公开(公告)号：US20150018517A1

公开(公告)日：2015-01-15

申请号：US14457064

申请日：2014-08-11

Applicant: VisEn Medical, Inc.

Inventor： Milind Rajopadhye ,  Kevin Groves ,  Dorin V. Preda

IPC: A61K49/00

CPC classification number: A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Abstract translation: 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。

公开(公告)号：US08771646B2

公开(公告)日：2014-07-08

申请号：US13828648

申请日：2013-03-14

Applicant: VisEn Medical, Inc.

Inventor： Milind Rajopadhye ,  Narasimhachari Narayanan ,  Jeffrey D. Peterson

IPC: A61K49/00 ,  C07D401/06

CPC classification number: A61K49/0032 ,  A61K49/0021 ,  C07D401/06 ,  C07D401/14 ,  C07D417/06 ,  C09B23/0008 ,  C09B23/083

Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

Abstract translation: 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。