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公开(公告)号：US20080004278A1
公开(公告)日：2008-01-03
申请号：US11832924
申请日：2007-08-02
Applicant: Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
Inventor： Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
IPC: C07D231/10 , A61K31/4155 , A61K31/5377 , C07D403/02 , C07D413/02 , C07D231/56 , A61P29/00
CPC classification number: C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
Abstract translation: 本发明提供了可用于治疗p38激酶相关病症的式（I）的吡唑衍生化合物，其中W，X，R 1，R 2，R 2， R 3，R 4，R 5，R 6和m如本文所定义。 本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。
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公开(公告)号：US07160883B2
公开(公告)日：2007-01-09
申请号：US10420399
申请日：2003-04-22
Applicant: Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski
Inventor： Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski
IPC: C07D487/04 , C07D413/08 , A61K31/53 , A61K31/5377 , A61P19/02 , A61P19/04 , A61P9/10
CPC classification number: C07D487/04
Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
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![Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2006/05/18/US20060106051A1/abs.jpg.150x150.jpg)
3.发明申请Imidazo-fused oxazolo[4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US20060106051A1
公开(公告)日：2006-05-18
申请号：US11272401
申请日：2005-11-10
Applicant: Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
Inventor： Alaric Dyckman , William Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven Spergel , F. Zusi
IPC: A61K31/4745 , C07D498/14
CPC classification number: C07D513/14
Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
Abstract translation: 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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公开(公告)号：US20060247247A1
公开(公告)日：2006-11-02
申请号：US11477010
申请日：2006-06-28
Applicant: Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
Inventor： Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
IPC: A61K31/501 , A61K31/4709 , A61K31/454 , A61K31/4439 , A61K31/4152 , C07D403/02
CPC classification number: C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
Abstract translation: 本发明提供了可用于治疗p38激酶相关病症的式（I）的吡唑衍生化合物，其中W，X，R 1，R 2，R 2， R 3，R 4，R 5，R 6和m如本文所定义。 本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。
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公开(公告)号：US20050004176A1
公开(公告)日：2005-01-06
申请号：US10837778
申请日：2004-05-03
Applicant: Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
Inventor： Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
IPC: A61K20060101 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/535 , A61K31/675 , C07D20060101 , C07D231/04 , C07D231/14 , C07D231/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/12 , C07D413/14 , C07
CPC classification number: C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
Abstract translation: 本发明提供了可用于治疗p38激酶相关病症的式（I）的吡唑衍生化合物，其中G，X，R 1，R 2，R 3，R 4，R 5，R 6和m如本文所定义。 本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。
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Patent Agency Ranking
公开(公告)号：US20100240646A1
公开(公告)日：2010-09-23
申请号：US12793016
申请日：2010-06-03
Applicant: Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski
Inventor： Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski
IPC: A61K31/5377 , C07D487/04 , A61K31/53 , A61P11/06 , A61P3/10 , A61P19/10 , A61P9/10 , A61P19/02 , A61P17/06 , A61P37/06
CPC classification number: C07D487/04
Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R1，R2，R3，R4，R5，R6，X和Z如说明书中所述。
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公开(公告)号：US20090105243A1
公开(公告)日：2009-04-23
申请号：US12259483
申请日：2008-10-28
Applicant: Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski
Inventor： Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen T. Wrobleski
IPC: A61K31/53 , C07D487/04 , A61K31/5377
CPC classification number: C07D487/04
Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R1，R2，R3，R4，R5，R6，X和Z如说明书中所述。
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![Imidazo-fused oxazolo [4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same](/abs-image/US/2008/11/25/US07456194B2/abs.jpg.150x150.jpg)
8.发明授权Imidazo-fused oxazolo [4,5-b]pyridine and imidazo-fused thiazolo[4,5-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same 有权咪唑并恶唑并[4,5-b]吡啶和咪唑并稠合的噻唑并[4,5-b]吡啶三环化合物和包含它们的药物组合物公开(公告)号：US07456194B2
公开(公告)日：2008-11-25
申请号：US11272401
申请日：2005-11-10
Applicant: Alaric Dyckman , William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven H. Spergel , F. Christopher Zusi
Inventor： Alaric Dyckman , William J. Pitts , Makonen Belema , Patrice Gill , James Kempson , Yuping Qiu , Claude Quesnelle , Steven H. Spergel , F. Christopher Zusi
IPC: A61K31/4365 , A61K31/437 , C07D471/14 , C07D471/16
CPC classification number: C07D513/14
Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
Abstract translation: 本发明提供具有式（I）的吡唑并嘌呤类三环化合物，其中R 1，R 2，R 3和R 3，R 如本文所述。 本发明还提供包含这些化合物的药物组合物，以及这些化合物用于治疗炎症和免疫疾病的用途。
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公开(公告)号：US20080108626A1
公开(公告)日：2008-05-08
申请号：US11931309
申请日：2007-10-31
Applicant: Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
Inventor： Alaric Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Robert Moquin , Stephen Wrobleski
IPC: A61K31/501 , C07D231/12 , A61K31/415 , C07D413/12 , A61K31/42 , C07D413/14 , A61K31/4439 , C07D401/04
CPC classification number: C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
Abstract: The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
Abstract translation: 本发明提供了可用于治疗p38激酶相关病症的式（I）的吡唑衍生化合物，其中G，X，R 1，R 2，R 2， R 3，R 4，R 5，R 6和m如本文所定义。 本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。
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公开(公告)号：US20070043053A1
公开(公告)日：2007-02-22
申请号：US11585598
申请日：2006-10-24
Applicant: Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen Wrobleski
Inventor： Alaric Dyckman , John Hynes , Katerina Leftheris , Chunjian Liu , Stephen Wrobleski
IPC: A61K31/53 , C07D487/04
CPC classification number: C07D487/04
Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R 1，R 2，R 2， 3，R 4，R 5，R 6，X和Z如说明书中所述。
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