公开(公告)号：US20200231969A1

公开(公告)日：2020-07-23

申请号：US16696635

申请日：2019-11-26

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12N15/11 ,  C12Q1/6883

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US10196639B2

公开(公告)日：2019-02-05

申请号：US15288415

申请日：2016-10-07

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12N5/00

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.

公开(公告)号：US09745577B2

公开(公告)日：2017-08-29

申请号：US14741071

申请日：2015-06-16

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/68 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33 ,  C12Q1/6883

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US09714422B2

公开(公告)日：2017-07-25

申请号：US15148303

申请日：2016-05-06

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/68 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33 ,  C12Q1/6883

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US20160017322A1

公开(公告)日：2016-01-21

申请号：US14741071

申请日：2015-06-16

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33 ,  C12Q1/6883

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.