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    DIMERIC COMPOUNDS AND THEIR USE AS ANTI-VIRAL AGENTS
    1.
    发明申请
    DIMERIC COMPOUNDS AND THEIR USE AS ANTI-VIRAL AGENTS 有权
    二元化合物及其用作反病毒剂

    公开(公告)号：US20070225361A1

    公开(公告)日：2007-09-27

    申请号：US11695268

    申请日：2007-04-02

    申请人： Derek Demaine ,  Haydn Jones ,  Simon MacDonald ,  Andrew Mason ,  Stephen Shanahan

    发明人： Derek Demaine ,  Haydn Jones ,  Simon MacDonald ,  Andrew Mason ,  Stephen Shanahan

    IPC分类号： A61K31/351

    CPC分类号： A61K45/06 ,  A61K31/13 ,  A61K31/351 ,  A61K31/7056 ,  A61K47/54 ,  A61K47/55 ,  C07D309/28 ,  A61K2300/00

    摘要： The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; n and q are either the same or different and selected from 0, 1 or 2; and X is an optionally substituted phenyl, optionally substituted naphthyl or optionally substituted phenyl-Y-optionally substituted phenyl in which Y is selected from a covalent bond, CH2, CH2CH2, O or SO2, or a pharmaceutically acceptable derivative thereof, with the proviso that when X is phenyl or naphthyl, n and q are both 2 and when X is phenyl-Y-phenyl in which Y is a covalent bond, then n and q are not both 0, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.

    摘要翻译： 本发明涉及通式（I）的化合物，其中：R是氨基或胍基; R 2是乙酰基或三氟乙酰基; n和q相同或不同，选自0,1或2; 并且X是任选取代的苯基，任选取代的萘基或任选取代的苯基-Y-任选取代的苯基，其中Y选自共价键，CH 2，CH 2， CH 2，O或SO 2，或其药学上可接受的衍生物，条件是当X是苯基或萘基时，n和q都是2，当X是 苯基-Y-苯基，其中Y是共价键，则n和q都不为0，其制备方法，含有它们的药物制剂或其用于预防或治疗病毒感染。