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公开(公告)号：US12110283B2
公开(公告)日：2024-10-08
申请号：US17372029
申请日：2021-07-09
Applicant: VisEn Medical, Inc.
Inventor： Kevin Groves , Bagna Bao
IPC: C07D401/06 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/00 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , C09B23/01 , C09B23/08 , G01N21/64 , G01N33/58
CPC classification number: C07D401/06 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/0002 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , C09B23/0008 , C09B23/0033 , C09B23/083 , C09B23/086 , G01N21/6458 , G01N33/582 , G01N2333/988 , Y02A50/30
Abstract: The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
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公开(公告)号：US20170283617A1
公开(公告)日：2017-10-05
申请号：US15433688
申请日：2017-02-15
Applicant: VisEn Medical, Inc.
Inventor： Narasimhachari Narayanan , Kevin Groves , Jeffrey D. Peterson , Milind Rajopadhye
IPC: A61K49/00 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/01 , C09B23/08 , G01N33/533 , G01N33/537 , C07D209/14 , G01N33/58
CPC classification number: C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
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公开(公告)号：US20190300501A1
公开(公告)日：2019-10-03
申请号：US16286901
申请日：2019-02-27
Applicant: VisEn Medical, Inc.
Inventor： Kevin Groves , Bagna Bao
IPC: C07D401/06 , A61K31/4439 , C07D209/60 , C07D401/14 , C07D417/14 , C09B23/08 , C09B23/01 , G01N21/64 , A61K31/506 , A61K31/444 , C07D209/14 , A61K31/433 , G01N33/58 , A61K49/00
Abstract: The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
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公开(公告)号：US09999687B2
公开(公告)日：2018-06-19
申请号：US15250038
申请日：2016-08-29
Applicant: VisEn Medical, Inc.
Inventor： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
CPC classification number: A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
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公开(公告)号：US09649389B2
公开(公告)日：2017-05-16
申请号：US14215979
申请日：2014-03-17
Applicant: VisEn Medical, Inc.
Inventor： Kevin Groves , Ryan Buff
IPC: A61B5/00 , A61B8/00 , A61B10/00 , A61K47/48 , C07F7/08 , C09B11/28 , C09B69/00 , G01N33/569 , A61K49/00
CPC classification number: A61K47/48023 , A61K47/48092 , A61K47/48384 , A61K49/0019 , A61K49/0021 , A61K49/0052 , A61K49/0054 , C07F7/0816 , C09B11/28 , C09B69/008 , G01N33/56966
Abstract: The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.
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Patent Agency Ranking
公开(公告)号：US20220023277A1
公开(公告)日：2022-01-27
申请号：US17372029
申请日：2021-07-09
Applicant: VisEn Medical, Inc.
Inventor： Kevin Groves , Bagna Bao
IPC: A61K31/4439 , A61K49/00
Abstract: The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
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公开(公告)号：US11059802B2
公开(公告)日：2021-07-13
申请号：US16286901
申请日：2019-02-27
Applicant: VisEn Medical, Inc.
Inventor： Kevin Groves , Bagna Bao
IPC: C07D401/06 , C07D401/14 , C07D417/14 , A61K49/00 , G01N33/58 , C09B23/08 , G01N21/64 , C07D209/14 , C07D209/60 , C09B23/01 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506
Abstract: The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
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公开(公告)号：US10442930B2
公开(公告)日：2019-10-15
申请号：US15433688
申请日：2017-02-15
Applicant: VisEn Medical, Inc.
Inventor： Narasimhachari Narayanan , Kevin Groves , Jeffrey D. Peterson , Milind Rajopadhye
IPC: C09B23/08 , C09B23/01 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , A61K49/00 , G01N33/533 , G01N33/537 , G01N33/58
Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
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公开(公告)号：US20170119908A1
公开(公告)日：2017-05-04
申请号：US15250038
申请日：2016-08-29
Applicant: VisEn Medical, Inc.
Inventor： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
CPC classification number: A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
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公开(公告)号：US09427481B2
公开(公告)日：2016-08-30
申请号：US14457064
申请日：2014-08-11
Applicant: VisEn Medical, Inc.
Inventor： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
IPC: A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K49/00 , A61K47/48 , C09B23/01 , C09B23/08
CPC classification number: A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
Abstract translation: 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。
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