公开(公告)号：US12285636B2

公开(公告)日：2025-04-29

申请号：US17881026

申请日：2022-08-04

Applicant: University of Washington

Inventor： Michael R. Bailey ,  Mohamed Abdalla Ghanem ,  Adam D. Maxwell

IPC: A61N7/00 ,  B29D11/00 ,  G02B5/32

Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.

公开(公告)号：US12157018B2

公开(公告)日：2024-12-03

申请号：US16712680

申请日：2019-12-12

Applicant: University of Washington ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE NETHERLANDS

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02 ,  A61B17/22

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US09867999B2

公开(公告)日：2018-01-16

申请号：US15309394

申请日：2015-05-15

Applicant: University of Washington ,  The Regents of the University of Michigan

Inventor： Adam D. Maxwell ,  Bryan Cunitz ,  Michael R. Bailey ,  Vera Khokhlova ,  Timothy L. Hall

IPC: A61N7/00 ,  A61B17/22 ,  B06B1/02 ,  A61N7/02 ,  G01S7/52

CPC classification number: A61N7/00 ,  A61B17/22004 ,  A61N7/02 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0095 ,  B06B1/0215 ,  B06B2201/55 ,  G01S7/5202

Abstract: Embodiments of the invention include improved radiofrequency (RF) pulse amplifier systems that incorporate an energy array comprising multiple capacitors connected in parallel. The energy array extends the maximum length of pulses and the maximum achievable peak power output of the amplifier when compared to similar systems. Embodiments also include systems comprising the amplifier configured to drive a load, wherein the load may include one or more ultrasound (e.g., piezoelectric) transducers Related methods of using the amplifier are also provided.

公开(公告)号：US09743909B1

公开(公告)日：2017-08-29

申请号：US14278197

申请日：2014-05-15

Applicant: University of Washington through its Center for Commercialization

Inventor： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Joo Ha Hwang ,  Tatiana D. Khokhlova ,  Vera Khokhlova ,  Matthew O'Donnell ,  Tong Li

IPC: A61N7/02 ,  A61B8/08 ,  A61B5/05 ,  A61B5/00

CPC classification number: A61B8/481 ,  A61B5/0051 ,  A61B5/0062 ,  A61B5/0507 ,  A61N7/00

Abstract: A method for imaging a cavitation bubble includes producing a vibratory wave that induces a cavitation bubble in a medium, producing one or more detection waves directed toward the induced cavitation bubble, receiving one or more reflection waves, identifying a change in one or more characteristics of the induced cavitation bubble, and generating an image of the induced cavitation bubble using a computing device on the basis of the identified change in the one or more characteristics. The one or more received reflection waves correspond to at least one of the one or more produced detection waves reflection from the induced cavitation bubble. The identified change in one or more characteristics corresponds to the one or more received reflection waves.

公开(公告)号：US09588491B2

公开(公告)日：2017-03-07

申请号：US13894333

申请日：2013-05-14

Applicant: University of Washington through its Center for Commercialization

Inventor： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Peter J. Kaczkowski ,  Vera A. Khokhlova ,  Wayne Kreider

IPC: G03H3/00 ,  A61B8/00 ,  G01N29/06

CPC classification number: G03H3/00 ,  A61B8/00 ,  G01N29/0663 ,  Y10S359/901

Abstract: The present technology relates generally to portable acoustic holography systems for therapeutic ultrasound sources, and associated devices and methods. In some embodiments, a method of characterizing an ultrasound source by acoustic holography includes the use of a transducer geometry characteristic, a transducer operation characteristic, and a holography system measurement characteristic. A control computer can be instructed to determine holography measurement parameters. Based on the holography measurement parameters, the method can include scanning a target surface to obtain a hologram. Waveform measurements at a plurality of points on the target surface can be captured. Finally, the method can include processing the measurements to reconstruct at least one characteristic of the ultrasound source.

Abstract translation: 本技术一般涉及用于治疗性超声源的便携式声全息系统，以及相关的装置和方法。 在一些实施例中，通过声全息技术来表征超声源的方法包括使用换能器几何特征，换能器操作特性和全息系统测量特性。 可以指示控制计算机来确定全息测量参数。 基于全息测量参数，该方法可以包括扫描目标表面以获得全息图。 可以捕获目标表面上的多个点处的波形测量。 最后，该方法可以包括处理测量以重建超声源的至少一个特征。

公开(公告)号：US12167864B1

公开(公告)日：2024-12-17

申请号：US18151013

申请日：2023-01-06

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

公开(公告)号：US11583299B1

公开(公告)日：2023-02-21

申请号：US16295607

申请日：2019-03-07

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: A method for attempting to fragment or comminute an object in a body using ultrasound includes producing a burst wave lithotripsy (BWL) waveform by a therapy transducer. The BWL waveform is configured to fragment or comminute the object. The BWL waveform includes a first burst of continuous ultrasound cycles and a second burst of continuous ultrasound cycles. A burst frequency corresponds to a frequency of repeating the bursts of the BWL waveform. The method also includes determining a cycle frequency f of the continuous ultrasound cycles within the first burst and the second burst based on a target fragment size D, where the cycle frequency is: f(MHz)=0.47/D(mm).

公开(公告)号：US20230038081A1

公开(公告)日：2023-02-09

申请号：US17881026

申请日：2022-08-04

Applicant: University of Washington

Inventor： Michael R. Bailey ,  Mohamed Abdalla Ghanem ,  Adam D. Maxwell

IPC: A61N7/00 ,  G02B5/32 ,  B29D11/00

Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.

公开(公告)号：US10251657B1

公开(公告)日：2019-04-09

申请号：US14268414

申请日：2014-05-02

Applicant: University of Washington through its Center for Commercialization

Inventor： Adam D. Maxwell ,  Bryan W. Cunitz ,  Wayne Kreider ,  Oleg A. Sapozhnikov ,  Ryan S. Hsi ,  Michael R. Bailey

IPC: A61B17/22

Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.

公开(公告)号：US10136835B1

公开(公告)日：2018-11-27

申请号：US13875973

申请日：2013-05-02

Applicant: University of Washington through its Center for Commercialization

Inventor： Michael R. Bailey ,  Wei Lu ,  Oleg A. Sapozhnikov ,  Bryan Cunitz

IPC: A61B5/00 ,  A61B5/06 ,  A61B8/08

Abstract: Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state.