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89 条记录 (耗时 0.058 秒)

    6-11 Bridged Oxime Erythromycin Derivatives
    11.
    发明申请
    6-11 Bridged Oxime Erythromycin Derivatives 审中-公开
    6-11桥接肟红霉素衍生物

    公开(公告)号：US20100041618A1

    公开(公告)日：2010-02-18

    申请号：US12543155

    申请日：2009-08-18

    申请人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    发明人： Guoqiang Wang ,  Ly Tam Phan ,  Yat Sun Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    IPC分类号： A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6-11 Bridged oxime erythromycin derivatives
    13.
    发明申请
    6-11 Bridged oxime erythromycin derivatives 审中-公开
    6-11桥接肟红霉素衍生物

    公开(公告)号：US20060252710A1

    公开(公告)日：2006-11-09

    申请号：US11122251

    申请日：2005-05-04

    申请人： Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    发明人： Guoqiang Wang ,  Ly Phan ,  Yat Or ,  Yao-Ling Qiu ,  Deqiang Niu ,  Yulin Peng ,  Marina Busuyek ,  Yanchun Wang ,  Suanne Nakajima

    IPC分类号： C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    Bicyclic 9a-azalide derivatives
    14.
    发明授权
    Bicyclic 9a-azalide derivatives 失效
    双环9a-azalide衍生物

    公开(公告)号：US07402568B2

    公开(公告)日：2008-07-22

    申请号：US11236043

    申请日：2005-09-27

    申请人： Yat Sun Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    发明人： Yat Sun Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9N-substituted 6-11 bicyclic erythromycin derivatives
    15.
    发明授权
    9N-substituted 6-11 bicyclic erythromycin derivatives 失效
    9N-取代的6-11双环红霉素衍生物

    公开(公告)号：US07265094B2

    公开(公告)日：2007-09-04

    申请号：US11031465

    申请日：2005-01-07

    申请人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Tam Phan ,  Yat Sun Or

    发明人： Yao-Ling Qiu ,  Deqiang Niu ,  Zhe Wang ,  Ly Tam Phan ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋物，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6-11 bicyclic ketolide derivatives
    16.
    发明授权
    6-11 bicyclic ketolide derivatives 有权
    6-11双环酮内酯衍生物

    公开(公告)号：US07189704B2

    公开(公告)日：2007-03-13

    申请号：US11154260

    申请日：2005-06-16

    申请人： Deqiang Niu ,  Guoqiang Wang ,  Yat Sun Or ,  Ly Tam Phan

    发明人： Deqiang Niu ,  Guoqiang Wang ,  Yat Sun Or ,  Ly Tam Phan

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

    摘要： The present invention discloses, inter alia, a compound of the following formula, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the aforementioned compounds. The invention further includes processes by which to make the compounds of the present invention.

    摘要翻译： 本发明尤其公开了下式的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含上述化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    11-O-substituted macrolides and their descladinose derivatives
    17.
    发明授权
    11-O-substituted macrolides and their descladinose derivatives 失效
    11-O-取代的大环内酯类及其衍生物

    公开(公告)号：US06673774B2

    公开(公告)日：2004-01-06

    申请号：US10011322

    申请日：2001-12-03

    申请人： Ly Tam Phan Phan ,  Deqiang Niu ,  Yat Sun Or

    发明人： Ly Tam Phan Phan ,  Deqiang Niu ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described 11-O-substituted macrolides and their descladinose derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了11-O-取代的大环内酯及其下拉曲肽衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法来治疗细菌感染的方法。

    11-O-substituted ketolide derivatives
    18.
    发明授权
    11-O-substituted ketolide derivatives 失效
    11-O-取代的酮内酯衍生物

    公开(公告)号：US06670331B2

    公开(公告)日：2003-12-30

    申请号：US10011642

    申请日：2001-12-04

    申请人： Ly Tam Phan Phan ,  Deqiang Niu ,  Yat Sun Or

    发明人： Ly Tam Phan Phan ,  Deqiang Niu ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described novel 11-O-substituted ketolide derivatives of clarithromycin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了克拉霉素类似物的新的11-O-取代的酮内酯衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法来治疗细菌感染的方法。

    6,11-4-carbon bridged ketolides
    19.
    发明授权
    6,11-4-carbon bridged ketolides 有权
    6,11-4-碳桥接的酮内酯

    公开(公告)号：US06841664B2

    公开(公告)日：2005-01-11

    申请号：US10205018

    申请日：2002-07-25

    申请人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    发明人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    IPC分类号： A61P31/04 ,  C07H17/08 ,  A61K31/70

    CPC分类号： C07H17/08

    摘要： Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

    摘要翻译： 描述了包含治疗有效量的本发明化合物与药学上可接受的载体的新颖的6,11-4-碳桥连酮内酯，药学上可接受的组合物。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。

    6,11-4-carbon bridged erythromycin derivatives
    20.
    发明授权
    6,11-4-carbon bridged erythromycin derivatives 有权
    6,11-4碳桥联红霉素衍生物

    公开(公告)号：US06753318B1

    公开(公告)日：2004-06-22

    申请号：US10205357

    申请日：2002-07-25

    申请人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    发明人： Yat Sun Or ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Tam Phan

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： Novel 6,11-4-carbon bridged erythromycin derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are methods for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.

    摘要翻译： 描述了新颖的6,11-4-碳桥连红霉素衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。