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    Multivalent Antibodies
    1.
    发明申请
    Multivalent Antibodies 审中-公开
    多价抗体

    公开(公告)号：US20160333105A1

    公开(公告)日：2016-11-17

    申请号：US15165131

    申请日：2016-05-26

    申请人： UCB PHARMA S.A.

    发明人： Ralph Adams ,  Emma Dave ,  David Paul Humphreys

    IPC分类号： C07K16/28 ,  C07K16/18

    摘要： The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    摘要翻译： 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。

    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    7.
    发明申请
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权
    ALBUMIN BINDING抗体及其结合片段

    公开(公告)号：US20140302033A1

    公开(公告)日：2014-10-09

    申请号：US14356181

    申请日：2012-11-09

    申请人： UCB PHARMA S.A.

    发明人： Ralph Adams ,  Pavalli Bhatta ,  Sam Phillip Heywood ,  David Paul Humphreys

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    摘要： A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    摘要翻译： 1.一种血清白蛋白结合抗体或其片段，其包含具有SEQ ID NO：1或SEQ ID NO：2中给出的序列的重链可变结构域和/或包含具有SEQ ID NO：3中给出的序列的轻链可变区或 SEQ ID NO：4，特别包括具有SEQ ID NO：1和SEQ ID NO：3中给出的序列的重链可变结构域和轻链可变区或重链可变结构域和具有 SEQ ID NO：2和SEQ ID NO：4中给出的序列。 本公开还延伸到编码抗体或片段的多核苷酸，包含其的载体和能够表达多核苷酸的宿主细胞。 本公开还包括药物组合物，其包含使用其中任何一种的抗体或片段和治疗剂。

    Biological Products
    9.
    发明申请
    Biological Products 审中-公开

    公开(公告)号：US20200048372A1

    公开(公告)日：2020-02-13

    申请号：US16508967

    申请日：2019-07-11

    申请人： UCB PHARMA S.A.

    发明人： Ralph Adams ,  Laura Hancock ,  Sam Philip Heywood

    IPC分类号： C07K16/46 ,  C07K16/28 ,  C07K16/24 ,  C07K16/18

    摘要： A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab′ fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.