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    Nicotinic Acid and Picolinic Acid Derived Near-Infrared Fluorophores
    1.
    发明申请
    Nicotinic Acid and Picolinic Acid Derived Near-Infrared Fluorophores 有权
    烟酸和吡啶酸衍生的近红外荧光团

    公开(公告)号：US20130272967A1

    公开(公告)日：2013-10-17

    申请号：US13828648

    申请日：2013-03-14

    Applicant: VisEn Medical, Inc.

    Inventor： Milind Rajopadhye ,  Narasimhachari Narayanan ,  Jeffrey D. Peterson

    IPC: A61K49/00

    CPC classification number: A61K49/0032 ,  A61K49/0021 ,  C07D401/06 ,  C07D401/14 ,  C07D417/06 ,  C09B23/0008 ,  C09B23/083

    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

    Abstract translation: 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。

    METHODS AND COMPOSITIONS FOR IDENTIFYING SUBJECTS AT RISK OF DEVELOPING STENT THROMBOSIS
    2.
    发明申请
    METHODS AND COMPOSITIONS FOR IDENTIFYING SUBJECTS AT RISK OF DEVELOPING STENT THROMBOSIS 审中-公开
    用于识别发展中的STETH THROMBOSIS风险的方法和组合物

    公开(公告)号：US20150133773A1

    公开(公告)日：2015-05-14

    申请号：US14501610

    申请日：2014-09-30

    Applicant: VisEn Medical, Inc.

    Inventor： Farouc Jaffer ,  Milind Rajopadhye

    IPC: A61B5/00 ,  A61F2/82 ,  A61B1/04 ,  A61B19/00 ,  A61B5/06 ,  A61K49/00

    CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/066 ,  A61B5/4851 ,  A61B5/7275 ,  A61B90/20 ,  A61B2576/02 ,  A61F2/82 ,  A61K49/0034 ,  A61K49/0097

    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.

    Abstract translation: 本发明提供了用于确定含有固定在血管中的支架的受试者是否具有无症状的支架内血栓形成或具有发展为临床症状性支架内血栓形成的风险的方法和组合物。 在一种方法中，该方法涉及使用包含荧光染料（例如近红外荧光染料）的探针对含有支架的血管的区域成像，以及结合指示存在无症状的分子标记的靶向部分 支架血栓形成或症状性支架血栓形成的发展。 在受试者显示一种或多种这样的标记物的程度上，探针结合标记并增加探针在支架附近的局部浓度。 成像方法识别那些在支架附近显示较高密度的标记物的患者。 因此，可以监测和/或治疗这些患者以防止症状性支架内血栓形成。

    Methods and compositions for identifying subjects at risk of developing stent thrombosis
    4.
    发明授权
    Methods and compositions for identifying subjects at risk of developing stent thrombosis 有权

    公开(公告)号：US10092188B2

    公开(公告)日：2018-10-09

    申请号：US14501610

    申请日：2014-09-30

    Applicant: VisEn Medical, Inc.

    Inventor： Farouc Jaffer ,  Milind Rajopadhye

    IPC: A61B6/00 ,  A61B5/00 ,  A61B5/02 ,  A61K49/00 ,  A61B1/04 ,  A61B5/06 ,  A61F2/82 ,  A61B90/20

    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.

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