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    METHOD AND APPARATUS FOR PACING AND INTERMITTENT ISCHEMIA
    11.
    发明申请
    METHOD AND APPARATUS FOR PACING AND INTERMITTENT ISCHEMIA 审中-公开
    方法和装置用于切割和间歇性间断

    公开(公告)号：US20090318749A1

    公开(公告)日：2009-12-24

    申请号：US12484822

    申请日：2009-06-15

    申请人： Craig Stolen ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Eric A. Mokelke

    发明人： Craig Stolen ,  Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Eric A. Mokelke

    IPC分类号： A61M1/12 ,  A61N1/365

    CPC分类号： A61N1/056 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/026 ,  A61F2/95 ,  A61N1/3625 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36564 ,  A61N1/36571

    摘要： A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.

    摘要翻译： 系统提供多种增强疗法以限制血运重建后的心肌损伤。 该系统包括导管，其包括用于递送心脏保护起搏治疗（CPPT）和间歇性缺血治疗的特征。 在一个实施方案中，提供了将心脏保护治疗递送至心脏的方法。 提供一个或多个导管，其具有球囊，至少一个起搏电极和至少一个血流动力学传感器。 使用一个或多个导管同时输送心脏保护起搏治疗（CPPT）和间歇性缺血治疗。 起搏和缺血适应于保护心脏免于缺血和再灌注损伤。 CPPT的传送和间歇性缺血通过监视由至少一个血流动力学传感器感测到的信号的闭环系统来控制。

    Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing
    12.
    发明授权
    Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing 有权
    安全高效地递送心脏应激增加起搏的方法和装置

    公开(公告)号：US08958873B2

    公开(公告)日：2015-02-17

    申请号：US12770351

    申请日：2010-04-29

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Craig Stolen ,  Robert Shipley

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Craig Stolen ,  Robert Shipley

    IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/37

    CPC分类号： A61N1/3627 ,  A61N1/37

    摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.

    摘要翻译： 心脏起搏系统通过递送心脏应力增加起搏来控制心脏疾病例如心力衰竭的进展，以根据为患者编程的递送计划创建或增加心脏中的区域应力。 与患者病情，活动和其他治疗相关的各种事件可能使心脏应激增加起搏风险或无效。 该系统在每个心脏应激增强起搏会话之前和期间检测这些事件，并根据每个事件的检测来修改递送计划，以确保患者的安全性和治疗效率。

    Systems, devices and methods for modulating autonomic tone
    15.
    发明授权
    Systems, devices and methods for modulating autonomic tone 有权
    用于调节自主神经色调的系统，装置和方法

    公开(公告)号：US08626288B2

    公开(公告)日：2014-01-07

    申请号：US12397464

    申请日：2009-03-04

    申请人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Bruce H. KenKnight ,  Douglas R. Daum

    发明人： Allan C. Shuros ,  Shantha Arcot-Krishnamurthy ,  Bruce H. KenKnight ,  Douglas R. Daum

    IPC分类号： A61N1/368

    CPC分类号： A61N1/362 ,  A61N1/36114 ,  A61N1/3627

    摘要： Various embodiments intermittently deliver a sympathetic stimulus, including deliver a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further delivers neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.

    摘要翻译： 各种实施方案间歇地递送交感刺激，包括递送适于在应力诱导起搏期间增加交感神经张力的应力诱发起搏脉冲序列。 应激诱导起搏导致应激诱导起搏顺序后的副交感神经反射。 该实施方案进一步递送神经刺激以相对于应力诱导起搏脉冲的序列以协调的方式引发副交感神经反应或交感神经反应。 神经刺激被定时以在应力诱发起搏脉冲序列之后引起副交感神经反应，并且与应激诱导起搏序列的至少一部分副交感神经反射并发，以增强副交感神经反射的副交感作用，或 在应激诱导脉冲序列期间引起交感神经反应以提供更大的交感神经刺激，导致响应于大的交感神经刺激的增强的副交感神经反射。

    METHOD AND APPARATUS FOR SAFE AND EFFICIENT DELIVERY OF CARDIAC STRESS AUGMENTATION PACING
    19.
    发明申请
    METHOD AND APPARATUS FOR SAFE AND EFFICIENT DELIVERY OF CARDIAC STRESS AUGMENTATION PACING 有权
    安全有效地提供CARDIAC应力补充剂的方法和装置

    公开(公告)号：US20100305648A1

    公开(公告)日：2010-12-02

    申请号：US12770351

    申请日：2010-04-29

    申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Craig Stolen ,  Robert Shipley

    发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Craig Stolen ,  Robert Shipley

    IPC分类号： A61N1/365 ,  A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/37

    摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.

    摘要翻译： 心脏起搏系统通过递送心脏应力增加起搏来控制心脏疾病例如心力衰竭的进展，以根据为患者编程的递送计划创建或增加心脏中的区域应力。 与患者病情，活动和其他治疗相关的各种事件可能使心脏应激增加起搏风险或无效。 该系统在每个心脏应激增强起搏会话之前和期间检测这些事件，并根据每个事件的检测来修改递送计划，以确保患者的安全性和治疗效率。

    APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION
    20.
    发明申请
    APPARATUS AND METHODS FOR TREATMENT OF ATHEROSCLEROSIS AND INFARCTION 审中-公开
    用于治疗角膜移植和感染的装置和方法

    公开(公告)号：US20100016916A1

    公开(公告)日：2010-01-21

    申请号：US12504593

    申请日：2009-07-16

    申请人： Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Allan C. Shuros ,  Scott A. Meyer ,  Robert Shipley ,  Jason J. Hamann

    发明人： Shantha Arcot-Krishnamurthy ,  Joseph M. Pastore ,  Allan C. Shuros ,  Scott A. Meyer ,  Robert Shipley ,  Jason J. Hamann

    IPC分类号： A61N1/368

    CPC分类号： A61N1/36564 ,  A61N1/36528 ,  A61N1/36571 ,  A61N1/368

    摘要： A pacing system delivers cardiac protective pacing therapy (CPPT) to protect the heart from injuries and/or to treat existing injuries. The pacing system receives a set of inputs and delivers optimized cardiac protection pacing tailored for different purposes. The system delivers electrical stimulation to modulate myocardial strain for anti-atherosclerosis therapy and/or to provide therapy for myocardial infarction (MI). In one embodiment, a medical device for treating atherosclerosis is provided. The medical device includes a sensing circuit to receive sensed signals to identify areas of coronary artery disease (CAD) or areas at risk for CAD using the sensed signals. The device also includes a pacemaker circuit adapted to deliver an electrical signal through at least one electrode to a myocardial target adjacent to the identified areas. According to various embodiments, a controller communicates with the sensing circuit and controls the pacemaker circuit to provide intermittent electrical stimulation to the myocardial target to induce periods of stretch on the vessel due to induce myocardial strain changes. The stimulation is targeted to attenuate or prevent atherosclerosis associated with the CAD, according to various embodiments.

    摘要翻译： 起搏系统提供心脏保护起搏治疗（CPPT），以保护心脏免受伤害和/或治疗现有的伤害。 起搏系统接收一组输入，并为不同目的提供优化的心脏保护起搏。 该系统提供电刺激以调节用于抗动脉粥样硬化治疗的心肌应变和/或提供心肌梗塞（MI）治疗。 在一个实施方案中，提供了用于治疗动脉粥样硬化的医疗装置。 医疗设备包括感测电路，用于接收感测到的信号，以使用感测到的信号来识别冠状动脉疾病（CAD）或CAD风险区域。 该装置还包括起搏器电路，其适于将电信号通过至少一个电极传递到与所识别的区域相邻的心肌靶。 根据各种实施例，控制器与感测电路通信并控制起搏器电路，以向心肌靶标提供间歇性电刺激，以诱导由于诱发心肌应变变化而在血管上延伸的时间段。 根据各种实施方案，刺激旨在减弱或预防与CAD相关的动脉粥样硬化。