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29 条记录 (耗时 0.026 秒)

    Suppressing polyglutamine aggregation and toxicity
    13.
    发明申请
    Suppressing polyglutamine aggregation and toxicity 审中-公开
    抑制聚谷氨酰胺聚集和毒性

    公开(公告)号：US20070244057A1

    公开(公告)日：2007-10-18

    申请号：US11656048

    申请日：2007-01-22

    申请人： Henry Paulson ,  Victor Miller

    发明人： Henry Paulson ,  Victor Miller

    IPC分类号： A61K38/07 ,  A61K38/06 ,  A61P25/28 ,  C12N5/06 ,  C12N5/08 ,  C12N5/10

    CPC分类号： A61K38/1703

    摘要： It has been discovered that CHIP suppresses polyglutamine aggregation and toxicity in transfected cell lines, primary neurons and a novel zebrafish model of disease. Accordingly, certain embodiments of the present invention provide methods for decreasing the formation of an inclusion or aggregation of a protein or for increasing the solubility of a protein in a cell, comprising increasing the amount of C-terminal heat shock protein 70-interacting protein (CHIP) or a functional subunit of CHIP in the cell. Additionally, certain embodiments of the present invention provide methods for treating a subject that has a neurodegenerative disease or preventing a neurodegenerative disease in a subject, comprising administering to the subject a treatment effective to increase the amount of CHIP, or a functional subunit thereof, in cells of the subject.

    摘要翻译： 已经发现，CHIP抑制转染细胞系，原代神经元和新型斑马鱼疾病模型中的多聚谷氨酰胺聚集和毒性。 因此，本发明的某些实施方案提供了减少蛋白质的包合物或聚集物的形成或增加蛋白质在细胞中的溶解度的方法，包括增加C末端热休克蛋白70相互作用蛋白质的量 CHIP）或细胞中CHIP的功能亚基。 另外，本发明的某些实施方案提供了治疗患有神经变性疾病或预防受试者的神经变性疾病的受试者的方法，包括向受试者施用有效增加CHIP或其功能亚基的量的治疗， 受试者的细胞。

    Device and method for preventing magnetic-resonance imaging induced damage
    19.
    发明申请
    Device and method for preventing magnetic-resonance imaging induced damage 审中-公开
    磁共振成像诱发损伤的装置及方法

    公开(公告)号：US20050113873A1

    公开(公告)日：2005-05-26

    申请号：US10795741

    申请日：2004-03-08

    申请人： Michael Weiner ,  Victor Miller ,  Patrick Connelly ,  Jeffrey Helfer

    发明人： Michael Weiner ,  Victor Miller ,  Patrick Connelly ,  Jeffrey Helfer

    IPC分类号： G01R33/28 ,  G01R33/48 ,  G01R33/54 ,  A61N1/00

    CPC分类号： G01R33/285 ,  A61N1/086 ,  G01R33/288 ,  G01R33/4804 ,  Y10T428/24322 ,  Y10T428/24331

    摘要： An electromagnetic shield has a first patterned or apertured layer having non-conductive materials and conductive material and a second patterned or apertured layer having non-conductive materials and conductive material. The conductive material may be a metal, a carbon composite, or a polymer composite. The non-conductive materials in the first patterned or apertured layer may be randomly located or located in a predetermined segmented pattern such that the non-conductive materials in the first patterned or apertured layer are located in a predetermined segmented pattern with respect to locations of the non-conductive materials in the second patterned or apertured layer.

    摘要翻译： 电磁屏蔽具有具有非导电材料和导电材料的第一图案化或有孔层，以及具有非导电材料和导电材料的第二图案化或有孔层。 导电材料可以是金属，碳复合材料或聚合物复合材料。 第一图案化或有孔层中的非导电材料可以是随机位置或位于预定的分段图案中，使得第一图案化或有孔层中的非导电材料相对于 在第二图案或多孔层中的非导电材料。