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    Multivalent antibodies
    4.
    发明授权
    Multivalent antibodies 有权

    公开(公告)号：US10421816B2

    公开(公告)日：2019-09-24

    申请号：US15165131

    申请日：2016-05-26

    Applicant: UCB PHARMA S.A.

    Inventor： Ralph Adams ,  Emma Dave ,  David Paul Humphreys

    IPC: C07K16/46 ,  C07K16/28 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18

    Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    Multivalent Antibodies
    9.
    发明申请
    Multivalent Antibodies 审中-公开
    多价抗体

    公开(公告)号：US20160333105A1

    公开(公告)日：2016-11-17

    申请号：US15165131

    申请日：2016-05-26

    Applicant: UCB PHARMA S.A.

    Inventor： Ralph Adams ,  Emma Dave ,  David Paul Humphreys

    IPC: C07K16/28 ,  C07K16/18

    Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    Abstract translation: 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。

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