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    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    13.
    发明申请
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权
    ALBUMIN BINDING抗体及其结合片段

    公开(公告)号：US20140302033A1

    公开(公告)日：2014-10-09

    申请号：US14356181

    申请日：2012-11-09

    Applicant: UCB PHARMA S.A.

    Inventor： Ralph Adams ,  Pavalli Bhatta ,  Sam Phillip Heywood ,  David Paul Humphreys

    IPC: C07K16/18

    CPC classification number: C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    Abstract translation: 1.一种血清白蛋白结合抗体或其片段，其包含具有SEQ ID NO：1或SEQ ID NO：2中给出的序列的重链可变结构域和/或包含具有SEQ ID NO：3中给出的序列的轻链可变区或 SEQ ID NO：4，特别包括具有SEQ ID NO：1和SEQ ID NO：3中给出的序列的重链可变结构域和轻链可变区或重链可变结构域和具有 SEQ ID NO：2和SEQ ID NO：4中给出的序列。 本公开还延伸到编码抗体或片段的多核苷酸，包含其的载体和能够表达多核苷酸的宿主细胞。 本公开还包括药物组合物，其包含使用其中任何一种的抗体或片段和治疗剂。

    Multivalent antibodies
    15.
    发明授权
    Multivalent antibodies 有权

    公开(公告)号：US10421816B2

    公开(公告)日：2019-09-24

    申请号：US15165131

    申请日：2016-05-26

    Applicant: UCB PHARMA S.A.

    Inventor： Ralph Adams ,  Emma Dave ,  David Paul Humphreys

    IPC: C07K16/46 ,  C07K16/28 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18

    Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

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