公开(公告)号：US07807797B2

公开(公告)日：2010-10-05

申请号：US11981771

申请日：2007-10-31

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： C07K16/00 ,  A61K39/395

CPC分类号： C07K16/2818 ,  C07K2317/21 ,  C07K2317/73

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码核酸序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。

公开(公告)号：US07824679B2

公开(公告)日：2010-11-02

申请号：US11981810

申请日：2007-10-31

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： A61K39/395

CPC分类号： C07K16/2818 ,  C07K2317/21 ,  C07K2317/73

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码尼罗肽的序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。

公开(公告)号：US20080233122A1

公开(公告)日：2008-09-25

申请号：US11981810

申请日：2007-10-31

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  C12P21/04 ,  C12N15/11 ,  C12N15/00 ,  A61K31/70 ,  A01K67/027 ,  A01H5/00 ,  A61P43/00

CPC分类号： C07K16/2818 ,  C07K2317/21 ,  C07K2317/73

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码尼罗肽的序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。

公开(公告)号：US20080233116A1

公开(公告)日：2008-09-25

申请号：US11981771

申请日：2007-10-31

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12P21/04 ,  C12N5/06 ,  C12N15/11 ,  C12N15/00 ,  A61K31/70 ,  A01K67/027 ,  A01H5/00 ,  A61P43/00

CPC分类号： C07K16/2818 ,  C07K2317/21 ,  C07K2317/73

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码核酸序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。

公开(公告)号：US20120045442A1

公开(公告)日：2012-02-23

申请号：US11981824

申请日：2007-10-31

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/42

CPC分类号： C07K16/2818 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  G01N33/56972 ,  G01N33/6863

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码尼罗肽的序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。

公开(公告)号：US07132281B2

公开(公告)日：2006-11-07

申请号：US10776649

申请日：2004-02-10

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： C12N5/10 ,  C12P21/08

CPC分类号： C07K16/2818 ,  A61K39/39558 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  G01N33/56972 ,  G01N33/6863

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码尼罗肽的序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。

公开(公告)号：US07049426B2

公开(公告)日：2006-05-23

申请号：US09999321

申请日：2001-11-30

申请人： Larry L. Green ,  Vladimir E. Ivanov ,  C. Geoffrey Davis

发明人： Larry L. Green ,  Vladimir E. Ivanov ,  C. Geoffrey Davis

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/63 ,  A01K67/00

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/241 ,  C07K16/244 ,  C07K16/248 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/52 ,  C12N5/0606 ,  C12N2510/00 ,  C12N2800/30 ,  C12N2830/00

摘要： The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with any virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exons encoding the desired heavy chain isotype, operably linked to switch segments from a constant region of a different heavy chain isotype, i.e., a non-cognate switch region. Said additional constant region segment comprises a switch region and human constant region coding segment, wherein the constant region coding segment is operably linked to a switch region that it is not normally associated with, i.e., a non-cognate switch region. In the transgenes of the invention, the non-cognate switch region may be a switch region from a different species than the constant region coding segment. The switch region and membrane exons of the invention may comprise a human gamma-2 constant region and the secreted constant region exons are from a human gamma-1 or a human gamma-4 constant region.

公开(公告)号：US06833268B1

公开(公告)日：2004-12-21

申请号：US09329582

申请日：1999-06-10

申请人： Larry L. Green ,  Vladimir E. Ivanov ,  C. Geoffrey Davis

发明人： Larry L. Green ,  Vladimir E. Ivanov ,  C. Geoffrey Davis

IPC分类号： C12N1563

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/241 ,  C07K16/244 ,  C07K16/248 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/52 ,  C12N5/0606 ,  C12N2510/00 ,  C12N2800/30 ,  C12N2830/00

摘要： The present invention provides fully human antibodies in a transgenic animal of a desired isotype in response to immunization with any virtually any desired antigen. The human immunoglobulin heavy chain transgene in the foregoing animals comprises a human constant region gene segment comprising exons encoding the desired heavy chain isotype, operably linked to switch segments from a constant region of a different heavy chain isotype, i.e., a non-cognate switch region. Said additional constant region segment comprises a switch region and human constant region coding segment, wherein the constant region coding segment is operably linked to a switch region that it is not normally associated with, i.e., a non-cognate switch region. In the transgenes of the invention, the non-cognate switch region may be a switch region from a different species than the constant region coding segment. The switch region and membrane exons of the invention may comprise a human gamma-2 constant region and the secreted constant region exons are from a human gamma-1 or a human gamma-4 constant region.

摘要翻译： 本发明在任何实际上任何所需抗原的免疫响应中，在所需同种型的转基因动物中提供完全人抗体。 前述动物中的人免疫球蛋白重链转基因包含人恒定区基因片段，其包含编码所需重链同种型的外显子，其可操作地连接于不同重链同种型的恒定区切换片段，即非同源转换区 。 所述附加恒定区段包括开关区域和人类恒定区域编码区段，其中恒定区域编码段可操作地连接到其通常不与非同源开关区域相关联的开关区域。 在本发明的转基因中，非同源开关区可以是来自与恒定区编码区不同的种的开关区。 本发明的切换区和膜外显子可以包含人γ-2恒定区，分泌的恒定区外显子来自人γ-1或人γ-4恒定区。

公开(公告)号：US06682736B1

公开(公告)日：2004-01-27

申请号：US09472087

申请日：1999-12-23

申请人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

发明人： Douglas Charles Hanson ,  Mark Joseph Neveu ,  Eileen Elliott Mueller ,  Jeffrey Herbert Hanke ,  Steven Christopher Gilman ,  C. Geoffrey Davis ,  Jose Ramon Corvalan

IPC分类号： A51K39395

CPC分类号： C07K16/2818 ,  C07K2317/21 ,  C07K2317/73

摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

摘要翻译： 根据本发明，提供了针对人细胞毒性T淋巴细胞抗原4（CTLA-4）的完全人单克隆抗体。 提供了编码尼罗肽的序列和包含重链和轻链免疫球蛋白分子，特别是跨越互补决定区（CDR）的连续重链和轻链序列，特别是来自FR1和/或CDR1至CDR3和/或FR4内的重链和轻链序列。 还提供了具有相似结合特性的抗体和具有与本文公开的抗体相似功能的抗体（或其它拮抗剂）。