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公开(公告)号:US07951955B2
公开(公告)日:2011-05-31
申请号:US12113718
申请日:2008-05-01
IPC分类号: C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/16
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的衍生物,包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途,以及可用于制备式I化合物的新型中间体。
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公开(公告)号:US07829705B2
公开(公告)日:2010-11-09
申请号:US11559253
申请日:2006-11-13
IPC分类号: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4523 , A61K31/496 , A61K31/501 , A61P31/12
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的衍生物,包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途,以及可用于制备式I化合物的新型中间体。
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公开(公告)号:US20070149530A1
公开(公告)日:2007-06-28
申请号:US11559242
申请日:2006-11-13
IPC分类号: A61K31/501 , A61K31/496 , A61K31/495 , A61K31/497 , C07D417/14 , C07D413/14 , C07D403/14
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.
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公开(公告)号:US07166604B2
公开(公告)日:2007-01-23
申请号:US10450005
申请日:2001-12-18
IPC分类号: C07D401/14 , C07D403/14 , A61K31/4523 , A61P31/12
CPC分类号: C07D417/14 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , Y02A50/463
摘要: This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals as well as novel intermediates useful in the preparation of the compounds of formula I
摘要翻译: 本发明涉及式I化合物及其药学上可接受的衍生物,包含这些化合物的药物组合物及其在哺乳动物中治疗微小RNA病毒感染的用途以及可用于制备式I化合物的新中间体
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公开(公告)号:US20050043399A1
公开(公告)日:2005-02-24
申请号:US10494241
申请日:2002-11-08
申请人: Derek Demaine , Graham Inglis , Simon MacDonald , Stephen Shanahan , Simon Tucker , Keith Watson , Wen-Yang Wu
发明人: Derek Demaine , Graham Inglis , Simon MacDonald , Stephen Shanahan , Simon Tucker , Keith Watson , Wen-Yang Wu
IPC分类号: A61K9/12 , A61K9/72 , A61K31/13 , A61K31/215 , A61K31/351 , A61K31/7052 , A61K31/7056 , A61K45/00 , A61K45/06 , A61K47/48 , A61M15/00 , A61P3/12 , A61P11/00 , A61P27/16 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P43/00 , C07B53/00 , C07D309/28 , A61K31/35 , C07D45/02
CPC分类号: A61K31/7056 , A61K31/13 , A61K31/351 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , A61K2300/00
摘要: The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译: 本发明涉及通式(I)的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; 并且n为10至18的整数或其药学上可接受的衍生物,其制备方法,含有它们的药物制剂或其在预防或治疗病毒感染中的用途。
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公开(公告)号:US20070191216A1
公开(公告)日:2007-08-16
申请号:US10557831
申请日:2004-05-21
申请人: Sandeep Dhingra , Karla Mabe , Keith Watson
发明人: Sandeep Dhingra , Karla Mabe , Keith Watson
IPC分类号: B01J27/26
CPC分类号: C08G65/2663 , B01J27/26 , B01J35/0013
摘要: Nano-scale DMC catalyst complexes are highly active alkylene oxide polymerization catalysts. Thy show a greatly improved ability to catalyze the formation of EO-capping onto secondary hydroxyl-terminated polyethers. The catalysts can be prepared by precipitation in the dispersed adequous phase of a water-in-oil emulsion.
摘要翻译: 纳米级DMC催化剂络合物是高活性烯化氧聚合催化剂。 这表明极大地提高了催化EO封端在二羟基封端的聚醚上形成的能力。 催化剂可以通过在油包水乳液的分散充分相中沉淀来制备。
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公开(公告)号:US20070099917A1
公开(公告)日:2007-05-03
申请号:US11544166
申请日:2006-10-06
申请人: Edouard Nice , Antony Burgess , Keith Watson
发明人: Edouard Nice , Antony Burgess , Keith Watson
IPC分类号: A61K31/5377 , A61K31/517 , C07D413/02 , C07D403/02 , C07D239/94
CPC分类号: C07D239/94
摘要: The present invention relates to novel tyrosine kinase (TK) inhibitors in the form of prodrugs.
摘要翻译: 本发明涉及前体形式的新型酪氨酸激酶(TK)抑制剂。
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公开(公告)号:US5298480A
公开(公告)日:1994-03-29
申请号:US701166
申请日:1991-05-17
申请人: Keith Watson , Wayne Best
发明人: Keith Watson , Wayne Best
IPC分类号: A01N47/36 , C07D239/38 , C07D239/60 , C07D403/12 , C07D521/00 , A01N43/66
CPC分类号: C07D521/00 , A01N47/36 , C07D239/38 , C07D239/60
摘要: The invention embraces compounds of formula ##STR1## and salts thereof, wherein: X and Y are independently selected from various optionally substituted alkoxy, alkenyloxy, alkynyoxy and phenoxy groups;W is oxygen or sulfur;R.sub.1 is hydrogen or alkyl;E is CH or N;R.sub.2 and R.sub.3 are independently selected from various halo, alkyl, alkoxy and amino substituents.The compounds of the invention show herbicidal properties particularly for the control of broad leaf plants in grass crops such as wheat. In further embodiments the invention provides processes for the preparation of compounds I, intermediates useful in the preparation of compounds of formula I, compositions containing as active ingredient a compound of formula I and herbicidal and plant growth regulating processes utilizing compounds of formula I.
摘要翻译: 本发明包括式(*化学结构*)I及其盐的化合物,其中:X和Y独立地选自各种任选取代的烷氧基,烯氧基,炔氧基和苯氧基; W是氧或硫; R1是氢或烷基; E为CH或N; R2和R3独立地选自各种卤素,烷基,烷氧基和氨基取代基。 本发明的化合物显示特别用于控制诸如小麦的草作物中的阔叶植物的除草性质。 在进一步的实施方案中,本发明提供了制备化合物I的方法,可用于制备式I化合物的中间体,含有式I化合物的活性成分的组合物和利用式I化合物的除草和植物生长调节方法。
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19.
公开(公告)号:US20060026244A1
公开(公告)日:2006-02-02
申请号:US10903435
申请日:2004-07-30
申请人: Keith Watson
发明人: Keith Watson
IPC分类号: G06F15/16
CPC分类号: H04L51/28 , G06Q10/107
摘要: A method, system and graphic user interface for modifying a recipient field label associated with a recipient of an e-mail message are disclosed. A recipient field label modifier function is provided that operates to modify the recipient field label associated with a selected recipient. An object associated with the modifier function is provided on a screen including a list of e-mail recipients. Selection of the object associated with the modifier function causes objects to be displayed for modifying the recipient field label associated with a selected recipient to any available type of recipient field label.
摘要翻译: 公开了一种用于修改与电子邮件消息的接收者相关联的接收者字段标签的方法,系统和图形用户界面。 提供了接收者字段标签修饰符功能,其操作来修改与选择的接收者相关联的接收者字段标签。 在包括电子邮件收件人列表的屏幕上提供与修饰器功能相关联的对象。 与修饰符函数相关联的对象的选择将导致显示对象以将与所选接收者相关联的收件人字段标签修改为任何可用类型的收件人字段标签。
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公开(公告)号:US20060025562A1
公开(公告)日:2006-02-02
申请号:US11110051
申请日:2005-04-20
申请人: Robert Dion , Brian Jazdzewski , Francis Timmers , Keith Watson , Paul Vosejpka
发明人: Robert Dion , Brian Jazdzewski , Francis Timmers , Keith Watson , Paul Vosejpka
IPC分类号: C08G63/87
CPC分类号: C08G63/85 , C08G63/181 , C08G2650/34
摘要: Cyclic oligomers containing ester linkages are polymerized in the presence of a catalyst having at least one oxygen atom bonded to two metal atoms. At least one of the metal atoms is a tin atom, which is preferably tetravalent, i.e., bonded to three other groups in addition to the oxygen atom. The other metal atom may also be another tin atom, which is again preferably tetravalent, or a zinc, aluminum or titanium atom. The catalyst may contain multiple oxygen atoms that are bonded to two such metal atoms as described. These catalysts are active, efficient polymerization catalysts. They are often liquids at polymerization temperatures. The catalysts can be formed in situ in the polymerization process, which provides additional flexibility in the process and increased storage stability of starting materials.
摘要翻译: 含有酯键的环状低聚物在具有键合至两个金属原子的至少一个氧原子的催化剂存在下聚合。 至少一个金属原子是锡原子,其优选是四价的,即除了氧原子之外还与三个其它基团键合。 另一个金属原子也可以是另一个锡原子,其又优选为四价,或者是锌,铝或钛原子。 催化剂可以含有多个氧原子,其与所述的两个这样的金属原子键合。 这些催化剂是活性的,有效的聚合催化剂。 它们在聚合温度下通常是液体。 催化剂可以在聚合过程中原位形成,这在工艺中提供了额外的灵活性并提高了原料的储存稳定性。
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