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11.发明申请公开(公告)号：US20160222107A1
公开(公告)日：2016-08-04
申请号：US15014145
申请日：2016-02-03
Applicant: UCB Biopharma SPRL
Inventor： Helene Margaret Finney , Terence Seward Baker , Alastair David Griffiths Lawson , Karen Margrete Miller , Marc Roger de Ryck , Christian Gilbert J. Wolff
IPC: C07K16/28 , A61K39/395
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
Abstract translation: 结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，使用抗体及其组合物在治疗中 ，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。
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公开(公告)号：US11692041B2
公开(公告)日：2023-07-04
申请号：US15743761
申请日：2016-07-15
Applicant: UCB Biopharma SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Kerry Louise Tyson , Michael John Wright
CPC classification number: C07K16/289 , C07K16/18 , C07K16/2803 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/76 , C07K2317/90
Abstract: The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.
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公开(公告)号：US10370447B2
公开(公告)日：2019-08-06
申请号：US15326501
申请日：2015-07-16
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright , Kerry Louise Tyson
Abstract: The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen CD22 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.
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Patent Agency Ranking
公开(公告)号：US10233243B2
公开(公告)日：2019-03-19
申请号：US14400812
申请日：2013-05-13
Applicant: UCB Biopharma SPRL
Inventor： Helene Margaret Finney , Alastair David Griffiths Lawson , Stevan Graham Shaw , Bryan John Smith , Kerry Louise Tyson , Lara Kevorkian , Christoph Meier , Kaushik Sarkar , Paul Alan Atherfold
IPC: C07K16/00 , C12P21/08 , A61K39/395 , C07K16/28 , G01N33/50 , G01N33/564 , G01N33/68 , A61K47/60 , A61K47/64 , C07K1/00 , A61K39/00
Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
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15.发明授权公开(公告)号：US09266953B2
公开(公告)日：2016-02-23
申请号：US14585406
申请日：2014-12-30
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Terence Seward Baker , Alastair David Griffiths Lawson , Karen Margrete Miller , Marc Roger de Ryck , Christian Gilbert J. Wolff
IPC: A61K39/395 , C12P21/08 , C07K16/00 , C07K16/28 , A61K39/00
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
Abstract translation: 结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，使用抗体及其组合物在治疗中 ，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。
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公开(公告)号：US10774152B2
公开(公告)日：2020-09-15
申请号：US15326499
申请日：2015-07-16
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright , Kerry Louise Tyson
Abstract: The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen CD45 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.
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公开(公告)号：US10358493B2
公开(公告)日：2019-07-23
申请号：US15311198
申请日：2015-05-28
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright
Abstract: The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry.
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公开(公告)号：US20150118240A1
公开(公告)日：2015-04-30
申请号：US14400812
申请日：2013-05-13
Applicant: UCB Biopharma SPRL
Inventor： Helene Margaret Finney , Alastair David Griffiths Lawson , Stevan Graham Shaw , Bryan John Smith , Kerry Louise Tyson , Lara Kevorkian , Christoph Meier , Kaushik Sarkar , Paul Alan Atherfold
IPC: C07K16/28 , G01N33/50 , G01N33/68 , A61K47/48 , A61K39/395
CPC classification number: C07K16/283 , A61K39/3955 , A61K47/60 , A61K47/643 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5047 , G01N33/564 , G01N33/6854 , G01N33/6857 , G01N33/6893 , G01N2333/70535 , G01N2500/02 , G01N2500/10 , G01N2800/104 , G01N2800/24 , G01N2800/28
Abstract: The disclosure relates to antibodies specific to FcRn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, DNA encoding the antibodies and hosts comprising said DNA.
Abstract translation: 本公开涉及对FcRn特异性的抗体，包含其的制剂，治疗中的每一种的使用，用于表达和任选配制所述抗体的方法，编码抗体的DNA和包含所述DNA的宿主。
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