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公开(公告)号：US20160122775A1
公开(公告)日：2016-05-05
申请号：US14895059
申请日：2014-06-02
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph AHARONI , Maxim ITKIN
IPC: C12N15/82
CPC classification number: C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: The present invention relates to genetically modified plants by key genes involved in the biosynthesis of steroidal alkaloids. These plants have altered content of steroidal (glyco)alkaloids. Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids are provided.
Abstract translation: 本发明涉及通过涉及甾体生物碱生物合成的关键基因的遗传修饰植物。 这些植物改变了类固醇（glyco）生物碱的含量。 提供了抗营养型甾体生物碱含量降低的茄科作物。
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公开(公告)号：US20250092415A1
公开(公告)日：2025-03-20
申请号：US18910862
申请日：2024-10-09
Applicant: Yeda Research and Development Co. Ltd. , Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Inventor： Asaph AHARONI , Prashant SONAWANE , Pablo D. CARDENAS , Saul BURDMAN
Abstract: Disclosed herein are genetically modified plants having altered biological activity of 3-β-hydroxysteroid dehydrogenase/isomerase (GAME25), or 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plants have an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Further disclosed herein are genetically modified plants having altered expression of a gene encoding a 3-β-hydroxysteroid dehydrogenase/isomerase (GAME25), or a 2-oxoglutarate-dependent dioxygenase (GAME31), or a combination thereof, wherein the genetically modified plant has an altered content of at least one cholesterol derived compound selected from the group including a steroidal alkaloid or a glycosylated derivative thereof and an unsaturated or saturated steroidal saponin or a glycoside derivative thereof. Methods of producing these genetically modified plants are also disclosed.
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公开(公告)号：US20240315192A1
公开(公告)日：2024-09-26
申请号：US18735258
申请日：2024-06-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventor： Asaph AHARONI , Prashant SONAWANE , Maxim ITKIN , Adam JOZWIAK
CPC classification number: A01H6/82 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.
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公开(公告)号：US20210007363A1
公开(公告)日：2021-01-14
申请号：US17040227
申请日：2019-03-21
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD
Inventor： Asaph AHARONI , Elisa KORENBLUM
IPC: A01N63/38 , C07D305/14 , C07J17/00 , A01N63/20 , A01G29/00
Abstract: Provided is a plant exudate, methods for obtaining a plant exudate by inducing the plant to secrete an exudate and systems for the collection of a plant exudate which include: one or more plant container including at least two discrete compartments each configured to accommodate a split root of a plant, the compartments being a root stimulating compartment including one or more input being in fluid communication with at least a source of a plant root stimulant, and a root exudate harvesting compartment, and a root exudate collection compartment in fluid communication with the root exudate harvesting compartment.
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