公开(公告)号：US20060217770A1

公开(公告)日：2006-09-28

申请号：US11419284

申请日：2006-05-19

申请人： Walter Olson

发明人： Walter Olson

IPC分类号： A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/0563 ,  A61N1/375 ,  A61N1/3918 ,  A61N1/3956 ,  A61N1/3968 ,  A61N1/3981

摘要： Implantable cardioverter-defibrillators (ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion/defibrillation and pace/sense electrodes for delivery of cardioversion/defibrillation shock and pacing therapies across the heart when necessary. At least two hermetically sealed housings forming first and second hermetically sealed housings coupled together by a cable support first, second and, optionally, third cardioversion/defibrillation electrodes. The relatively bulky high voltage battery and high voltage capacitors, and circuitry powered by a low voltage power source for detecting a tachyarrhythmia, charging the high voltage capacitor, and discharging the high voltage capacitor to provide a cardioversion/defibrillation shock are distributed between the first and second hermetically sealed housings.

摘要翻译： 公开了植入式心律转复除颤器（ICD），其完全可植入皮下，以最小的手术入侵患者身体，并提供分布式心脏复律/除颤和步调/感应电极，用于在需要时在整个心脏递送心脏复律/除颤休克和起搏疗法 。 至少两个气密密封的壳体形成第一和第二密封壳体，其通过电缆支撑件第一，第二以及任选的第三心电复律/除颤电极耦合在一起。 相对庞大的高电压电池和高压电容器以及由用于检测快速性心律失常的低压电源供电的电路，对高压电容器充电以及对高压电容器进行放电以提供心脏复律/除颤电击分布在第一和 第二个密封的外壳。

公开(公告)号：US20060163323A1

公开(公告)日：2006-07-27

申请号：US11044938

申请日：2005-01-27

申请人： Norman Pietruska ,  Walter Olson ,  Beth Abriles ,  David Rutz

发明人： Norman Pietruska ,  Walter Olson ,  Beth Abriles ,  David Rutz

IPC分类号： A47J36/02

CPC分类号： B23P6/007 ,  C23C4/18 ,  C23C24/04 ,  F01D5/28 ,  F05D2230/80 ,  Y02T50/67

摘要： Novel materials and methods for repairing/reclassifying superalloy components are described herein. These materials are non-traditional blends of materials having a much higher base material content than traditional repair/reclassification materials. In embodiments used to repair/reclassify nickel-based components, these materials may comprise about 5-18.9 weight percent of a low melting point alloy and about 81.1-95 weight percent of a base material. In embodiments used to repair/reclassify cobalt-based components, these materials may comprise about 15-30 weight percent of a low melting point alloy and about 70-85 weight percent of a base material. These materials can be used to repair surface defects and/or build up worn or eroded areas of a component to meet precise dimensional and metallurgical requirements. These materials create robust repaired components having a dense, isothermally solidified structure having minimal borides and a high re-melt temperature.

摘要翻译： 本文描述了用于修复/重新分级超级合金部件的新型材料和方法。 这些材料是非传统的材料混合物，其具有比传统的修复/重新分类材料高得多的基础材料含量。 在用于修复/重新分类镍基组分的实施方案中，这些材料可以包含约5-18.9重量％的低熔点合金和约81.1-95重量％的基材。 在用于修复/重新分类钴基组分的实施方案中，这些材料可以包含约15-30重量％的低熔点合金和约70-85重量％的基材。 这些材料可用于修复表面缺陷和/或构建组件的磨损或侵蚀区域，以满足精确的尺寸和冶金要求。 这些材料产生具有致密的，等温凝固的具有最小硼化物和高再熔融温度的结构的稳固的修复组分。

公开(公告)号：US20060088503A1

公开(公告)日：2006-04-27

申请号：US11249948

申请日：2005-10-13

申请人： Vinod Sharma ,  Orhan Soykan ,  Maura Donovan ,  Walter Olson

发明人： Vinod Sharma ,  Orhan Soykan ,  Maura Donovan ,  Walter Olson

IPC分类号： A01N63/00

CPC分类号： A61L27/3873 ,  A61K9/0024 ,  A61K38/00 ,  A61K48/005 ,  A61L27/227 ,  A61L27/3834 ,  C07K14/705

摘要： A method for decreasing risk of ventricular tachycardia following myocardial infarction increases cell-to-cell coupling and/or excitability in the border zone of an infarcted region of myocardial tissue. Enhanced conduction to treat the border zone is carried out by genetically modifying myocytes in the border zone to form more gap junctions and/or sodium channels and/or calcium channels. Alternatively, enhanced conduction is carried out by incorporating cells into the border zone that form gap junctions with the myocytes and/or form sodium channels and/or form calcium channels.

摘要翻译： 降低心肌梗死后室性心动过速风险的方法增加了心肌组织梗塞区域边界区的细胞间电偶耦合和/或兴奋性。 通过在边界区域中遗传修饰肌细胞以形成更多的间隙连接和/或钠通道和/或钙通道来进行治疗边界区域的增强传导。 或者，通过将细胞并入到与肌细胞形成间隙连接和/或形成钠通道和/或形成钙通道的边界区域中来进行增强的传导。

公开(公告)号：US20050055056A1

公开(公告)日：2005-03-10

申请号：US10717395

申请日：2003-11-19

申请人： Walter Olson

发明人： Walter Olson

IPC分类号： A61N1/362 ,  A61N1/375 ,  A61N1/39

CPC分类号： A61N1/3622 ,  A61N1/0563 ,  A61N1/375 ,  A61N1/3918 ,  A61N1/3956 ,  A61N1/3968 ,  A61N1/3981

摘要： Implantable cardioverter-defibrillators (ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion/defibrillation and pace/sense electrodes for delivery of cardioversion/defibrillation shock and pacing therapies across the heart when necessary. At least two hermetically sealed housings forming first and second hermetically sealed housings coupled together by a cable support first, second and, optionally, third cardioversion/defibrillation electrodes. The relatively bulky high voltage battery and high voltage capacitors, and circuitry powered by a low voltage power source for detecting a tachyarrhythmia, charging the high voltage capacitor, and discharging the high voltage capacitor to provide a cardioversion/defibrillation shock are distributed between the first and second hermetically sealed housings.

摘要翻译： 公开了植入式心律转复除颤器（ICD），其完全可植入皮下，以最小的手术入侵患者身体，并提供分布式心脏复律/除颤和步调/感应电极，用于在需要时在整个心脏递送心脏复律/除颤休克和起搏疗法 。 至少两个气密密封的壳体形成第一和第二密封壳体，其通过电缆支撑件第一，第二以及任选的第三心电复律/除颤电极耦合在一起。 相对庞大的高电压电池和高压电容器以及由用于检测快速性心律失常的低压电源供电的电路，对高压电容器充电以及对高压电容器进行放电以提供心脏复律/除颤电击分布在第一和 第二个密封的外壳。