrane of brain and an anti-convulsant activity and are useful as an agent for prevention or treatment of cerebral diseases caused by hypoxia in mammals including human.

公开(公告)号：US4162316A

公开(公告)日：1979-07-24

申请号：US821918

申请日：1977-08-04

申请人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

发明人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

IPC分类号： C07D295/02 ,  C07D295/03 ,  C07D295/096 ,  C07D241/04 ,  A61K31/495

CPC分类号： C07D295/03 ,  C07D295/096

摘要： 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.

公开(公告)号：US06633224B1

公开(公告)日：2003-10-14

申请号：US09125402

申请日：1999-06-28

申请人： Toshihiro Hishida ,  Hidetaka Ohto ,  Hitoshi Uno ,  Kazunori Watanabe ,  Masakazu Kawano ,  Hiromi Wada ,  Yasunori Tanaka ,  Yoshifumi Yonemoto

发明人： Toshihiro Hishida ,  Hidetaka Ohto ,  Hitoshi Uno ,  Kazunori Watanabe ,  Masakazu Kawano ,  Hiromi Wada ,  Yasunori Tanaka ,  Yoshifumi Yonemoto

IPC分类号： G08B522

CPC分类号： G08B5/229

摘要： A radio pager system includes a radio pager that can receive messages and can specify a specific output mode, including a display, a sound output, a vibration, and a light emission appropriate to a particular type of message. The radio pager can further reduce difficulties in retransmitting and/or replying to messages and save time in the transmission period. The radio pager can receive and implement a radio message that includes control information which can be utilized for generating the specific output mode of the display.

摘要翻译： 无线寻呼机系统包括可以接收消息并且可以指定特定输出模式的无线寻呼机，包括显示器，声音输出，振动和适合于特定类型的消息的发光。 无线寻呼机可以进一步减少在重发和/或回复消息方面的困难，并节省传输时间。 无线寻呼机可以接收和实现包括可用于生成显示器的特定输出模式的控制信息的无线电消息。

公开(公告)号：US4172896A

公开(公告)日：1979-10-30

申请号：US912857

申请日：1978-06-05

申请人： Hitoshi Uno ,  Mikio Kurokawa ,  Yoshinobu Masuda

发明人： Hitoshi Uno ,  Mikio Kurokawa ,  Yoshinobu Masuda

IPC分类号： C07D261/20 ,  C07D263/56 ,  A61K31/42

CPC分类号： C07D263/56 ,  C07D261/20

摘要： Methane-sulfonamide derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen or a halogen atom, R.sub.2 and R.sub.3 are the same or different and are each hydrogen or a straight or branched alkyl having 1 to 3 carbon atoms, and one of X and Y is a carbon atom and another is a nitrogen atom, provided that the group: --CH.sub.2 SO.sub.2 NR.sub.2 R.sub.3 is bonded to the carbon atom of either of X and Y,and an alkali metal salt thereof, and a process for the preparation of said methane-sulfonamide derivatives. Said compounds have an excellent anticonvulsant activity and are useful as anticonvulsants for controlling convulsions and seizures in patients with epilepsy.

摘要翻译： 下式的甲磺酰胺衍生物：其中R 1是氢或卤素原子，R 2和R 3相同或不同，各自为氢或具有1至3个碳原子的直链或支链烷基， 的X和Y是碳原子，另一个是氮原子，条件是：-CH 2 SO 2 NR 2 R 3基团与X和Y中的任一个的碳原子键合，及其碱金属盐，以及制备所述 甲磺酰胺衍生物。 所述化合物具有优异的抗惊厥活性，可用作控制癫痫患者惊厥和癫痫发作的抗惊厥药。

公开(公告)号：US3988456A

公开(公告)日：1976-10-26

申请号：US561336

申请日：1975-03-24

申请人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

发明人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P9/12 ,  A61P11/14 ,  A61P25/00 ,  A61P25/04 ,  C07D213/74 ,  C07D295/084 ,  C07D295/10

CPC分类号： C07D295/092 ,  Y10S514/849

摘要： 1,2-Diphenylethanolamine derivatives of the formula: ##SPC1##Wherein R.sub.1 and R.sub.2 are each hydrogen, a halogen, nitro, hydroxy, an alkyl or methoxy; R.sub.3 is a group of the formula: ##SPC2##Wherein R.sub.4, R.sub.5 and R.sub.6 are each hydrogen, a halogen or methoxy and n is an integer of 0 to 3, or a pyridyl; and Z is hydroxy or an acyloxy; with proviso that when R.sub.1 and/or R.sub.2 are hydroxy, Z is hydroxy, and their pharmaceutically acceptable salts, which have excellent analgesic and anti-tussive activities, and a process for the preparation thereof.

摘要翻译： 下式的1,2-二苯乙醇胺衍生物：

公开(公告)号：US3983239A

公开(公告)日：1976-09-28

申请号：US557642

申请日：1975-03-12

申请人： Yasutaka Nagai ,  Hitoshi Uno ,  Masanao Shimizu ,  Tadahiko Karasawa

发明人： Yasutaka Nagai ,  Hitoshi Uno ,  Masanao Shimizu ,  Tadahiko Karasawa

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Hexahydro-.gamma.-carboline derivatives of the formula: ##SPC1##Wherein R.sub.1 is methyl or ethyl, and R.sub.2 is hydrogen, methyl or ethyl, with proviso that when R.sub.1 is ethyl, R.sub.2 is hydrogen, and their pharmaceutically acceptable acid addition salts, which exhibit excellent psychotropic effect, and a process for the preparation thereof.

摘要翻译： 下式的六氢-γ-咔啉衍生物：

公开(公告)号：US3957788A

公开(公告)日：1976-05-18

申请号：US541351

申请日：1975-01-15

申请人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

发明人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

IPC分类号： C07D295/02 ,  C07D295/03 ,  C07D295/096 ,  C07D295/145 ,  C07D295/08

CPC分类号： C07D295/03 ,  C07D295/096 ,  C07D295/145 ,  Y10S514/849

摘要： 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##SPC1##Wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl,And their pharmaceutically acceptable salts, which have excellent analgesic, anti-tussive and anti-inflammatory activities, without undesirable side effect such as narcotic activity, and a process for the preparation thereof.

公开(公告)号：US20060269197A1

公开(公告)日：2006-11-30

申请号：US10547768

申请日：2004-03-05

申请人： Hitoshi Uno ,  Hiroaki Asano ,  Hironori Souda ,  Syougo Horinouchi ,  Toshinori Kai ,  Toshihiro Koga ,  Masaharu Fukakusa

发明人： Hitoshi Uno ,  Hiroaki Asano ,  Hironori Souda ,  Syougo Horinouchi ,  Toshinori Kai ,  Toshihiro Koga ,  Masaharu Fukakusa

IPC分类号： G02B6/36

CPC分类号： G02B6/4246 ,  G02B6/4214 ,  H01L2224/48091 ,  H01L2224/48463 ,  H01L2224/73265 ,  H01L2924/3025 ,  H01S5/02252 ,  H01S5/02284 ,  H01S5/02292 ,  H01L2924/00014 ,  H01L2924/00

摘要： In a bidirectional optical module, a technique for attaining a miniaturization and a lower cost of a bidirectional optical module in which one optical fiber propagation path can be bused in two ways is disclosed. According to this technique, a molded product 12 is made of a transparent material, and a beam splitter layer 121 is inclined and embedded. A sub carrier 15 has a stage portion constituting an upper stage and a lower stage and is mounted on a flat top plane of a carrier 19. A semiconductor laser 14 is mounted on the upper stage of the sub-carrier, and a light receiving device 13 is mounted at a lower position of the molded product on the lower stage, and a side of the molded product is mounted on the side, and the respective planes are consequently bonded.

摘要翻译： 在双向光模块中，公开了一种用于实现双向光模块的小型化和低成本的技术，其中一个光纤传播路径可以以两种方式被布置。 根据该技术，模制品12由透明材料制成，并且分束器层121倾斜并嵌入。 副载体15具有构成上段和下段的载物台部分，并且安装在载体19的平坦顶平面上。半导体激光器14安装在副载体的上层上，并且光接收装置 13被安装在下阶段的模制品的下部位置，并且模制品的侧面安装在侧面上，并且因此粘合各个平面。

公开(公告)号：US20050248822A1

公开(公告)日：2005-11-10

申请号：US10525507

申请日：2003-08-26

申请人： Hitomaro Tohgoh ,  Hiroaki Asano ,  Hitoshi Uno ,  Masaki Kobayashi ,  Nobutaka Itabashi ,  Nobuyuki Akiya

发明人： Hitomaro Tohgoh ,  Hiroaki Asano ,  Hitoshi Uno ,  Masaki Kobayashi ,  Nobutaka Itabashi ,  Nobuyuki Akiya

IPC分类号： G02B6/42 ,  G03H1/00

CPC分类号： G02B6/421 ,  G02B6/4214 ,  G02B6/4246

摘要： A small-sized optical transceiver module, wherein any stress attributable to the differences in coefficient of thermal expansion between a transmission section optical system, a receiving section optical system, and the components which integrate and fix them and the like is not applied therebetween, and which is not influenced by any stress at the time of attachment/detachment of the optical connector is disclosed. The optical transceiver module is one wherein the transmission section optical system 1 which comprises a laser diode and an optical fiber or an optical waveguide optically connected to the laser diode and of which the electric input terminal of the laser diode is a flexible cable, a receiving section optical system 2 which comprises a photo diode and an optical fiber or an optical waveguide optically connected to the photo diode and of which the electric output terminal of the photo diode is a flexible cable, and an optical I/O optical receptacle 3 are optically connected, mechanically integrated and fixed, and the two flexible cables are spatially spaced out and disposed.

摘要翻译： 一种小尺寸的光收发模块，其中不会在其间施加归因于传输部分光学系统，接收部分光学系统和其组合和固定它们的部件之间的热膨胀系数差异的任何应力， 公开了在光连接器的附接/拆卸时不受任何应力的影响。 光收发器模块是其中传输部分光学系统1包括激光二极管和光纤或光学波导，光学连接到激光二极管，激光二极管的电输入端是柔性电缆，接收器 包括光电二极管和光纤或与光电二极管光学连接的光波导，其光电二极管的电输出端为柔性电缆，光学I / O光插座3为光学 连接，机械一体化和固定，并且两个柔性电缆在空间上间隔开并布置。

公开(公告)号：US5276509A

公开(公告)日：1994-01-04

申请号：US319475

申请日：1989-03-06

申请人： Shujiro Mizuno ,  Hitoshi Uno ,  Junji Hatamura ,  Kazunobu Asai ,  Eiichi Ohta ,  Hidetoshi Yano ,  Hiroya Inagaki ,  Kouichi Mino

发明人： Shujiro Mizuno ,  Hitoshi Uno ,  Junji Hatamura ,  Kazunobu Asai ,  Eiichi Ohta ,  Hidetoshi Yano ,  Hiroya Inagaki ,  Kouichi Mino

IPC分类号： H04N1/64 ,  G03G15/00

CPC分类号： H04N1/64

摘要： A method and apparatus for transmitting code data of a multi-color subject copy from a transmitter to a receiver in a manner that minimizes the volume of code data. The form of the data is determined by the capabilities of the receiver. The original images consist of at least two colors in addition to the background color of the copy sheet. A transmitter scans each line of the copy sheet to develop scan signals corresponding to the original images. The scan signals are used to prepare sets of run length code data and color discrimination code data indicative of the colors which appear in each line of the subject copy sheet. The transmitter transmits color discrimination code data and the corresponding set of run length code data to a receiver adapted to reproduce the transmitted data. The method of combining the scan signals to create the transmitted image signals and color discrimination code produce a condensed data strength.

摘要翻译： 一种用于以最小化码数据量的方式从发射机向接收机发送多色主体拷贝的码数据的方法和装置。 数据的形式由接收机的能力决定。 除了复印纸的背景颜色之外，原始图像至少包含两种颜色。 发射机扫描复印纸的每一行以形成对应于原始图像的扫描信号。 扫描信号用于准备游程长度代码数据和指示出现在主题复印纸的每一行中的颜色的颜色辨别代码数据。 发射机将颜色鉴别码数据和相应的游程长度码数据组发送到适于再现发送数据的接收机。 组合扫描信号以产生传输的图像信号和颜色鉴别码的方法产生浓缩的数据强度。