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    Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
    14.
    发明申请
    Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors 有权
    可用作激酶抑制剂的苯并噻唑和氮杂苯并噻唑化合物

    公开(公告)号：US20070185175A1

    公开(公告)日：2007-08-09

    申请号：US11494234

    申请日：2006-07-27

    申请人： Chunjian Liu ,  Katerina Leftheris ,  James Lin

    发明人： Chunjian Liu ,  Katerina Leftheris ,  James Lin

    IPC分类号： A61K31/428 ,  C07D417/02

    CPC分类号： C07D513/04 ,  C07D417/04

    摘要： A compound of Formula (I) or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein. Also disclosed is a compound of Formula (II) or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

    摘要翻译： 式（I）的化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中A独立地选自：其中R 1，R 2，R 2， R 4，R 4，R 5，R 6，R 7和/或R 4， W如本文所述。 还公开了式（II）的化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中G，X和Y各自独立地为CH或N，其中在每次出现时，G，X或 Y为N，G，X或Y中的两个为CH; 并且B独立地选自：其中R 1，R 2，R 3，R 4，R 4，R 4， R 5，R 9，R 9和Z如本文所述。 还公开了含有式（I）和式（II）化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

    BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
    19.
    发明申请
    BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
    苯并噻唑和亚苄基唑类化合物作为激酶抑制剂有用

    公开(公告)号：US20090118272A1

    公开(公告)日：2009-05-07

    申请号：US12333425

    申请日：2008-12-12

    申请人： Chunjian Liu ,  Katerina Leftheris ,  James Lin

    发明人： Chunjian Liu ,  Katerina Leftheris ,  James Lin

    IPC分类号： A61K31/428 ,  C07D417/14 ,  C07D417/10 ,  A61K31/5377 ,  A61K31/4439 ,  A61P29/00 ,  A61K31/454 ,  A61K31/437 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D417/04

    摘要： A compound of Formula (I) an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein.Also disclosed is a compound of Formula (II) an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein.Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

    摘要翻译： 式（I）化合物，其对映异构体，非对映体或其药学上可接受的盐，其中A独立地选自：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和W如本文所述。 还公开了式（II）的化合物，其对映异构体，非对映异构体或其药学上可接受的盐，其中G，X和Y各自独立地为CH或N，其中在每次出现时，G，X或Y中的至少一个 是N，另外两个G，X或Y是CH; 并且B独立地选自：其中R 1，R 2，R 3，R 4，R 5，R 8，R 9和Z如本文所述。 还公开了含有式（I）和式（II）化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

    Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
    20.
    发明授权
    Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors 有权
    可用作激酶抑制剂的苯并噻唑和氮杂苯并噻唑化合物

    公开(公告)号：US07473784B2

    公开(公告)日：2009-01-06

    申请号：US11494234

    申请日：2006-07-27

    申请人： Chunjian Liu ,  Katerina Leftheris ,  James Lin

    发明人： Chunjian Liu ,  Katerina Leftheris ,  James Lin

    IPC分类号： A61K31/428 ,  C07D417/04

    CPC分类号： C07D513/04 ,  C07D417/04

    摘要： A compound of Formula (I) an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is as described herein. Also disclosed is a compound of Formula (II) an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B, R1, R2, R3, R4, R5, R8, R9 and Z are as described herein. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

    摘要翻译： 式（I）的化合物，其对映体，非对映异构体或其药学上可接受的盐，其中A如本文所述。 还公开了式（II）的化合物，其对映异构体，非对映异构体或其药学上可接受的盐，其中G，X和Y各自独立地为CH或N，其中在每次出现时，G，X或Y中的至少一个 是N，另外两个G，X或Y是CH; 并且B，R 1，R 2，R 3，R 4，R 5，R 8，R 9和Z如本文所述。 还公开了含有式（I）和式（II）化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。